Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin E + Manganese + Methyl sulfonyl methane Pharmacology

Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin E + Manganese + Methyl sulfonyl methane

About Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin E + Manganese + Methyl sulfonyl methane
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Mechanism of Action of Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin E + Manganese + Methyl sulfonyl methane
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Pharmacokinets of Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin E + Manganese + Methyl sulfonyl methane
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Onset of Action for Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin E + Manganese + Methyl sulfonyl methane
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Duration of Action for Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin E + Manganese + Methyl sulfonyl methane
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Half Life of Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin E + Manganese + Methyl sulfonyl methane
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Side Effects of Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin E + Manganese + Methyl sulfonyl methane
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Contra-indications of Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin E + Manganese + Methyl sulfonyl methane
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Special Precautions while taking Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin E + Manganese + Methyl sulfonyl methane
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Pregnancy Related Information
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Old Age Related Information
N/A
Breast Feeding Related Information
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Children Related Information
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Indications for Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin E + Manganese + Methyl sulfonyl methane
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Interactions for Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin E + Manganese + Methyl sulfonyl methane
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Typical Dosage for Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin E + Manganese + Methyl sulfonyl methane
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Schedule of Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin E + Manganese + Methyl sulfonyl methane
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Storage Requirements for Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin E + Manganese + Methyl sulfonyl methane
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Effects of Missed Dosage of Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin E + Manganese + Methyl sulfonyl methane
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Effects of Overdose of Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin E + Manganese + Methyl sulfonyl methane
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Glucosamine

About Glucosamine
Amino sugar,Monosaccharide derivative, Anti-inflammatory,Antiarthritic.
Mechanism of Action of Glucosamine
It stimulates cartilage cells to produce glucosaminoglycans and proteoglycans which are the building blocks of cartilage. This stops the progression of OA (osteoarthritis) and possibly reverses the process. It also has anti-inflammatory properties by its inhibition of proteolytic enzymes.
Pharmacokinets of Glucosamine
Absorption- Well absorbed after oral administration
Distribution- Widely distributed into joint tissues
Excretion - Excreted through urine
Onset of Action for Glucosamine
N/A
Duration of Action for Glucosamine
N/A
Half Life of Glucosamine
N/A
Side Effects of Glucosamine
1. Epigastric pain
2. Tenderness
3. Heartburn
4. Diarrhoea
5. Nausea
6. Drowsiness
7. Headache
8. Insomnia
9. Vomiting
10. Constipation
11. Anorexia
12. Erythema
13. Pruritis
Contra-indications of Glucosamine
Contraindicated in patients with hypersensitivity to the drug
Special Precautions while taking Glucosamine
1.Blood sugars carefully monitored because Glucosamine may increase insulin resistance
2.In normal and diabetic patients
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Glucosamine
1. Osteo arthritis.
2. Rheumatoid arthritis
Interactions for Glucosamine
N/A
Typical Dosage for Glucosamine
Oral-
Adult:1200mg /day
Schedule of Glucosamine
N/A
Storage Requirements for Glucosamine
Store in cool (<30 degree C) and dark place
Effects of Missed Dosage of Glucosamine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Glucosamine
Give symptomatic and supportive treatment

Chondroitin Sulphate

About Chondroitin Sulphate
A sulfated glycosaminoglycan (mucopolysaccharides, Dietary supplement , anti-rheumatic and anti-inflammatory.
Mechanism of Action of Chondroitin Sulphate
Chondroitin sulfate is part of a large protein molecule (proteoglycan) that gives cartilage elasticity.
It stimulates cartilage cells to produce glucosaminoglycans and proteoglycans which are the building blocks of cartilage. This stops the progression of OA (osteoarthritis) and possibly reverses the process. It also has anti-inflammatory properties by its inhibition of proteolytic enzymes.
Pharmacokinets of Chondroitin Sulphate
Absorption- Well absorbed after oral administration
Distribution- Widely distributed into joint tissues
Excretion - Excreted through urine
Onset of Action for Chondroitin Sulphate
N/A
Duration of Action for Chondroitin Sulphate
N/A
Half Life of Chondroitin Sulphate
N/A
Side Effects of Chondroitin Sulphate
1. Epigastric pain
2. Tenderness
3. Heartburn
4. Diarrhoea
5. Nausea
6. Drowsiness
7. Headache
8. Insomnia
9. Vomiting
10. Constipation
11. Anorexia
12. Erythema
13. Pruritis
Contra-indications of Chondroitin Sulphate
Contraindicated in patients with hypersensitivity to the drug
Special Precautions while taking Chondroitin Sulphate
1.Blood sugars carefully monitored because Glucosamine may increase insulin resistance
2.In normal and diabetic patients
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Chondroitin Sulphate
N/A
Interactions for Chondroitin Sulphate
N/A
Typical Dosage for Chondroitin Sulphate
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Schedule of Chondroitin Sulphate
N/A
Storage Requirements for Chondroitin Sulphate
Store in cool (<30 degree C) and dark place
Effects of Missed Dosage of Chondroitin Sulphate
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Chondroitin Sulphate
Give supportive measures and symptomatic treatment.

Vitamin C

About Vitamin C
Water soluble vitamin, antioxidant.
Mechanism of Action of Vitamin C
Vitamin C exerts it`s action by influencing the biologic oxidations and reductions used in cellular respirations. It directly stimulates collagen synthesis and maintains intracellular connective tissue. It involves in various metabolic reactions such as 1).Hydroxylation of praline and lysine residues of protocollagen which is essential for formation and stabilization of collagen triple helix, 2).hydroxylation of carnitine, 3).Conversion of folic acid to folinic acid, 4).biosynthesis of adrenal steroids, catecholamines, oxytocin, and ADH, 5).Metabolism of cyclic nucleotides and prostaglandins. Vitamin C is important in resistance to infections.
Pharmacokinets of Vitamin C
Absorption: Well absorbed orally.
Distribution: Widely distributed both extracellularly and intracellularly, It crosses the placenta and also distributed in to the breast milk.
Metabolism: Metabolized in the liver; partly oxidized in to active dehydroascorbic acid and inactive metabolites.
Excretion: Inactive metabolites and extra drug is excreted through urine.
Onset of Action for Vitamin C
N/A
Duration of Action for Vitamin C
N/A
Half Life of Vitamin C
N/A
Side Effects of Vitamin C
1. Discomfort at injection site
2. Acid urine
3. Renal calculi
4. Oxaluria
Contra-indications of Vitamin C
No known contraindications
Special Precautions while taking Vitamin C
1. Renal impairment
2. Ingestion of large doses during pregnancy has resulted in scurvy in neonates
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
May be used
Indications for Vitamin C
1. Scurvy
2. Prophylaxis and treatment of vitamin C deficiency
3. As an antioxidant to maintain natural colour and flavour of food items
4. For acidification of urine
5. Capillary fragility
6. Dental caries

Interactions for Vitamin C
Oral contraceptives and estrogens: Vitamin C increases serum levels of oestrogen resulting in adverse reactions .
Warfarin: The anticoagulant effects of warfarin is reduced.
Lab Tests: Large doses (>500 mg) of vitamin C may cause false negative urine glucose determinations. May result in false negative amine dependent stool occult blood tests.
Typical Dosage for Vitamin C
Oral:
Adults: 50 to 1000mg/day depending up on the requirement.
Pregnancy and lactation: 100 to 150mg/day
Children: 30 to 100mg/day.
Scurvy:
Oral:
Adults: 1000mg twice daily to thrice daily.
Children: 300mg to 1000mg daily.
Sub clinical scurvy:
Oral, S.C., I.M., or I.V.: 100 to 250mg once daily or twice daily depending up on the severity of the condition. Then give a maintenance dosage of 50mg/day.
Children: 100 to 300mg depending up on the severity. Then give a maintenance dose of 35mg/day.

Schedule of Vitamin C
C1 (Oral)
C (Parenteral)
Storage Requirements for Vitamin C
Store in a cool dry area in a well closed container. Protects from moisture, light and direct heat.
Effects of Missed Dosage of Vitamin C
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Vitamin C
Discontinue the therapy and provide symptomatic and supportive measures.

Vitamin E

About Vitamin E
N/A
Mechanism of Action of Vitamin E
Vitamin E acts as an antioxidant and protecting unsaturated lipids in the cell membrane, coenzyme Q, vitamin A, vitamin C etc. from free radical oxidation damage and generation of toxic peroxidation products. It also decreases platelet aggregation.
Pharmacokinets of Vitamin E
Absorption: Absorbed through lymph with the help of bile. Only 20 to 60% of vitamin from dietary sources is absorbed. As dose increases the fraction absorbed decreases.
Distribution: Widely distributed in a protein bound form and stored in adipose tissue.
Metabolism: Metabolized in liver by glucuronide conjugation.
Excretion: Excreted mainly through bile and also excreted through urine.
Onset of Action for Vitamin E
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Duration of Action for Vitamin E
N/A
Half Life of Vitamin E
N/A
Side Effects of Vitamin E
1. Fatigue
2. Weakness
3. Headache
4. Nausea
5. Diarrhoea
6. Blurred vision
7. Flatulence


Contra-indications of Vitamin E
1. Hypersensitivity to the drug
2. Should not administer intravenously
Special Precautions while taking Vitamin E
1. Hepatic impairment
2. Gall bladder disease
3. Along with estrogens
Pregnancy Related Information
May be used
Old Age Related Information
N/A
Breast Feeding Related Information
May be used
Children Related Information
N/A
Indications for Vitamin E
1. Vitamin E deficiency
2. Intermittent claudication
3. Nocturnal muscle cramps
4. Coronary artery disease
5. Fibrocystic breast disease
6. Cystic fibrosis
7. In premature infants exposed to high concentration of oxygen
8. As antioxidant


Interactions for Vitamin E
Oral anticoagulants : Hypoprothrombinemic effect may be increased with possibility of bleeding.

Typical Dosage for Vitamin E
Oral:
Vitamin E deficiency:
Adults: 40 to 50mg/day or 60 to 75i.u. daily based on the severity of deficiency.
Children: 1 unit/kg/day.
Premature neonates: 5units daily.
Full term neonates: 5 units per liter of formula.
Intermittent claudication: 400mg/day for 12 to 18 weeks.
Nocturnal muscle cramps: 400mg/day for 8 to 12 weeks.
Coronary artery disease: 100 to 200mg/day for at least 2 years.
Fibrocystic breast disease: 600mg/day for at least 2years.
Cystic fibrosis: 100 to 200mg/day.
Children above 1 year: 100mg/day.
Children below 1year: 50mg/day.



Schedule of Vitamin E
C1
Storage Requirements for Vitamin E
Store in a well closed container in a cool dry place. Protect from light.
Effects of Missed Dosage of Vitamin E
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Vitamin E
Provide supportive measures and symptomatic treatment.

Manganese

About Manganese
Magnesium is essential for enzyme activity, calcium and potassium uptake, nerve transmission, bone formation and metabolism of carbohydrates and minerals. It is magnesium, not calcium, which helps form hard tooth enamel, resistant to decay. Like calcium and chloride, magnesium also plays a role in regulating the acid-alkaline balance in the body. High magnesium levels in drinking water have been linked to resistance to heart disease. Although it is found in many foods, including dairy products, nuts, vegetables, fish, meat and seafood, deficiencies are common in America due to soil depletion, poor absorption and lack of minerals in drinking water. A diet high in carbohydrates, oxalic acid in foods like raw spinach and phytic acid found in whole grains can cause deficiencies. An excellent source of usable magnesium is beef, chicken or fish broth. High amounts of zinc and vitamin D increase magnesium requirements. Magnesium deficiency can result in coronary heart disease, chronic weight loss, obesity, fatigue, epilepsy and impaired brain function. Chocolate cravings are a sign of magnesium deficiency.
Mechanism of Action of Manganese
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Pharmacokinets of Manganese
N/A
Onset of Action for Manganese
N/A
Duration of Action for Manganese
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Half Life of Manganese
N/A
Side Effects of Manganese
N/A
Contra-indications of Manganese
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Special Precautions while taking Manganese
N/A
Pregnancy Related Information
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Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Manganese
N/A
Interactions for Manganese
N/A
Typical Dosage for Manganese
N/A
Schedule of Manganese
N/A
Storage Requirements for Manganese
N/A
Effects of Missed Dosage of Manganese
N/A
Effects of Overdose of Manganese
N/A

Methyl sulfonyl methane

About Methyl sulfonyl methane
N/A
Mechanism of Action of Methyl sulfonyl methane
MSM has been proven to have anti-inflammatory and antioxidant mechanisms in an in vitro study6 in which human neutrophils were artificially stimulated to produce oxidative compounds, including hydrogen peroxide, superoxide, and hypochlorous acid. After cell lines were treated with either DMSO or DMSO2, these free radical by-products were decreased.
Pharmacokinets of Methyl sulfonyl methane
N/A
Onset of Action for Methyl sulfonyl methane
N/A
Duration of Action for Methyl sulfonyl methane
N/A
Half Life of Methyl sulfonyl methane
N/A
Side Effects of Methyl sulfonyl methane
1.Nausea
2.Diarrhea
3.Bloating
4.Fatigue
5.Headache
6.Insomnia
7.Itching or worsening of allergy symptoms.
Contra-indications of Methyl sulfonyl methane
N/A
Special Precautions while taking Methyl sulfonyl methane
N/A
Pregnancy Related Information
Not recommended
Old Age Related Information
N/A
Breast Feeding Related Information
Not recommended
Children Related Information
N/A
Indications for Methyl sulfonyl methane
1.To reduce pain and swelling of the joints caused by osteoarthritis.
2.Interstitial cystitis
Interactions for Methyl sulfonyl methane
N/A
Typical Dosage for Methyl sulfonyl methane
Oral: For osteoarthritis: 500 mg three times daily up to 3 grams twice daily.
Schedule of Methyl sulfonyl methane
N/A
Storage Requirements for Methyl sulfonyl methane
N/A
Effects of Missed Dosage of Methyl sulfonyl methane
If a dose is missed, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Effects of Overdose of Methyl sulfonyl methane
If over dosage is suspected,contact immediate medical attention.

Home Delivery for Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin E + Manganese + Methyl sulfonyl methane in Your City

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Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin E + Manganese + Methyl sulfonyl methane is a generic medicine name and there are several brands available for it. Some of the brands for glucosamine + chondroitin sulphate + vitamin c + vitamin e + manganese + methyl sulfonyl methane might be better known than glucosamine + chondroitin sulphate + vitamin c + vitamin e + manganese + methyl sulfonyl methane itself. If the pharmacy that's willing to deliver medicines to your home doesn't have glucosamine + chondroitin sulphate + vitamin c + vitamin e + manganese + methyl sulfonyl methane in stock, you can ask for one of the branded alternatives for glucosamine + chondroitin sulphate + vitamin c + vitamin e + manganese + methyl sulfonyl methane.