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- Pharmacology For Diclofenac Sodium + Serratiopeptidase
Diclofenac Sodium + Serratiopeptidase Pharmacology
Diclofenac Sodium + Serratiopeptidase
About Diclofenac Sodium + SerratiopeptidaseN/AMechanism of Action of Diclofenac Sodium + SerratiopeptidaseN/APharmacokinets of Diclofenac Sodium + SerratiopeptidaseN/AOnset of Action for Diclofenac Sodium + SerratiopeptidaseN/ADuration of Action for Diclofenac Sodium + SerratiopeptidaseN/AHalf Life of Diclofenac Sodium + SerratiopeptidaseN/ASide Effects of Diclofenac Sodium + SerratiopeptidaseN/AContra-indications of Diclofenac Sodium + SerratiopeptidaseN/ASpecial Precautions while taking Diclofenac Sodium + SerratiopeptidaseN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Diclofenac Sodium + SerratiopeptidaseN/AInteractions for Diclofenac Sodium + SerratiopeptidaseN/ATypical Dosage for Diclofenac Sodium + SerratiopeptidaseN/ASchedule of Diclofenac Sodium + SerratiopeptidaseN/AStorage Requirements for Diclofenac Sodium + SerratiopeptidaseN/AEffects of Missed Dosage of Diclofenac Sodium + SerratiopeptidaseN/AEffects of Overdose of Diclofenac Sodium + SerratiopeptidaseN/ADiclofenac Sodium
About Diclofenac SodiumN/AMechanism of Action of Diclofenac SodiumDiclofenac possess analgesic, anti-inflammatory and antipyretic action. It inhibits the enzyme cyclo-oxygenase and there by inhibits the synthesis of Prostaglandins (PGs). It is more potent against cyclo-oxygenase-2 enzyme as compared to other NSAIDs like Indomethacin, Naproxen etc. It reduces intracellular concentrations of free arachidonic acid in leukocyte by altering its release or uptake. .Pharmacokinets of Diclofenac SodiumAbsorption: Diclofenac sodium is rapidly absorbed after oral administration. It undergoes first pass metabolism and its bioavailability is 50 % only. Distribution: It is distributed in highly protein bound form. Metabolism: Diclofenac sodium is metabolised in the liver. Excretion: Drug and metabolites are primarily excreted in urine and some amount in the bile.Onset of Action for Diclofenac Sodium1- 4.5 hoursDuration of Action for Diclofenac SodiumHoursHalf Life of Diclofenac Sodium2 hoursSide Effects of Diclofenac Sodium1.Nausea
2.Vomiting
3.Anorexia
4.Diarrhoea
5.Gastrointestinal bleeding
6.Abdominal distress
7.Constipation
8.Flatulence
9.Ulceration of the stomach or intestine
10.Dyspepsia
11.Headache
12.Dizziness
13. Rash
Contra-indications of Diclofenac Sodium1.Hypersensitivity to Indomethacin and other Non steroidal anti inflammatory drugs(NSAID)
2.Peptic ulcer
3.Asthma
Special Precautions while taking Diclofenac Sodium1.Hepatic impairment
2.Renal impairment
3.Hypertension
4.Blood clotting disorders
5.Gastrointestinal diseases
6.Proctitis
7.Asthma
8.Cautioned against driving, operating or activities requiring concentration
9.Avoid alcohol
10.Heart failure
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
CHILDREN below 14: contraindicatedIndications for Diclofenac Sodium1.Ankylosing spondylitis
2.Acute gout
3.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints
4.Osteoarthritis
5.For the relief of pain and inflammation in dental minor surgery and orthopedic
6.Dysmenorrhoea
7.Juvenile chronic arthritis
8.Migraine
Interactions for Diclofenac SodiumLithium & Digoxin : Blood levels of lithium and digoxin increased leading to enhanced efficacy and posible toxicity.
Diuretics : Inhibits diuretics but efficacy of potassium sparing diuretics enhanced.
Methotrexate : Toxicity enhanced.
Salicylates : Efficacy of salicylates reduced.
Cyclosporine : Increases nephrotoxicity of both agents.
Hydantoins : Increases serum levels resulting in toxicity.
Typical Dosage for Diclofenac SodiumAdult: 100 - 150 mg / day in 2 - 3 divided doses.
For the relief of pain, Migraine, Dysmenorrhoea: 150 mg / day in 3 divided doses.
Osteoarthritis: 50 mg 2 - 3 times daily
Rheumatoid arthritis: 150 - 200 mg / day in 3 - 4 divided doses.
Ankylosing spondylitis: 25 mg 4 times daily give an extra dose of 25 mg at bed time if necessary.
Children Juvenile rheumatoid arthritis: 0.5 - 2 mg / kg body weight / day in divided doses.
Maximum dose: 3 mg / kg body weight / day in divided doses
Schedule of Diclofenac SodiumHStorage Requirements for Diclofenac SodiumStore Diclofenac sodium at room temperature in a tightly closed light resistant container.Effects of Missed Dosage of Diclofenac SodiumTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Diclofenac SodiumGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.Serratiopeptidase
About SerratiopeptidaseA proteolytic enzyme, A powerful anti-inflammatory, anti-edemic.Mechanism of Action of SerratiopeptidaseThis anti-inflammatory proteolytic enzyme bind to the alpha-2-macroglobulin in the blood, which helps to mask its antigenicity.Then it is slowly transferred to the site of inflammation. Serratiopeptidase hydrolyze bradykinin, histamine, serotoxin responsible for oedema.It reduces swelling improves microcirculation and expectoration of sputum. Due to this action Serratiopeptidase has anti-inflammatory, antioedemic and fibrinolytic activity and act rapidly on localized inflammation.Pharmacokinets of SerratiopeptidaseOrally absorbed. In the case of enteric coated tablet absorption take place in the intestine. After absorption it is directly enter in to the bloodstream. It is excreted via urine and bile.Onset of Action for SerratiopeptidaseN/ADuration of Action for Serratiopeptidase8 to 10 hrsHalf Life of SerratiopeptidaseN/ASide Effects of Serratiopeptidase1. Hypersensitivity
2. Anorexia
3. Gastric discomfort
4. Nausea
5. Vomiting
6. Epistaxis
7. Diarrhoea
8. Skin rash
Contra-indications of Serratiopeptidase1. Hypersensitivity to this drug
2. Blood coagulation disorder
Special Precautions while taking Serratiopeptidase1. In patients with renal failure or hepatic failurePregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Serratiopeptidase1. Antiinflammatory
2. Antiswelling
3. Anti- rheumatoid
4. To promote transfer of antibiotics to the site of action
5. To promote lysis and discharge of sputum and pus
6. Bronchitis
7. Fibrocystic breast swelling
8. Sinusitis
9. Cough
10. Laryngitis
11. Fibromyalgia
12. Emphysema
13. Gout
Interactions for SerratiopeptidaseN/ATypical Dosage for SerratiopeptidaseOral-
Adults-5 to 10mg tab every 3 times daily.
10- 30 mg tab /day.
Schedule of SerratiopeptidaseN/AStorage Requirements for SerratiopeptidaseStore below 25 degree Celsius, protect from light and moisture.Effects of Missed Dosage of SerratiopeptidaseTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of SerratiopeptidaseGive supportive measures and symptomatic treatment.Home Delivery for Diclofenac Sodium + Serratiopeptidase in Your City
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