Buclizine Pharmacology

Buclizine

About Buclizine

Piperazine derivative, Antihistamine, Anticholinergic, Antivertigo/antiemetic.

Mechanism of Action of Buclizine

Buclizine produces Antiemetic action by its central action on Chemoreceptor trigger zone (CTZ). It decreases the sensitivity of Labyrinth apparatus which transmit stimuli to the CTZ and stimulates the vomiting center.
Buclizine is a potent H1 receptor antihistaminic agent. It has anticholinergic activity also

Pharmacokinets of Buclizine

Absorption: It is well absorbed after oral administration. Distribution: It is very widely distributed in the body. Metabolism: It is metabolised in the liver. Excretion: Drug is excreted in faeces and also in urine.

Onset of Action for Buclizine

N/A

Duration of Action for Buclizine

N/A

Half Life of Buclizine

6 hours

Side Effects of Buclizine

1.Drowsiness
2.Dry mouth
3.Restlessness
4.Urine retention
5.Blurred vision
6.Constipation
7.Abdominal discomfort

Contra-indications of Buclizine

1.Hypersensitivity to Buclizine

Special Precautions while taking Buclizine

1.Glaucoma
2.Asthma
3.Prostate hypertrophy
4.Alcoholics
5.Patient should be cautioned about driving vehicle or operating machines

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated.

Children Related Information

Use with caution
CHILDREN below12 years: contraindicated
NEONATES: contraindicated

Indications for Buclizine

1.Dizziness
2.Motion sickness

Interactions for Buclizine

N/A

Typical Dosage for Buclizine

Oral
To prevent motion sickness:
Adults: 50 mg to be taken 30 minutes before travel. The dose may be repeated every 4 to 6 hours if needed. Not more than 150 mg should be taken in one day.
Children:As directed by the physician

Schedule of Buclizine

Storage Requirements for Buclizine

Store the drug at room temperature in a tightly closed container. Protect from heat and light.

Effects of Missed Dosage of Buclizine

Take the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Buclizine

Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage.

Home Delivery for Buclizine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including buclizine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for buclizine and other medicines and health products. Home delivery services for buclizine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take buclizine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for buclizine before they complete the sale. You can get this information while placing the order for buclizine with the pharmacy.

Buclizine is a generic medicine name and there are several brands available for it. Some of the brands for buclizine might be better known than buclizine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have buclizine in stock, you can ask for one of the branded alternatives for buclizine.