Mizolastine Pharmacology

Mizolastine

About Mizolastine
Second generation H1 antagonist, Benzimidazole derivative , Non-sedating antihistamine.
Mechanism of Action of Mizolastine
Mizolastine acts by blocking the binding of histamine (Histamine is a chemical produced by the body and stored in cells (mast cells) in almost all tissues of the body. When the body reacts to a foreign substance the mast cells release their stores of histamine. Histamine may then bind to receptors (H-1 receptors) in many areas of the body causing an increase in blood flow to the area of the allergy and the release of other chemicals that cause allergic symptoms such as inflammation of the skin, airways or tissues, rashes, itching of the skin, eyes or nose, nasal congestion or narrowing of the airways) to receptors in the body. It does not prevent the norml release of histamine from mast cells.
Pharmacokinets of Mizolastine
Absorption- Moderately absorbed after oral administration
Distribution- Rapidly and widely distributed in the body.Above 98% bound to the plasma proteins
Metabolism- Metabolized in the liver to its metabolites by glucoronidation and sulphation
Excretion- Excreted through feces

Onset of Action for Mizolastine
Below 2 hrs
Duration of Action for Mizolastine
24hrs
Half Life of Mizolastine
13 hrs
Side Effects of Mizolastine
1. Headache
2. Dry mouth
3. Diarrhoea
4. Drowsiness
5. Arrhythmias
6. Dyspepsia
7. Asthenia
8. Increased appetite
9. Weight gain
Contra-indications of Mizolastine
1. Hypersensitivity to the drug or its ingredient
2. Symptomatic arrhythmias
3. Hypokalaemia
4. Suspected QT prolongation
5. Decreased liver function
6. Bradycardia
Special Precautions while taking Mizolastine
1. Diabetes
2. Hepatic impairement
3. Any work which require mental alertness like driving and machine operations
Pregnancy Related Information
Contraindicated
Old Age Related Information
Contraindicated
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Mizolastine
1. Urticaria
2. Rhinitis
3. Conjunctivitis
Interactions for Mizolastine
Erythromycin, ketoconazole: Drug levels of mizolastine may increase. Do not co-prescribe.
Amiodarone, quinidine, sotalol: Do not co-prescribe.
Cimetidine, cyclosporin, nifedipine:These drugs should be taken with caution with mizolastine
Typical Dosage for Mizolastine
Oral-
Adult-
10mg once daily
Schedule of Mizolastine
N/A
Storage Requirements for Mizolastine
Store in a cool, dry place, away from direct light and heat. Keep out of reach of children.
Effects of Missed Dosage of Mizolastine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Mizolastine
Give symptomatic and supportive treatment

Home Delivery for Mizolastine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including mizolastine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for mizolastine and other medicines and health products. Home delivery services for mizolastine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take mizolastine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for mizolastine before they complete the sale. You can get this information while placing the order for mizolastine with the pharmacy.

Mizolastine is a generic medicine name and there are several brands available for it. Some of the brands for mizolastine might be better known than mizolastine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mizolastine in stock, you can ask for one of the branded alternatives for mizolastine.