Levocetirizine Pharmacology

Levocetirizine

About Levocetirizine
A third-generation non-sedative H1 antagonist, Antihistamine.
Mechanism of Action of Levocetirizine
This active enantiomer of cetrizine is a potent, nonsedative and selective H1 receptor antagonist. It antagonizes the allergic symptoms produced by histamines like runny nose, cold, cough etc. It also inhibit eotaxin-induced eosinophil TEM through both dermal and lung micro vascular endothelial cells. So inhibit eosinophil chemotaxis and also inflammation caused by it.
Pharmacokinets of Levocetirizine
Absorption- Well absorbed after oral administration.
Distribution-Widely distributed in the body.90% bound to the plasma proteins.
Metabolism- Metabolized in the liver to its metabolites.
Excretion- Excreted via urine and feces.
Onset of Action for Levocetirizine
N/A
Duration of Action for Levocetirizine
N/A
Half Life of Levocetirizine
Its plasma half life is 6-10hrs
Side Effects of Levocetirizine
1. Headache
2. Abdominal pain
3. Dry mouth
4. Fatigue
5. Pharyngitis
6. Sleepiness
7. Asthenia
8. Rhinitis causing a blocked or runny nose
9. Migraine

Contra-indications of Levocetirizine
1. Allergy to drug or other medicines that contain piperazine derivatives
2. Hereditary galactose intolerance
3. Hereditary Lapp lactase deficiency
4. Inherited glucose-galactose malabsorption
5. Severely decreased kidney function
Special Precautions while taking Levocetirizine
1. Decreased kidney function
2. Avoid alcohol or any work which require mental alertness like driving and machine operation during treatment.


Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Levocetirizine
1. Rhinitis (seasonal and perennial)
2. Idiopathic urticaria
Interactions for Levocetirizine
Coadministration with alcohol or other CNS depressants may have additional CNS depressant effect.
Typical Dosage for Levocetirizine
Oral-
Adult-5mg/day.
Children (>6yrs) - 5mg/day.
Schedule of Levocetirizine
N/A
Storage Requirements for Levocetirizine
Store in a cool, dry place, away from direct light and heat.
Keep out of reach of children.
Effects of Missed Dosage of Levocetirizine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Levocetirizine
Give symptomatic and supportive treatment.

Home Delivery for Levocetirizine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including levocetirizine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for levocetirizine and other medicines and health products. Home delivery services for levocetirizine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take levocetirizine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for levocetirizine before they complete the sale. You can get this information while placing the order for levocetirizine with the pharmacy.

Levocetirizine is a generic medicine name and there are several brands available for it. Some of the brands for levocetirizine might be better known than levocetirizine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have levocetirizine in stock, you can ask for one of the branded alternatives for levocetirizine.