Fluticasone Inhalers Pharmacology

Fluticasone Inhalers

About Fluticasone Inhalers
Inhaled glucocorticoid, Asthma prophylactic(Anti inflammatory).
Mechanism of Action of Fluticasone Inhalers
Fluticasone is a medium potency steroid. The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits Phospholipase A2 and thus decreases the production of Prostaglandins, leukotrienes (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gamma interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.

Pharmacokinets of Fluticasone Inhalers
Absorption- Poorly absorbed into systemic absorption after intranasal administration
Distribution- Widely distributed in the body as protein binding form (91%)
Metabolism- Metabolized in liver and intranasal into its metabolites
Excretion- Excreted through urine

Onset of Action for Fluticasone Inhalers
N/A
Duration of Action for Fluticasone Inhalers
N/A
Half Life of Fluticasone Inhalers
Its plasma half life is 10 hours
Side Effects of Fluticasone Inhalers
1. Abdominal pain
2. Chest pain
3. Coughing
4. Hoarseness
5. Dizziness
6. Lightheadedness
7. Fever or chills
8. Skin rash
9. Itching
10. Sore mouth
11. Troubled breathing or wheezing
12. Unusual swelling
14. Unusual tiredness or weakness
15. Throat irritation
16. Dry mouth
17. Flushing
18. Loss of taste, or unpleasant taste
Contra-indications of Fluticasone Inhalers
1. Hypersensitivity to the drug or other corticosteroids, tetrafluoroethane, medicines, foods, dyes, or preservatives.
2. Asthmatic attack (acute)
3. Infection
Special Precautions while taking Fluticasone Inhalers
N/A
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Fluticasone Inhalers
1. Asthma
2. Allergic rhinitis

Interactions for Fluticasone Inhalers
N/A
Typical Dosage for Fluticasone Inhalers
Intranasal-
Adult-
2 sprays (50mcg/actuation) in each nostril once or two times daily- Allergic rhinitis
Adults and children >12 -
Asthma:88 to 220mcg inhalation aerosol two times daily or 50 - 100mcg inhalation powder 2 times daily

Schedule of Fluticasone Inhalers
N/A
Storage Requirements for Fluticasone Inhalers
Store it at room temperature and away from excess heat and moisture
Effects of Missed Dosage of Fluticasone Inhalers
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Fluticasone Inhalers
Give symptomatic and supportive treatment

Home Delivery for Fluticasone Inhalers in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including fluticasone inhalers.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for fluticasone inhalers and other medicines and health products. Home delivery services for fluticasone inhalers may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take fluticasone inhalers only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for fluticasone inhalers before they complete the sale. You can get this information while placing the order for fluticasone inhalers with the pharmacy.

Fluticasone Inhalers is a generic medicine name and there are several brands available for it. Some of the brands for fluticasone inhalers might be better known than fluticasone inhalers itself. If the pharmacy that's willing to deliver medicines to your home doesn't have fluticasone inhalers in stock, you can ask for one of the branded alternatives for fluticasone inhalers.