Montelukast Pharmacology

Montelukast

About Montelukast

Leukotriene(CysLT1) Receptor Antagonist, Antiinflammatory,antiasthma.

Mechanism of Action of Montelukast

Montelukast is competitively and selectively antagonizes CysLT1 receptor (leukotrienes receptor) mediated Bronchoconstriction.Montelukast inhibits physiologic actions of LTD 4 at the CysLT1 receptor without any agonist activity.

Pharmacokinets of Montelukast

Absorption: Montelukast is rapidly absorbed after oral administration and its bioavailability is about 60 - 70%.
Distribution: It is minimally distributed to the tissues in protein bound form (99%)
Metabolism: It is extensively metabolised in the liver.
Excretion: Montelukast is excreted in the faeces.

Onset of Action for Montelukast

N/A

Duration of Action for Montelukast

N/A

Half Life of Montelukast

2.75 - 5.5 hours

Side Effects of Montelukast

1.Headache
2.Dizziness
3.Nasal congestion
4.Sore throat
5.Abdominal pain
6.Fatigue
7.Asthenia
8.Cough
9.Influenza
10.Rash
11.Fever
12.Trauma
13.Trauma
14.Dyspepsia

Contra-indications of Montelukast

1.Hypersensitivity to Montelukast
2.Acute asthmatic attacks

Special Precautions while taking Montelukast

N/A

Pregnancy Related Information

Use with caution.

Old Age Related Information

May be used.

Breast Feeding Related Information

Use with caution.

Children Related Information

May be used
CHILDREN below 6 years : contraindicated
NEONATES: contraindicated

Indications for Montelukast

Asthma.

Interactions for Montelukast

Barbiturates & Primidone: Plasma concentration of montelukast is reduced by phenobarbital.

Typical Dosage for Montelukast

Adult: 10 mg / day at bed time
Children (6 - 14 years): 5mg/day at bed time

Schedule of Montelukast

N/A

Storage Requirements for Montelukast

Store at room temperature. Protect from heat and light. Keep out of the reach of children.

Effects of Missed Dosage of Montelukast

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Montelukast

Give supportive measures and symptomatic treatment

Home Delivery for Montelukast in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including montelukast.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for montelukast and other medicines and health products. Home delivery services for montelukast may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take montelukast only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for montelukast before they complete the sale. You can get this information while placing the order for montelukast with the pharmacy.

Montelukast is a generic medicine name and there are several brands available for it. Some of the brands for montelukast might be better known than montelukast itself. If the pharmacy that's willing to deliver medicines to your home doesn't have montelukast in stock, you can ask for one of the branded alternatives for montelukast.