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- Pharmacology For Salbutamol (Inhalers) + Ipratropium Bromide
Salbutamol (Inhalers) + Ipratropium Bromide Pharmacology
Salbutamol (Inhalers) + Ipratropium Bromide
About Salbutamol (Inhalers) + Ipratropium BromideN/AMechanism of Action of Salbutamol (Inhalers) + Ipratropium BromideN/APharmacokinets of Salbutamol (Inhalers) + Ipratropium BromideN/AOnset of Action for Salbutamol (Inhalers) + Ipratropium BromideN/ADuration of Action for Salbutamol (Inhalers) + Ipratropium BromideN/AHalf Life of Salbutamol (Inhalers) + Ipratropium BromideN/ASide Effects of Salbutamol (Inhalers) + Ipratropium BromideN/AContra-indications of Salbutamol (Inhalers) + Ipratropium BromideN/ASpecial Precautions while taking Salbutamol (Inhalers) + Ipratropium BromideN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Salbutamol (Inhalers) + Ipratropium BromideN/AInteractions for Salbutamol (Inhalers) + Ipratropium BromideN/ATypical Dosage for Salbutamol (Inhalers) + Ipratropium BromideN/ASchedule of Salbutamol (Inhalers) + Ipratropium BromideN/AStorage Requirements for Salbutamol (Inhalers) + Ipratropium BromideN/AEffects of Missed Dosage of Salbutamol (Inhalers) + Ipratropium BromideN/AEffects of Overdose of Salbutamol (Inhalers) + Ipratropium BromideN/ASalbutamol (Inhalers)
About Salbutamol (Inhalers)A short acting Beta2-Adrenergic Agonist, Phenethylamine derivative, Bronchodilator(Antiasthma).Mechanism of Action of Salbutamol (Inhalers)Salbutamol is a short acting ?2 receptor agonist. It directly relaxes the airway smooth muscles and produces bronchodilation. Stimulation of ?2 receptors activates Gs adenylyl-cyclase -cyclic AMP path way and produces reduction in smooth muscle tone. ?2 receptor agonists also increases the conductance of large Ca2+-sensitive K+ channels in airway smooth muscles and leads to membrane hyperpolarisation and relaxation of smooth muscles.
?2 receptor agonists also suppress the release of Leukotrienes and histamine from the mast cells in the lung tissue and enhance mucociliary function and decrease micro vascular permeability and also inhibits Phospholipase A2 which produces inhibition of prostaglandins production. Thus Salbutamol can inhibit the broncho-constriction produced by inflammatory mediators.
Pharmacokinets of Salbutamol (Inhalers)Absorption: It is gradually absorbed after oral inhalation.
Metabolism: It is metabolised to inactive metabolites in the liver.
Excretion: Salbutamol is excreted primarily in the urine (75%) and small amount in the faeces.
Onset of Action for Salbutamol (Inhalers)5 - 15 minutesDuration of Action for Salbutamol (Inhalers)2 - 6 hoursHalf Life of Salbutamol (Inhalers)N/ASide Effects of Salbutamol (Inhalers)1. Headache
2. Paradoxical Bronchospasm
3. Hypokalaemia
4. Tremor
5. Anxiety
6. Restlessness
7. Tachycardia
8. Palpitations
Contra-indications of Salbutamol (Inhalers)1. Hypersensitivity to Salbutamol and other sympathomimetic aminesSpecial Precautions while taking Salbutamol (Inhalers)1. Myocardial insufficiency
2. Arrhythmia
3. Hypertension
4. Hyperthyroidism
5. Epilepsy
6. Diabetes
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
Below 6 years: Contraindicated
NEONATES: contraindicated
Indications for Salbutamol (Inhalers)1. Obstructive airway diseases
2. Acute Bronchospasm
3. Status asthmaticusInteractions for Salbutamol (Inhalers)N/ATypical Dosage for Salbutamol (Inhalers)Adult: Salbutamol 90mcg/metered spray
Relief of Bronchospasm in patients with reversible obstructive airway disease: 1 - 2 inhalations every 6 - 8 hours
Prevention of exercise-induced Bronchospasm: 200mcg 15 - 30 minutes before exertion
Chronic therapy:Up to 200mcg four times daily
Solutions for Nebulisation: 2 .5 mg 3 - 4 times daily by using nebulisers
Capsules for inhalation: 200mcg inhaled every 6-8 hours using rotahaler device.
Children: 100mcg, the dose may be increased to 200mcg if required.
Prevention of exercise-induced Bronchospasm: 100mcg before exertion, the dose may be increased to 200mcg if required.
Chronic therapy: Up to 200mcg four times daily
Schedule of Salbutamol (Inhalers)HStorage Requirements for Salbutamol (Inhalers)Store at 15 - 30 degree C. Protect from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of Salbutamol (Inhalers)Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Salbutamol (Inhalers)Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of drug can be reduced by administration of activated charcoal.Ipratropium Bromide
About Ipratropium BromideAnticholinergic, Muscarinic antagonist,Tropane derivative, Bronchodilator( Anti asthma)Mechanism of Action of Ipratropium BromideIpratropium bromide selectively acts on bronchial muscle without altering volume or consistency of respiratory secretions. It inhibits vagally mediated reflexes by antagonizing the actions of acetylcholine. It prevents the acetylcholine mediated increase in intracellular cyclic GMP concentration that results from interaction of acetylcholine with muscarinic receptor on bronchial smooth muscle. It does not depress the muco-ciliary clearance by bronchial epithelium. It blocks the cholinergic constrictor tone and acts primarily in the larger airways.Pharmacokinets of Ipratropium BromideAbsorption: Not readily absorbed in to systemic circulation.Onset of Action for Ipratropium BromideN/ADuration of Action for Ipratropium BromideN/AHalf Life of Ipratropium BromideN/ASide Effects of Ipratropium Bromide1. Upper respiratory tract infections
2. Cough
3. Bronchitis
4. Dyspnoea
5. Bronchospasm
6. Increased sputum
7. Pharyngitis
8. Dry mouth
9. Nausea
11. Gastrointestinal distress
12. Pain
13. Headache
14. Back pain
15. Dizziness
16. Palpitation
17. Chest pain
18. Rashes
19. Flu like symptoms
20. Loss of voice
21. Nasal congestion
22. Runny nose
23. Sneezing
24. Sore throat
25. Unpleasant taste
26. Weakness
Contra-indications of Ipratropium Bromide1. Hypersensitivity to the drug
2. Hypersensitivity to Atropine or its derivatives
3. Hypersensitivity to Soya lecithin or related food substances such as soybeans and peanuts
Special Precautions while taking Ipratropium Bromide1. Angle closure glaucoma
2. Prostatic hyperplasia
3. Bladder neck obstruction
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Ipratropium Bromide1. Chronic obstructive pulmonary diseases
2. Bronchospasm
3. Chronic bronchitis
4. Emphysema
5. Rhinorrhea
6. Common cold
7. Allergic rhinitis
8. Perennial rhinitis
Interactions for Ipratropium BromideN/ATypical Dosage for Ipratropium BromideDosage individualized based on patients requirements.
Rhinorrhea, Allergic rhinitis, Perennial rhinitis:
Nasal spray (0.03%):
Adults and children over 12years: 2 sprays (42mcg) per nostril two to three times daily.
Nasal spray (0.06%):Rhinorrhea associated with common cold:
Adults and children over 12years: 2 sprays (84mcg) per nostril three to four times daily.
Children (5 to 12): 2 sprays (84mcg) per nostril three times daily
Chronic obstructive pulmonary diseases such as bronchitis, emphysema etc:
Inhalation aerosol:
Adults and children over 12 years: 2 to 4 inhalations or puffs every 8th to 6th hours. Increases if required up to 6 to 8 puffs thrice daily.
Inhalation solution:
Adults and children over 12 years: 250 to 500mcg in every 8th to 6th hours through a nebulizer
Asthma:
Inhalation aerosol:
Adults and children over 12 years: 1 to 4 inhalations or puffs every 6th hours as required. Children up to 12 years: 1 to 2 inhalations or puffs every 8th to 6th hours as required.
Children below 6 years: 1 inhalation; every 8th hours.
Inhalation solution:
Adults and children over 12 years: 500mcg every 8th to 6th hours through a nebulizer as required.
Children (5 to 12 hours): 125 to 250mcg through a nebulizer thrice daily. Increases up to every 4th to 6th hours if required
Schedule of Ipratropium BromideN/AStorage Requirements for Ipratropium BromideStore at controlled room temperature at a range of 15 to 30 degree C. Protect from Direct heat, light, and moisture. Avoid freezing. Keep out of reach of children. Shake well before use.Effects of Missed Dosage of Ipratropium BromideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Ipratropium BromideIt is not readily absorbed in to systemic circulation. So acute overdose is unlikely to occur. Provide symptomatic treatment and supportive measures. Home Delivery for Salbutamol (Inhalers) + Ipratropium Bromide in Your City
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Salbutamol (Inhalers) + Ipratropium Bromide is a generic medicine name and there are several brands available for it. Some of the brands for salbutamol (inhalers) + ipratropium bromide might be better known than salbutamol (inhalers) + ipratropium bromide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have salbutamol (inhalers) + ipratropium bromide in stock, you can ask for one of the branded alternatives for salbutamol (inhalers) + ipratropium bromide.