Levalbuterol Pharmacology

Levalbuterol

About Levalbuterol

Adrenergic Beta2 Agonist, Phenethylamine derivative, Bronchodilator, AntiAsthma.

Mechanism of Action of Levalbuterol

Levalbuterol is the (R)-enantiomer of the racemic Albuterol. Levalbuterol is relatively selective beta2-adrenergic receptor agonist. It selectively stimulates ?2 receptors present in airway, Uterus, and Vascular Smooth muscles. It directly relaxes the airway smooth muscles and produces bronchodilation. Stimulation of ?2 receptors activates Gs adenylyl-cyclase -cyclic AMP path way and produces reduction in smooth muscle tone. ?2 receptor agonists also increases the conductance of large Ca2+sensitive K+ channels in airway smooth muscles and leads to membrane hyperpolarisation and relaxation of smooth muscles. ?2 receptor agonists also suppress the release of Leukotrienes and histamine from the mast cells in the lung tissue and enhance mucociliary function and decrease micro vascular permeability and also inhibit Phospholipase A2 which produces inhibition of prostaglandins production. Thus Levalbuterol can inhibit the broncho-constriction produced by inflammatory mediators.Using Levalbuterol instead of Albuterol produces less direct effect on ?1-adrenergic receptors and fewer cardiac side effects.

Pharmacokinets of Levalbuterol

Absorption:Levalbuterol is absorbed after oral administration.

Onset of Action for Levalbuterol

N/A

Duration of Action for Levalbuterol

N/A

Half Life of Levalbuterol

N/A

Side Effects of Levalbuterol

1.Heart rate
2.Tremor
3.Nervousness

Contra-indications of Levalbuterol

Hypersensitivity to Levalbuterol

Special Precautions while taking Levalbuterol

1.Coronary insufficiency
2.Hypertension
3.Cardiac arrhythmias
4.Convulsive disorders
5.Hyperthyroidism
6. Diabetes mellitus

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

Children:Below 12 years:contraindicated

Indications for Levalbuterol

1.Asthma
2.Paradoxical Bronchospasm

Interactions for Levalbuterol

N/A

Typical Dosage for Levalbuterol

Oral:
ADULT AND CHILDREN: 0.63 mg 3- 4 times a day
Asthma: 1.25 mg three times a day.

Schedule of Levalbuterol

N/A

Storage Requirements for Levalbuterol

Store at 15 - 30 degree C. Protect from heat and light. Keep out of the reach of children

Effects of Missed Dosage of Levalbuterol

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Levalbuterol

Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of drug can be reduced by administration of activated charcoal.

Home Delivery for Levalbuterol in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including levalbuterol.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for levalbuterol and other medicines and health products. Home delivery services for levalbuterol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take levalbuterol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for levalbuterol before they complete the sale. You can get this information while placing the order for levalbuterol with the pharmacy.

Levalbuterol is a generic medicine name and there are several brands available for it. Some of the brands for levalbuterol might be better known than levalbuterol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have levalbuterol in stock, you can ask for one of the branded alternatives for levalbuterol.