Guaiphenesin + Levocetirizine + Ambroxol Pharmacology

Guaiphenesin + Levocetirizine + Ambroxol

About Guaiphenesin + Levocetirizine + Ambroxol
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Mechanism of Action of Guaiphenesin + Levocetirizine + Ambroxol
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Pharmacokinets of Guaiphenesin + Levocetirizine + Ambroxol
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Onset of Action for Guaiphenesin + Levocetirizine + Ambroxol
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Duration of Action for Guaiphenesin + Levocetirizine + Ambroxol
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Half Life of Guaiphenesin + Levocetirizine + Ambroxol
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Side Effects of Guaiphenesin + Levocetirizine + Ambroxol
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Contra-indications of Guaiphenesin + Levocetirizine + Ambroxol
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Special Precautions while taking Guaiphenesin + Levocetirizine + Ambroxol
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Guaiphenesin + Levocetirizine + Ambroxol
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Interactions for Guaiphenesin + Levocetirizine + Ambroxol
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Typical Dosage for Guaiphenesin + Levocetirizine + Ambroxol
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Schedule of Guaiphenesin + Levocetirizine + Ambroxol
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Storage Requirements for Guaiphenesin + Levocetirizine + Ambroxol
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Effects of Missed Dosage of Guaiphenesin + Levocetirizine + Ambroxol
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Effects of Overdose of Guaiphenesin + Levocetirizine + Ambroxol
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Guaiphenesin

About Guaiphenesin
Propanediol derivative, Expectorant.
Mechanism of Action of Guaiphenesin
Guaiphenesin is an expectorant which after absorption from the gastrointestinal tract secreted by tracheobronchial glands and directly increase bronchial secretion and mucosal ciliary action. It increases respiratory tract fluid by reducing adhesiveness and surface tension, reducing viscosity of the secretions and there by facilitating their removal and clears chest congestion.
Action in local vaginal preparations: Guaiphenesin helps to thin the thick or sticky cervical mucus.

Pharmacokinets of Guaiphenesin
Absorption: Well absorbed orally.Distribution: It is secreted by the tracheobronchial glands.
Metabolism: It is metabolized primarily to Beta-2-methoxyphenoxy-lactic acid. Excretion: It is excreted in the urine.
Onset of Action for Guaiphenesin
N/A
Duration of Action for Guaiphenesin
N/A
Half Life of Guaiphenesin
60 minutes
Side Effects of Guaiphenesin
1. Headache
2. Dizziness
3. Nausea
4. Vomiting
5. Rash
6. Diarrhoea
7. Drowsiness
8. Stomach pain
Contra-indications of Guaiphenesin
1. Hypersensitivity to the drug
2. Chronic or persistent cough associated with chronic lower respiratory tract diseases
3. Asthma
4. Bronchitis
5. Chronic obstructive pulmonary disease (COPD)
6. Emphysema
Special Precautions while taking Guaiphenesin
1. Porphyria
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
May be used
Indications for Guaiphenesin
1. Expectorant
2. Thick or sticky cervical mucus
Interactions for Guaiphenesin
N/A
Typical Dosage for Guaiphenesin
Oral :
Adults and children over 12 years: 100 to 400mg up to 6 times daily as required.Maximum dose: 2.4g/day
Children (age 6 to 11): 100 to 200mg up to 6 times daily as required.Maximum dose: 1.2g/day
Children (age 2 to 5): 50 to 100mg up to 6 times daily as required.Maximum dose: 600mg/day
Extended release:
Adults and children over 12 years: 600 to 1200mg twice daily. Not to exceed 2.4g in 24 hours
Children (age 6 to 12): 600mg twice daily. Not to exceed 1.2g in 24 hours
Children (age 2 to 6): 300mg twice daily. Not to exceed 600mg in 24 hours
Thick or sticky cervical mucus: 200mg 2 to 3 times daily from 4 days prior to ovulation and continue through ovulation day.
Schedule of Guaiphenesin
N/A
Storage Requirements for Guaiphenesin
Store at a temperature below 30 degree C. Keep out of reach of children.
Effects of Missed Dosage of Guaiphenesin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Guaiphenesin
Provide symptomatic treatment and supportive measures.

Levocetirizine

About Levocetirizine
A third-generation non-sedative H1 antagonist, Antihistamine.
Mechanism of Action of Levocetirizine
This active enantiomer of cetrizine is a potent, nonsedative and selective H1 receptor antagonist. It antagonizes the allergic symptoms produced by histamines like runny nose, cold, cough etc. It also inhibit eotaxin-induced eosinophil TEM through both dermal and lung micro vascular endothelial cells. So inhibit eosinophil chemotaxis and also inflammation caused by it.
Pharmacokinets of Levocetirizine
Absorption- Well absorbed after oral administration.
Distribution-Widely distributed in the body.90% bound to the plasma proteins.
Metabolism- Metabolized in the liver to its metabolites.
Excretion- Excreted via urine and feces.
Onset of Action for Levocetirizine
N/A
Duration of Action for Levocetirizine
N/A
Half Life of Levocetirizine
Its plasma half life is 6-10hrs
Side Effects of Levocetirizine
1. Headache
2. Abdominal pain
3. Dry mouth
4. Fatigue
5. Pharyngitis
6. Sleepiness
7. Asthenia
8. Rhinitis causing a blocked or runny nose
9. Migraine

Contra-indications of Levocetirizine
1. Allergy to drug or other medicines that contain piperazine derivatives
2. Hereditary galactose intolerance
3. Hereditary Lapp lactase deficiency
4. Inherited glucose-galactose malabsorption
5. Severely decreased kidney function
Special Precautions while taking Levocetirizine
1. Decreased kidney function
2. Avoid alcohol or any work which require mental alertness like driving and machine operation during treatment.


Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Levocetirizine
1. Rhinitis (seasonal and perennial)
2. Idiopathic urticaria
Interactions for Levocetirizine
Coadministration with alcohol or other CNS depressants may have additional CNS depressant effect.
Typical Dosage for Levocetirizine
Oral-
Adult-5mg/day.
Children (>6yrs) - 5mg/day.
Schedule of Levocetirizine
N/A
Storage Requirements for Levocetirizine
Store in a cool, dry place, away from direct light and heat.
Keep out of reach of children.
Effects of Missed Dosage of Levocetirizine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Levocetirizine
Give symptomatic and supportive treatment.

Ambroxol

About Ambroxol
Active N-desmethyl metabolite of bromhexine,systemically active mucolytic agent, Secretomotoric and expectoration improver.
Mechanism of Action of Ambroxol
Ambroxol hydrochloride acts as an expectoration improver and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and by breaking network of fibres in tenacious sputum . It induces thin copious bronchial secretion and possesses antioxidant properties.
Pharmacokinets of Ambroxol
N/A
Onset of Action for Ambroxol
N/A
Duration of Action for Ambroxol
N/A
Half Life of Ambroxol
N/A
Side Effects of Ambroxol
1. Rhinorrhoea
2. Lacrimations
3. Allergic reactions
4. Gastric irritation.
Contra-indications of Ambroxol
Hypersensitivity to the Ambroxol hydrochloride or Bromhexine.
Special Precautions while taking Ambroxol
1.Hepatic impairment
2.Renal impairment
3.Gastric and duodenal ulcer
4.Convulsive disorders
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Ambroxol
1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
3. Bronchitis
4. Pharyngitis
5. Laryngitis
6. Rhinitis
7. Sinusitis
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10. Chronic Pneumonia.
Interactions for Ambroxol
N/A
Typical Dosage for Ambroxol
Oral: 15mg to 30mg three times daily.
Children (6 to 12years): 5ml 2 to 3 times daily
Children (2 to 6years): 2.5ml thrice daily. (5ml liquid contains 30mg Ambroxol hydrochloride)
Children up to 2 years: 7.5mg two times daily
Schedule of Ambroxol
H
Storage Requirements for Ambroxol
Store in a cool dry place and protect from light. Keep out of reach of children.
Effects of Missed Dosage of Ambroxol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Ambroxol
Provide symptomatic treatment and supportive measures.

Home Delivery for Guaiphenesin + Levocetirizine + Ambroxol in Your City

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Guaiphenesin + Levocetirizine + Ambroxol is a generic medicine name and there are several brands available for it. Some of the brands for guaiphenesin + levocetirizine + ambroxol might be better known than guaiphenesin + levocetirizine + ambroxol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have guaiphenesin + levocetirizine + ambroxol in stock, you can ask for one of the branded alternatives for guaiphenesin + levocetirizine + ambroxol.