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- Pharmacology For Dextropropoxyphene + Dexchlorpheniramine Maleate + Bromhexine
Dextropropoxyphene + Dexchlorpheniramine Maleate + Bromhexine Pharmacology
Dextropropoxyphene + Dexchlorpheniramine Maleate + Bromhexine
About Dextropropoxyphene + Dexchlorpheniramine Maleate + BromhexineN/AMechanism of Action of Dextropropoxyphene + Dexchlorpheniramine Maleate + BromhexineN/APharmacokinets of Dextropropoxyphene + Dexchlorpheniramine Maleate + BromhexineN/AOnset of Action for Dextropropoxyphene + Dexchlorpheniramine Maleate + BromhexineN/ADuration of Action for Dextropropoxyphene + Dexchlorpheniramine Maleate + BromhexineN/AHalf Life of Dextropropoxyphene + Dexchlorpheniramine Maleate + BromhexineN/ASide Effects of Dextropropoxyphene + Dexchlorpheniramine Maleate + BromhexineN/AContra-indications of Dextropropoxyphene + Dexchlorpheniramine Maleate + BromhexineN/ASpecial Precautions while taking Dextropropoxyphene + Dexchlorpheniramine Maleate + BromhexineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Dextropropoxyphene + Dexchlorpheniramine Maleate + BromhexineN/AInteractions for Dextropropoxyphene + Dexchlorpheniramine Maleate + BromhexineN/ATypical Dosage for Dextropropoxyphene + Dexchlorpheniramine Maleate + BromhexineN/ASchedule of Dextropropoxyphene + Dexchlorpheniramine Maleate + BromhexineN/AStorage Requirements for Dextropropoxyphene + Dexchlorpheniramine Maleate + BromhexineN/AEffects of Missed Dosage of Dextropropoxyphene + Dexchlorpheniramine Maleate + BromhexineN/AEffects of Overdose of Dextropropoxyphene + Dexchlorpheniramine Maleate + BromhexineN/ADextropropoxyphene
About DextropropoxypheneA synthetic morphine derivative,Opioid-like agonist,optical isomer of Levopropoxyphene, Narcotic Analgesic, anti-tussive and local anesthetic.Mechanism of Action of DextropropoxypheneIt acts on the CNS Opioid receptors. It has agonist action on mu Opioid receptors. It primarily binds to the mu Opioid receptors and produce analgesia. Its CNS effects are same as morphine. It gives in combination with other Non Steroidal Anti Inflammatory Drugs or other analgesics usually.
Pharmacokinets of DextropropoxypheneAbsorption-Orally absorbed; primarily to the upper small intestine.
Distribution-Widely distributed in the body. Enters the cerebrospinal fluid and cross the placenta.
Metabolism-In liver it is metabolized by N-demethylation. Norpropoxyphene is its active metabolite. It has more half life than parent drug. It causes toxicity at sometime due to its metabolites accumulation in the body.
Excretion-It is excreted through urine.
Onset of Action for Dextropropoxyphene30 to 60 min. after oral administrationDuration of Action for Dextropropoxyphene4 to 6 hrsHalf Life of DextropropoxyphenePlasma half life is 6 to 12 hrsSide Effects of Dextropropoxyphene1. Nausea
2. Vomiting
3. Epigastric distress
4. Sedation
5. Dizziness
6. Urticaria
7. Visual disturbances
8. Physiological dependence
Contra-indications of Dextropropoxyphene1. Hypersensitivity to this drug
2. Respiratory depression
3. Children below 12 years
Special Precautions while taking Dextropropoxyphene1. In patients with hepatic failure or renal failure used cautiously
2. Patient can not drive or operate machinery after the drug administration. So the care should be taken
3. Use cautiously in patients with suicidal mentality
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Dextropropoxyphene1. Relieve moderate to severe pain in various conditions
2. Opioid withdrawal
Interactions for DextropropoxypheneBarbiturate anaesthetics: May increase respiratory and CNS depressive effects of propoxyphene.
Warfarin: Potentiation of hypoprothrombinemic effect.
Carbamazipine: May increase serum carbamzipine levels with resultant toxicity.Typical Dosage for DextropropoxypheneOral-
Adults - 65mg 3 to 4 times daily.
Schedule of DextropropoxypheneHStorage Requirements for DextropropoxypheneStore controlled room temperature i.e. between 15 and 30 degree CelsiusEffects of Missed Dosage of DextropropoxypheneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DextropropoxypheneProvide supportive and symptomatic treatment. Establish artificial respiratory exchange. In the case of respiratory or cardiovascular depression administer a narcotic antagonist i.e. naloxone.Induce emesis or gastric lavage if the patient shows symptoms within 2hrs after drug administration. Avoid the risk of aspiration. For the further removal of drug, administer activated charcoal via nasogastric tube. Continue the supportive treatment and closely monitor the laboratory parameters, vital signs, neurological status closely. In some cases dialysis may be helpful for the treatment.Dexchlorpheniramine Maleate
About Dexchlorpheniramine MaleateFirst Generation H1 Antagonist , Alkylamine derivative, Antihistamine.Mechanism of Action of Dexchlorpheniramine MaleateDexchlorpheniramine exerts its action by acting as an H1 receptor antagonist. It antagonizes most of the pharmacological actions of Histamine and reduces allergic symptoms. It also has anticholinergic properties and reduces secretions.Pharmacokinets of Dexchlorpheniramine MaleateAbsorption: Slowly absorbed orally, bioavailability is about 25 to 50%. Distribution: Widely distributed in a protein bound form, Metabolism: Extensively metabolized in the body, Excretion: Excreted through urine both as metabolites and parent drug.Onset of Action for Dexchlorpheniramine MaleateN/ADuration of Action for Dexchlorpheniramine Maleate4 - 8 hoursHalf Life of Dexchlorpheniramine Maleate20 to 24 hoursSide Effects of Dexchlorpheniramine Maleate1.Sedation
2.Sleepiness
3.Dizziness
4.Motor incordination
5.Fatigue
6.Confusion
7.Restlessness
8.Nervousness
9.Excitation
10.Insomnia
11.Euphoria
12.Paresthesias
13.Blurred vision
14.Diplopia
15.Anorexia
16.Nausea
17.Vomiting
18.Epigastric distress
19.Diarrhoea
20.Constipation
21.Urinary frequency
22.Difficult urination
23.Urinary retention
24.Thickening of bronchial secretions
25.Tightness of chest
26.Wheezing
27.Nasal stuffiness
29.Allergic reactions
30.Palpitatoions
31.Tachycardia
32. Dryness of mouth,nose and throat.Contra-indications of Dexchlorpheniramine Maleate1.Hypersensitivity to the drug
2.Asthma
3.Lower respiratory tract diseases
4.Patients on MAO inhibitor therapy
Special Precautions while taking Dexchlorpheniramine Maleate1. Increased intraocular pressure
2.Hyperthyroidism
3.Cardiovascular disease
4.Hypertension
5.Driving or any work requiring mental alertness
6.Avoid alcohol use
7.Along with other medication
8. Narrow angle glaucoma
9.Peptic ulcer
10.Pyloroduodenal obstruction
11.Prostatic hypertrophy
12.Bladder neck obstruction
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
Neonates: ContraindicatedIndications for Dexchlorpheniramine Maleate1. Common cold
2.Allergic symptoms
3.Sneezing
4.Itching
5.Runny nose
6.Aleergic rhinitis
7.Vasomotor rhinitis
8.Allergic conjunctivitis.
Interactions for Dexchlorpheniramine MaleateN/ATypical Dosage for Dexchlorpheniramine MaleateDosage individualized based on condition and requirement of the patient.
Adults and Children over12 years: 2 mg at every 4 to 6 hours as required.
Children 6 to 12 years: 1 mg at every 4 to 6 hours as required
Children 2 to 6 years: 0.5 mg at every 4 to 6 hours as required
Schedule of Dexchlorpheniramine MaleateN/AStorage Requirements for Dexchlorpheniramine MaleateStore at room temperature at a range of 20 to 25 degree C. Protect from moisture, light and heat. Keep out of reach of children.Effects of Missed Dosage of Dexchlorpheniramine MaleateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Dexchlorpheniramine MaleateProvide symptomatic treatment and supportive measures. If vomiting has not occurred spontaneously the patient should be induced to vomit. This is done by having the patient drink a glass of water or milk after which the patient should be made to gag. Precautions against aspiration must be taken, especially in children. Saline cathartics, such as milk of magnesia, draw water into the bowel by osmosis and therefore, are valuable for their action in rapid dilution of bowel content. Vasopressors may be used to treat hypotension.Bromhexine
About BromhexineMucolytic (secretolytic)Mechanism of Action of BromhexineBromhexine hydrochloride acts as a mucokinetic and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and network of fibres in tenacious sputum is broken. It induces thin copious bronchial secretion.Pharmacokinets of BromhexineAbsorption: Bromhexine hydrochloride is rapidly absorbed from the gastrointestinal tract and bioavailability is about 20%. Distribution: It is widely distributed to body tissues in a highly protein bound form; Bromhexine crosses the blood brain barrier and small amounts cross the placenta, Metabolism: It undergoes extensive first-pass metabolism in the liver. Excretion: It is excreted primarily in the urine mainly as metabolites.Onset of Action for BromhexineN/ADuration of Action for BromhexineN/AHalf Life of Bromhexine12hours.Side Effects of Bromhexine1 Rhinorrhoea
2 Lacrimations
3.Allergic reactions
4.Gastric irritation.Contra-indications of BromhexineHypersensitivity to the drug.Special Precautions while taking Bromhexine1. Hepatic impairment
2. Renal impairment
3. Gastric and duodenal ulcer
4. Convulsive disorders
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Bromhexine1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
3. Bronchitis
4. Pharyngitis
5. Laryngitis
6. Rhinitis
7. Sinusitis
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10.Chronic Pneumonia.Interactions for BromhexineN/ATypical Dosage for BromhexineOral: 8mg thrice daily.
Children (5 to 10 years): 4mg thrice daily
Children (1 to 5 years): 4mg twice daily.
Schedule of BromhexineHStorage Requirements for BromhexineStore in a cool dry place and protect from light. Keep out of reach of children.Effects of Missed Dosage of BromhexineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of BromhexineProvide symptomatic treatment and supportive measures.Home Delivery for Dextropropoxyphene + Dexchlorpheniramine Maleate + Bromhexine in Your City
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