Phenylpropanolamine + Chlorpheniramine Maleate + Bromhexine Pharmacology

Phenylpropanolamine + Chlorpheniramine Maleate + Bromhexine

About Phenylpropanolamine + Chlorpheniramine Maleate + Bromhexine

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Mechanism of Action of Phenylpropanolamine + Chlorpheniramine Maleate + Bromhexine

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Pharmacokinets of Phenylpropanolamine + Chlorpheniramine Maleate + Bromhexine

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Onset of Action for Phenylpropanolamine + Chlorpheniramine Maleate + Bromhexine

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Duration of Action for Phenylpropanolamine + Chlorpheniramine Maleate + Bromhexine

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Half Life of Phenylpropanolamine + Chlorpheniramine Maleate + Bromhexine

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Side Effects of Phenylpropanolamine + Chlorpheniramine Maleate + Bromhexine

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Contra-indications of Phenylpropanolamine + Chlorpheniramine Maleate + Bromhexine

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Special Precautions while taking Phenylpropanolamine + Chlorpheniramine Maleate + Bromhexine

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Pregnancy Related Information

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Old Age Related Information

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Breast Feeding Related Information

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Children Related Information

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Indications for Phenylpropanolamine + Chlorpheniramine Maleate + Bromhexine

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Interactions for Phenylpropanolamine + Chlorpheniramine Maleate + Bromhexine

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Typical Dosage for Phenylpropanolamine + Chlorpheniramine Maleate + Bromhexine

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Schedule of Phenylpropanolamine + Chlorpheniramine Maleate + Bromhexine

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Storage Requirements for Phenylpropanolamine + Chlorpheniramine Maleate + Bromhexine

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Effects of Missed Dosage of Phenylpropanolamine + Chlorpheniramine Maleate + Bromhexine

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Effects of Overdose of Phenylpropanolamine + Chlorpheniramine Maleate + Bromhexine

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Phenylpropanolamine

About Phenylpropanolamine

Alfa-and Beta-adrenergic agonist, Phenethylamine derivative, a stimulant, decongestant,anorectic.

Mechanism of Action of Phenylpropanolamine

It is a mixed acting sympathomimetic amine with predominant alpha adrenergic agonistic action. It exerts nasal decongestant action by acting through alpha adrenergic receptors in the respiratory tract mucosa; and produces vasoconstriction. It temporarily reduces the swelling associated with inflammation of nasal mucosa.
Phenylpropanolamine also suppresses the appetite control center in the hypothalamus

Pharmacokinets of Phenylpropanolamine

Absorption: Well absorbed orally, Metabolism: Metabolized in to an active metabolite in liver, Excretion: Excreted mainly through urine.

Onset of Action for Phenylpropanolamine

15 to 30 minutes

Duration of Action for Phenylpropanolamine

3 hours

Half Life of Phenylpropanolamine

N/A

Side Effects of Phenylpropanolamine

1. Hypertension
2. Stroke
3. Arrhythmias
4. Renal failure
5. Rhabdomyolysis
6. Psychotic disturbances
7. Hallucinations
8. Seizures

Contra-indications of Phenylpropanolamine

1. Hypersensitivity to Phenylpropanolamine or other sympathomimetics
2. Coronary artery disease
3. Hypertension
4. Arteriosclerosis
5. Depression
6. Angle-closure glaucoma
7. Diabetes
8. Renal impairment
9. Hyperthyroidism
10. During or within 14 days of use of MAO inhibitors
11. Use as an anorexiant for children less than 12 years of age
12. Sustained-release forms during lactation and in children less than 12 years of age

Special Precautions while taking Phenylpropanolamine

1. Cardiovascular disorders
2. Mild Hypertension
3. Prostatic hypertrophy
4. Psychosis or other psychiatric disorders (Phenylpropanolamine may precipitate psychiatric disorders)
5. Not drinking large amounts of caffeine-containing beverages, such as coffee, tea, or colas
6. Do not engage in driving, using machines, or doing anything else that requires mental alertness while taking medication
7. Inform the physician if cold symptoms do not improve within 7 days or if fever is present

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

Use with caution

Indications for Phenylpropanolamine

1. Nasal congestion

Interactions for Phenylpropanolamine

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Typical Dosage for Phenylpropanolamine

Oral:
Adults:
As decongestant: 25mg every four hours or 50mg every 8 hours daily. Not to exceed 150mg/day
Anorexiant: 25mg thrice daily; 30minutes before meals.
Extended release tablets or capsules:As decongestant: 75mg twice daily
Anorexiant: 75mg once daily in the morning.
As decongestant:
Children (6 to 12 years): 12.5mg up to every four hours. Not to exceed 75mg/day
Children (2 to 6years): 6.25mg up to every four hours. Not to exceed 37.5mg/day

Schedule of Phenylpropanolamine

Storage Requirements for Phenylpropanolamine

Store at controlled room temperature at range of 15 to 30 degree C.; in a well closed container. Protect from light.

Effects of Missed Dosage of Phenylpropanolamine

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Phenylpropanolamine

Provide symptomatic treatment and supportive measures.Remove drug from the body by induced emesis or gastric lavage. Barbiturate sedatives are sometimes used to control excessive CNS stimulation. Monitor Cardiovascular and respiratory functions. Administer intravenous fluids to control hypotension. Correct hypertension with Intravenous phentolamine or nitrates. Perform forced diuresis by acidification of urine.

Chlorpheniramine Maleate

About Chlorpheniramine Maleate

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Mechanism of Action of Chlorpheniramine Maleate

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Pharmacokinets of Chlorpheniramine Maleate

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Onset of Action for Chlorpheniramine Maleate

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Duration of Action for Chlorpheniramine Maleate

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Half Life of Chlorpheniramine Maleate

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Side Effects of Chlorpheniramine Maleate

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Contra-indications of Chlorpheniramine Maleate

First Generation alkylamine H1 Antagonist, Antihistamine.

Special Precautions while taking Chlorpheniramine Maleate

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Pregnancy Related Information

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Old Age Related Information

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Breast Feeding Related Information

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Children Related Information

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Indications for Chlorpheniramine Maleate

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Interactions for Chlorpheniramine Maleate

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Typical Dosage for Chlorpheniramine Maleate

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Schedule of Chlorpheniramine Maleate

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Storage Requirements for Chlorpheniramine Maleate

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Effects of Missed Dosage of Chlorpheniramine Maleate

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Effects of Overdose of Chlorpheniramine Maleate

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Bromhexine

About Bromhexine

Mucolytic (secretolytic)

Mechanism of Action of Bromhexine

Bromhexine hydrochloride acts as a mucokinetic and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and network of fibres in tenacious sputum is broken. It induces thin copious bronchial secretion.

Pharmacokinets of Bromhexine

Absorption: Bromhexine hydrochloride is rapidly absorbed from the gastrointestinal tract and bioavailability is about 20%. Distribution: It is widely distributed to body tissues in a highly protein bound form; Bromhexine crosses the blood brain barrier and small amounts cross the placenta, Metabolism: It undergoes extensive first-pass metabolism in the liver. Excretion: It is excreted primarily in the urine mainly as metabolites.

Onset of Action for Bromhexine

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Duration of Action for Bromhexine

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Half Life of Bromhexine

12hours.

Side Effects of Bromhexine

1 Rhinorrhoea
2 Lacrimations
3.Allergic reactions
4.Gastric irritation.

Contra-indications of Bromhexine

Hypersensitivity to the drug.

Special Precautions while taking Bromhexine

1. Hepatic impairment
2. Renal impairment
3. Gastric and duodenal ulcer
4. Convulsive disorders

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Use with caution

Indications for Bromhexine

1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
3. Bronchitis
4. Pharyngitis
5. Laryngitis
6. Rhinitis
7. Sinusitis
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10.Chronic Pneumonia.

Interactions for Bromhexine

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Typical Dosage for Bromhexine

Oral: 8mg thrice daily.
Children (5 to 10 years): 4mg thrice daily
Children (1 to 5 years): 4mg twice daily.

Schedule of Bromhexine

Storage Requirements for Bromhexine

Store in a cool dry place and protect from light. Keep out of reach of children.

Effects of Missed Dosage of Bromhexine

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Bromhexine

Provide symptomatic treatment and supportive measures.

Home Delivery for Phenylpropanolamine + Chlorpheniramine Maleate + Bromhexine in Your City

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Please be aware that you should take phenylpropanolamine + chlorpheniramine maleate + bromhexine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for phenylpropanolamine + chlorpheniramine maleate + bromhexine before they complete the sale. You can get this information while placing the order for phenylpropanolamine + chlorpheniramine maleate + bromhexine with the pharmacy.

Phenylpropanolamine + Chlorpheniramine Maleate + Bromhexine is a generic medicine name and there are several brands available for it. Some of the brands for phenylpropanolamine + chlorpheniramine maleate + bromhexine might be better known than phenylpropanolamine + chlorpheniramine maleate + bromhexine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have phenylpropanolamine + chlorpheniramine maleate + bromhexine in stock, you can ask for one of the branded alternatives for phenylpropanolamine + chlorpheniramine maleate + bromhexine.