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- Pharmacology For Desloratadine + Ambroxol
Desloratadine + Ambroxol Pharmacology
Desloratadine + Ambroxol
About Desloratadine + AmbroxolN/AMechanism of Action of Desloratadine + AmbroxolN/APharmacokinets of Desloratadine + AmbroxolN/AOnset of Action for Desloratadine + AmbroxolN/ADuration of Action for Desloratadine + AmbroxolN/AHalf Life of Desloratadine + AmbroxolN/ASide Effects of Desloratadine + AmbroxolN/AContra-indications of Desloratadine + AmbroxolN/ASpecial Precautions while taking Desloratadine + AmbroxolN/APregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Desloratadine + Ambroxol1.Respiratory disorders
2.Allergies
Interactions for Desloratadine + AmbroxolN/ATypical Dosage for Desloratadine + Ambroxol1 tab/daySchedule of Desloratadine + AmbroxolN/AStorage Requirements for Desloratadine + AmbroxolN/AEffects of Missed Dosage of Desloratadine + AmbroxolN/AEffects of Overdose of Desloratadine + AmbroxolN/ADesloratadine
About DesloratadineSecond Generation long-acting tricyclic H1 Antagonist, Antihistamine.Mechanism of Action of DesloratadineThis second generation antihistamine has a selective peripheral H1-antagonist action.Desloratadine competes with free histamine for binding at H1-receptors in the GI tract, uterus, large blood vessels, and bronchial smooth muscle. This inhibit the action of histamine, which subsequently leads to temporary relief of the negative symptoms brought by histaminePharmacokinets of DesloratadineAbsorption- Rapidly absorbed after oral administration
Distribution- Widely distributed in the body. 85% bound to the plasma proteins
Metabolism- Metabolized in the liver to its metabolites
Excretion- Excrete through urine (40% as conjugated form) and feces
Onset of Action for DesloratadineN/ADuration of Action for DesloratadineN/AHalf Life of DesloratadineIts plasma half life is 50hrsSide Effects of Desloratadine1. Dizziness
2. Dry mouth
3. Dysmenorrhea
4. Dyspepsia
5. Belching
6. Heartburn
7. Indigestion
8. Stomach discomfort
9. Fatigue
10. Myalgia
11. Difficulty in moving
12. Pharyngitis
13. Fever
14. Hoarseness
15. Runny nose
16. Tender swollen glands in neck
17. Trouble in swallowing
18. Voice changes
19. Somnolence
20. NauseaContra-indications of Desloratadine1. Dizziness
2. Dry mouth
3. Dysmenorrhea
4. Dyspepsia
5. Belching
6. Heartburn
7. Iindigestion
8. Stomach discomfort
9. Fatigue
10. Myalgia
11. Difficulty in moving
12. Pharyngitis
13. Fever
14. Hoarseness
15. Runny nose
16. Tender swollen glands in neck
17. Trouble in swallowing
18. Voice changes
19. Somnolence
20. NauseaSpecial Precautions while taking Desloratadine1. Liver disease
2. Kidney disease
3. Phenylketonuria
4. Any work which require mental alertness such as driving and machine operation
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Desloratadine1. Hay fever
2. Watery eyes
3. Runny nose
4. Itching eyes
5. Sneezing
6. Hives
7. Decongestant
Interactions for DesloratadineN/ATypical Dosage for DesloratadineOral-
Adult (general dose)-
5mg/day
Children (>12yrs)-Same as adult
Schedule of DesloratadineN/AStorage Requirements for DesloratadineStored at room temperature. Protect from light and excessive heat. Keep out of reach of childrenEffects of Missed Dosage of DesloratadineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the doseEffects of Overdose of DesloratadineGive symptomatic and supportive treatmentAmbroxol
About AmbroxolActive N-desmethyl metabolite of bromhexine,systemically active mucolytic agent, Secretomotoric and expectoration improver.Mechanism of Action of AmbroxolAmbroxol hydrochloride acts as an expectoration improver and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and by breaking network of fibres in tenacious sputum . It induces thin copious bronchial secretion and possesses antioxidant properties.Pharmacokinets of AmbroxolN/AOnset of Action for AmbroxolN/ADuration of Action for AmbroxolN/AHalf Life of AmbroxolN/ASide Effects of Ambroxol1. Rhinorrhoea
2. Lacrimations
3. Allergic reactions
4. Gastric irritation.Contra-indications of AmbroxolHypersensitivity to the Ambroxol hydrochloride or Bromhexine.Special Precautions while taking Ambroxol1.Hepatic impairment
2.Renal impairment
3.Gastric and duodenal ulcer
4.Convulsive disorders
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Ambroxol1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
3. Bronchitis
4. Pharyngitis
5. Laryngitis
6. Rhinitis
7. Sinusitis
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10. Chronic Pneumonia.Interactions for AmbroxolN/ATypical Dosage for AmbroxolOral: 15mg to 30mg three times daily.
Children (6 to 12years): 5ml 2 to 3 times daily
Children (2 to 6years): 2.5ml thrice daily. (5ml liquid contains 30mg Ambroxol hydrochloride)
Children up to 2 years: 7.5mg two times daily
Schedule of AmbroxolHStorage Requirements for AmbroxolStore in a cool dry place and protect from light. Keep out of reach of children.Effects of Missed Dosage of AmbroxolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AmbroxolProvide symptomatic treatment and supportive measures.Home Delivery for Desloratadine + Ambroxol in Your City
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Desloratadine + Ambroxol is a generic medicine name and there are several brands available for it. Some of the brands for desloratadine + ambroxol might be better known than desloratadine + ambroxol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have desloratadine + ambroxol in stock, you can ask for one of the branded alternatives for desloratadine + ambroxol.