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- Pharmacology For Cetirizine + Ambroxol
Cetirizine + Ambroxol Pharmacology
Cetirizine + Ambroxol
About Cetirizine + AmbroxolN/AMechanism of Action of Cetirizine + AmbroxolN/APharmacokinets of Cetirizine + AmbroxolN/AOnset of Action for Cetirizine + AmbroxolN/ADuration of Action for Cetirizine + AmbroxolN/AHalf Life of Cetirizine + AmbroxolN/ASide Effects of Cetirizine + AmbroxolN/AContra-indications of Cetirizine + AmbroxolN/ASpecial Precautions while taking Cetirizine + AmbroxolN/APregnancy Related InformationContraindicated; since Cetrizine and Ambroxol are contraindicated in pregnancy; the combination generic are contraindicated in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationContraindicated; since Cetrizine and Ambroxol are contraindicated in breast feeding ;the combination generic are contraindicated in breast feeding mother.Children Related InformationN/AIndications for Cetirizine + AmbroxolIt is a combination of Non sedative antihistamine with Decongestant action, Cetrizine and expectorant Ambroxol.
1.Seasonal and perennial allergic rhinitis
2.Decongestant
Interactions for Cetirizine + AmbroxolN/ATypical Dosage for Cetirizine + AmbroxolAdult: 1 tablet / day.
Each tablet contains Cetrizine hydrochloride 5 mg + Ambroxol hydrochloride 75 mg or
Cetrizine hydrochloride 10 mg + Ambroxol hydrochloride 60 mg .
Syrup- Cetrizine hydrochloride 2.5 mg + Ambroxol hydrochloride 30 mg / 5ml
Schedule of Cetirizine + AmbroxolN/AStorage Requirements for Cetirizine + AmbroxolN/AEffects of Missed Dosage of Cetirizine + AmbroxolN/AEffects of Overdose of Cetirizine + AmbroxolN/ACetirizine
About CetirizineSecond Generation H1 Antagonist, Metabolite of hydroxyzine, Antihistamine.Mechanism of Action of CetirizineThis drug is a selective peripheral H1 receptor antagonist. Thus it inhibits the allergic symptoms produced by histamines like cold, rhinorrhea, sneezing, urticaria etc. The drug has some mast cell stabilizing properties. It also inhibit eotaxin-induced eosinophil TEM through both dermal and lung micro vascular endothelial cells. So inhibit eosinophil chemotaxis and also inflammation caused by it.Pharmacokinets of CetirizineAbsorption- Well absorbed after oral administration
Distribution-Widely distributed in the body. 93% bound to the plasma proteins. It enters to the CNS in small amounts.
Metabolism-Metabolized in the liver to its metabolites by oxidative O-dealkylation
Excretion- Excreted through urine (50% as unchanged form) and a small amount through feces
Onset of Action for Cetirizine10-30 minDuration of Action for Cetirizine12-24hrsHalf Life of CetirizineIts plasma half life is 8.3 hrsSide Effects of Cetirizine1. Somnolence.
2. Fatigue
3. Malaise
4. Headache
5. Dry mouth
6. CNS stimulation in children
7. Dizziness
8. Tinnitus
9. Incordination
10. Blurred vision
12. Diplopia
13. Euphoria
14. Nervousness
15. Drowsiness
16. Excessive tiredness
17. Vomiting
18. Diarrhea
19. Sore throat
20. Stomach pain
Contra-indications of CetirizineHypersensitivity to the drug or hydroxyzine.Special Precautions while taking Cetirizine1. Renal impairment.
2. Hepatic dysfunction.
3. Haemodialysis.
4. Any work which require mental alertness like driving or machine operation.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Cetirizine1. Sneezing
2. Rhinorrhoea
3. Postnasal discharge.
4. Common coughs
5. Colds.
6. Chronic urticaria
7. Dermatitis
8. Pruritic skin disorders
9. Hay fever
10. Angioedema
Interactions for CetirizineAlcohol: Avoid excessive alcohol consumption.Typical Dosage for CetirizineOral-
Adult - 10 mg daily, single dose
Children (6-12 years) -5 mg daily.
Schedule of CetirizineN/AStorage Requirements for CetirizineStore in cool, dry, dark placeEffects of Missed Dosage of CetirizineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of CetirizineGive symptomatic and supportive treatment.Ambroxol
About AmbroxolActive N-desmethyl metabolite of bromhexine,systemically active mucolytic agent, Secretomotoric and expectoration improver.Mechanism of Action of AmbroxolAmbroxol hydrochloride acts as an expectoration improver and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and by breaking network of fibres in tenacious sputum . It induces thin copious bronchial secretion and possesses antioxidant properties.Pharmacokinets of AmbroxolN/AOnset of Action for AmbroxolN/ADuration of Action for AmbroxolN/AHalf Life of AmbroxolN/ASide Effects of Ambroxol1. Rhinorrhoea
2. Lacrimations
3. Allergic reactions
4. Gastric irritation.Contra-indications of AmbroxolHypersensitivity to the Ambroxol hydrochloride or Bromhexine.Special Precautions while taking Ambroxol1.Hepatic impairment
2.Renal impairment
3.Gastric and duodenal ulcer
4.Convulsive disorders
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Ambroxol1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
3. Bronchitis
4. Pharyngitis
5. Laryngitis
6. Rhinitis
7. Sinusitis
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10. Chronic Pneumonia.Interactions for AmbroxolN/ATypical Dosage for AmbroxolOral: 15mg to 30mg three times daily.
Children (6 to 12years): 5ml 2 to 3 times daily
Children (2 to 6years): 2.5ml thrice daily. (5ml liquid contains 30mg Ambroxol hydrochloride)
Children up to 2 years: 7.5mg two times daily
Schedule of AmbroxolHStorage Requirements for AmbroxolStore in a cool dry place and protect from light. Keep out of reach of children.Effects of Missed Dosage of AmbroxolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AmbroxolProvide symptomatic treatment and supportive measures.Home Delivery for Cetirizine + Ambroxol in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cetirizine + ambroxol and other medicines and health products. Home delivery services for cetirizine + ambroxol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take cetirizine + ambroxol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cetirizine + ambroxol before they complete the sale. You can get this information while placing the order for cetirizine + ambroxol with the pharmacy.
Cetirizine + Ambroxol is a generic medicine name and there are several brands available for it. Some of the brands for cetirizine + ambroxol might be better known than cetirizine + ambroxol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cetirizine + ambroxol in stock, you can ask for one of the branded alternatives for cetirizine + ambroxol.