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- Pharmacology For Pseudoephedrine + Chlorpheniramine Maleate + Caffeine
Pseudoephedrine + Chlorpheniramine Maleate + Caffeine Pharmacology
Pseudoephedrine + Chlorpheniramine Maleate + Caffeine
About Pseudoephedrine + Chlorpheniramine Maleate + CaffeineN/AMechanism of Action of Pseudoephedrine + Chlorpheniramine Maleate + CaffeineN/APharmacokinets of Pseudoephedrine + Chlorpheniramine Maleate + CaffeineN/AOnset of Action for Pseudoephedrine + Chlorpheniramine Maleate + CaffeineN/ADuration of Action for Pseudoephedrine + Chlorpheniramine Maleate + CaffeineN/AHalf Life of Pseudoephedrine + Chlorpheniramine Maleate + CaffeineN/ASide Effects of Pseudoephedrine + Chlorpheniramine Maleate + CaffeineN/AContra-indications of Pseudoephedrine + Chlorpheniramine Maleate + CaffeineN/ASpecial Precautions while taking Pseudoephedrine + Chlorpheniramine Maleate + CaffeineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Pseudoephedrine + Chlorpheniramine Maleate + CaffeineN/AInteractions for Pseudoephedrine + Chlorpheniramine Maleate + CaffeineN/ATypical Dosage for Pseudoephedrine + Chlorpheniramine Maleate + CaffeineN/ASchedule of Pseudoephedrine + Chlorpheniramine Maleate + CaffeineN/AStorage Requirements for Pseudoephedrine + Chlorpheniramine Maleate + CaffeineN/AEffects of Missed Dosage of Pseudoephedrine + Chlorpheniramine Maleate + CaffeineN/AEffects of Overdose of Pseudoephedrine + Chlorpheniramine Maleate + CaffeineN/APseudoephedrine
About PseudoephedrineAlpha/Beta Adrenergic Agonist, a phenethylamine derivative, A nasal decongestant.Mechanism of Action of PseudoephedrineIt is a nasal decongestant with alpha-2 agonistic action. It produces local vasoconstriction, reduces blood flow, and causes shrinkage of mucosa which provides relief of nasal congestion. It reduces oedema of the nasal mucosa, thus improving ventilation, drainage and nasal stuffiness.Pharmacokinets of PseudoephedrineAbsorption: Well absorbed orally, Distribution: Widely distributed throughout the body, Metabolism: Partially metabolized in liver by N-demethylation, Excretion: Excreted through urine mainly as unchanged drug and also as metabolites.Onset of Action for Pseudoephedrine30 minutesDuration of Action for Pseudoephedrine4 to 8 hoursHalf Life of PseudoephedrineN/ASide Effects of Pseudoephedrine1. Rise in blood pressure
2. Tachycardia
3. Arrhythmias
4. CNS stimulation
5. Restlessness
6. Insomnia
7. Anxiety
8. Tremors
9. Skin rashes
10. Urinary retention
11. Respiratory difficulties
Contra-indications of Pseudoephedrine1. Hypersensitivity to the drug
2. Severe hypertension
3. Coronary artery disease
4. Patients taking monoamine oxidase inhibitors (MAOIs) or who have taken MAOIs within the previous 14 days
5. Extended release preparations are contraindicated in children below 12 yearsSpecial Precautions while taking Pseudoephedrine1. Hypertension
2. Cardiac diseases
3. Diabetes
4. Glaucoma
5. Prostatic hyperplasia
6. Hyperthyroidism
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Pseudoephedrine1. Nasal and Eustachian tube congestion
2.Upper respiratory tract congestion
3.Adjunctive therapy in symptomatic relief of common cold, allergic rhinitis, blocked Eustachian tube, and upper respiratory tract infectionsInteractions for PseudoephedrineN/ATypical Dosage for PseudoephedrineOral:
Adults and children over 12 years: 60mg 3 to 4 times daily
Maximum dose: 240mg/day
Children (age 6 to 12): 30mg 3 to 4 times daily
Maximum dose: 120mg/day
Children (age 2 to 6): 15mg 3 to 4 times daily
Maximum dose: 60mg/day or 4mg/kg.
Schedule of PseudoephedrineN/AStorage Requirements for PseudoephedrineStore at controlled room temperature at a range of 15 to 30 degree C. Keep out of reach of childrenEffects of Missed Dosage of PseudoephedrineTake the missed dose as soon as noticed and if it is the time for next dose
Effects of Overdose of PseudoephedrineContinue the regular schedule. Do not double the dose.
Over dosage and poisoning: Provide symptomatic treatment and supportive measures. Perform emesis and gastric lavage within 4 hours of ingestion. If renal function is adequate forced diuresis will increase elimination of the drug. (Do not force diuresis in severe poisoning). Monitor and assist vital signs, cardiac state and electrolyte balance. Treat cardiac toxicity with Propranolol or other effective drugs. Treat seizures with Diazepam (I.V.) and give dilute Potassium chloride solution for hypokalaemia.
Chlorpheniramine Maleate
About Chlorpheniramine MaleateN/AMechanism of Action of Chlorpheniramine MaleateN/APharmacokinets of Chlorpheniramine MaleateN/AOnset of Action for Chlorpheniramine MaleateN/ADuration of Action for Chlorpheniramine MaleateN/AHalf Life of Chlorpheniramine MaleateN/ASide Effects of Chlorpheniramine MaleateN/AContra-indications of Chlorpheniramine MaleateFirst Generation alkylamine H1 Antagonist, Antihistamine.Special Precautions while taking Chlorpheniramine MaleateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Chlorpheniramine MaleateN/AInteractions for Chlorpheniramine MaleateN/ATypical Dosage for Chlorpheniramine MaleateN/ASchedule of Chlorpheniramine MaleateN/AStorage Requirements for Chlorpheniramine MaleateN/AEffects of Missed Dosage of Chlorpheniramine MaleateN/AEffects of Overdose of Chlorpheniramine MaleateN/ACaffeine
About CaffeineXanthine alkaloid, Central stimulant and metabolic stimulant.Mechanism of Action of CaffeineBecause caffeine is both water-soluble and lipid-soluble, it readily crosses the blood?brain barrier .Caffeine stimulates medullary, vagal, vasomotor, and respiratory centers, promoting bradycardia, vasoconstriction, and increased respiratory rate. Xanthines such as caffeine act as antagonists at adenosine-receptors within the plasma membrane of virtually every cell. As adenosine acts as an autocoid, inhibiting the release of neurotransmitters from presynaptic sites but augmenting the actions of norepinephrine or angiotensin, antagonism of adenosine receptors promotes neurotransmitter release. This explains the stimulatory effects of caffeine. Blockade of the adenosine A1 receptor in the heart leads to the accelerated, pronounced "pounding" of the heart upon caffeine intake.Pharmacokinets of Caffeine1.Absorption:Readily absorbed after oral or parenteral administration, C max is 5 to 25 mcg/mL; T max is 15 to 120 min.
2.Distribution:Widely distributed,Protein binding Low (25 to 36%).
3.Metabolism:Hepatic cytochrome P450 1A2
4.Elimination: Renal;In young infants, the elimination of caffeine is much slower than that in adults due to immature hepatic and/or renal function.
Onset of Action for CaffeineN/ADuration of Action for CaffeineN/AHalf Life of Caffeine3 to 7 hours in adults, 65 to 130 hours in neonatesSide Effects of Caffeine1.Insomnia
2.Nervousness or anxiety
3.Irritability
4.Nausea
5.Headache
Contra-indications of Caffeine1.Hyper sensitivity
2.Caffeine and sodium benzoate solution in pediatrics.
Special Precautions while taking Caffeine1.Heart disease
2.Kidney disease
3.Liver disease
4.Stomach problems (e.g., peptic ulcers, necrotizing enterocolitis)
5.Seizures.
Pregnancy Related InformationUse with cautionOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationNot recommended uder 12years of ageIndications for Caffeine1.Orthostatic hypotension
2.Short term treatment of apnea of prematurity in infants
3.Fatigue and drowsiness
4.Analgesia
5.Respiratory depression.
Interactions for Caffeine1.Aspirin, clozapine, theophylline :Plasma levels of these agents may be elevated by caffeine, increasing their pharmacologic effects and adverse reactions.
2.Cimetidine, disulfiram, fluoroquinolones, mexiletine, oral contraceptives :May increase caffeine levels, enhancing the effects.
3.Lithium :Plasma levels may be reduced by caffeine, decreasing the pharmacologic effect.
4.Phenytoin, smoking :May decrease caffeine levels.
Typical Dosage for Caffeine1.Fatigue/Drowsiness :Oral:100 to 200 mg every 3 to 4 h as needed.
2.Apnea of Prematurity
Preterm infants Loading dose: (caffeine citrate) IV 20 mg/kg (1?mL/kg) over 30 min once.
Maintenance dose: (caffeine citrate) IV (over 10?min) or PO 5 mg/kg (0.25 mL/kg) every 24?h.
Schedule of CaffeineN/AStorage Requirements for CaffeineStore caffeine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light.
Effects of Missed Dosage of CaffeineN/AEffects of Overdose of Caffeine1.Get immediate medical attention
2.Symptoms of overdose may include agitation; anxiety; confusion; frequent urination; irregular or fast heartbeat; muscle twitching; ringing in the ears; seizures; stomach pain; trouble sleeping.
Home Delivery for Pseudoephedrine + Chlorpheniramine Maleate + Caffeine in Your City
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