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- Pharmacology For Phenylpropanolamine + Diphenylpyraline
Phenylpropanolamine + Diphenylpyraline Pharmacology
Phenylpropanolamine + Diphenylpyraline
About Phenylpropanolamine + DiphenylpyralineN/AMechanism of Action of Phenylpropanolamine + DiphenylpyralineN/APharmacokinets of Phenylpropanolamine + DiphenylpyralineN/AOnset of Action for Phenylpropanolamine + DiphenylpyralineN/ADuration of Action for Phenylpropanolamine + DiphenylpyralineN/AHalf Life of Phenylpropanolamine + DiphenylpyralineN/ASide Effects of Phenylpropanolamine + DiphenylpyralineN/AContra-indications of Phenylpropanolamine + DiphenylpyralineN/ASpecial Precautions while taking Phenylpropanolamine + DiphenylpyralineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Phenylpropanolamine + DiphenylpyralineN/AInteractions for Phenylpropanolamine + DiphenylpyralineN/ATypical Dosage for Phenylpropanolamine + DiphenylpyralineN/ASchedule of Phenylpropanolamine + DiphenylpyralineN/AStorage Requirements for Phenylpropanolamine + DiphenylpyralineN/AEffects of Missed Dosage of Phenylpropanolamine + DiphenylpyralineN/AEffects of Overdose of Phenylpropanolamine + DiphenylpyralineN/APhenylpropanolamine
About PhenylpropanolamineAlfa-and Beta-adrenergic agonist, Phenethylamine derivative, a stimulant, decongestant,anorectic.Mechanism of Action of PhenylpropanolamineIt is a mixed acting sympathomimetic amine with predominant alpha adrenergic agonistic action. It exerts nasal decongestant action by acting through alpha adrenergic receptors in the respiratory tract mucosa; and produces vasoconstriction. It temporarily reduces the swelling associated with inflammation of nasal mucosa.
Phenylpropanolamine also suppresses the appetite control center in the hypothalamus
Pharmacokinets of PhenylpropanolamineAbsorption: Well absorbed orally, Metabolism: Metabolized in to an active metabolite in liver, Excretion: Excreted mainly through urine.Onset of Action for Phenylpropanolamine15 to 30 minutesDuration of Action for Phenylpropanolamine3 hoursHalf Life of PhenylpropanolamineN/ASide Effects of Phenylpropanolamine1. Hypertension
2. Stroke
3. Arrhythmias
4. Renal failure
5. Rhabdomyolysis
6. Psychotic disturbances
7. Hallucinations
8. SeizuresContra-indications of Phenylpropanolamine1. Hypersensitivity to Phenylpropanolamine or other sympathomimetics
2. Coronary artery disease
3. Hypertension
4. Arteriosclerosis
5. Depression
6. Angle-closure glaucoma
7. Diabetes
8. Renal impairment
9. Hyperthyroidism
10. During or within 14 days of use of MAO inhibitors
11. Use as an anorexiant for children less than 12 years of age
12. Sustained-release forms during lactation and in children less than 12 years of age
Special Precautions while taking Phenylpropanolamine1. Cardiovascular disorders
2. Mild Hypertension
3. Prostatic hypertrophy
4. Psychosis or other psychiatric disorders (Phenylpropanolamine may precipitate psychiatric disorders)
5. Not drinking large amounts of caffeine-containing beverages, such as coffee, tea, or colas
6. Do not engage in driving, using machines, or doing anything else that requires mental alertness while taking medication
7. Inform the physician if cold symptoms do not improve within 7 days or if fever is present
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Phenylpropanolamine1. Nasal congestion
Interactions for PhenylpropanolamineN/ATypical Dosage for PhenylpropanolamineOral:
Adults:
As decongestant: 25mg every four hours or 50mg every 8 hours daily. Not to exceed 150mg/day
Anorexiant: 25mg thrice daily; 30minutes before meals.
Extended release tablets or capsules:As decongestant: 75mg twice daily
Anorexiant: 75mg once daily in the morning.
As decongestant:
Children (6 to 12 years): 12.5mg up to every four hours. Not to exceed 75mg/day
Children (2 to 6years): 6.25mg up to every four hours. Not to exceed 37.5mg/day
Schedule of PhenylpropanolamineHStorage Requirements for PhenylpropanolamineStore at controlled room temperature at range of 15 to 30 degree C.; in a well closed container. Protect from light.Effects of Missed Dosage of PhenylpropanolamineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of PhenylpropanolamineProvide symptomatic treatment and supportive measures.Remove drug from the body by induced emesis or gastric lavage. Barbiturate sedatives are sometimes used to control excessive CNS stimulation. Monitor Cardiovascular and respiratory functions. Administer intravenous fluids to control hypotension. Correct hypertension with Intravenous phentolamine or nitrates. Perform forced diuresis by acidification of urine.
Diphenylpyraline
About DiphenylpyralineFirst Generation H1 Antagonist ,Ethanolamine derivative,piperidine derivative, Antihistamine.Mechanism of Action of DiphenylpyralineDiphenylpyraline exerts its action by acting as an H1 receptor antagonist. It antagonizes most of the pharmacological actions of Histamine and reduces allergic symptoms. It also has anticholinergic properties and reduces secretions.Pharmacokinets of DiphenylpyralineAbsorption: Well absorbed orally, Distribution: Widely distributed in a protein bound form, Metabolism: It is metabolized in the liver.
Onset of Action for DiphenylpyralineN/ADuration of Action for DiphenylpyralineN/AHalf Life of DiphenylpyralineN/ASide Effects of Diphenylpyraline1.Sedation
2.Inability to concentrate
3.Diminished alertness
4.Motor incordination
5.Fatigue
6.Insomnia
7.Somnolence
8.Dry mouth
9.Urinery hesitancy
10.Altered bowel movement.
Contra-indications of Diphenylpyraline1.Cardiac and blood vessel diseases
2.Disorders of blood
3.Hypertrophy of prostate
4.Blockade of urinary tract or difficulty in urination
5.Epilepsy
6.Jaundice
7.Glaucoma
8.Hepatic impairment
9.Reye`s syndrome.
Special Precautions while taking Diphenylpyraline1.Driving or any work requiring mental alertnessPregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Diphenylpyraline1. As an ingredient in cough mixturesInteractions for DiphenylpyralineN/ATypical Dosage for DiphenylpyralineAs directed by the PhysicianSchedule of DiphenylpyralineGStorage Requirements for DiphenylpyralineStore in a well closed container below 25 degree C.Effects of Missed Dosage of DiphenylpyralineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DiphenylpyralineProvide symptomatic treatment and supportive measures.Home Delivery for Phenylpropanolamine + Diphenylpyraline in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for phenylpropanolamine + diphenylpyraline and other medicines and health products. Home delivery services for phenylpropanolamine + diphenylpyraline may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take phenylpropanolamine + diphenylpyraline only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for phenylpropanolamine + diphenylpyraline before they complete the sale. You can get this information while placing the order for phenylpropanolamine + diphenylpyraline with the pharmacy.
Phenylpropanolamine + Diphenylpyraline is a generic medicine name and there are several brands available for it. Some of the brands for phenylpropanolamine + diphenylpyraline might be better known than phenylpropanolamine + diphenylpyraline itself. If the pharmacy that's willing to deliver medicines to your home doesn't have phenylpropanolamine + diphenylpyraline in stock, you can ask for one of the branded alternatives for phenylpropanolamine + diphenylpyraline.