Betahistine Pharmacology

Betahistine

About Betahistine

H1 selective histamine analogue, diamine oxidase inhibitor, anti vertigo and in Meniere?s syndrome.

Mechanism of Action of Betahistine

Betahistine is a histamine substitute. It produces vasodilatation and improves blood flow to the labyrinth and brain stem. There by it reduces the frequency of episodes of vertigo in patient with Meniere`s syndrome.
It works directly on histamine receptors. These receptors are found in blood vessel walls including those in the ear. Activation of these receptors will results in the widening of blood vessels. This improves circulation reducing the pressure in the ear. Its main use is in treating Meniere`s disease. It helps in relieving the inner ear pressure and by reducing the frequency and severity of nausea and vertigo attacks. It also reduces tinnitus thus helping to restore normal hearing.
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Pharmacokinets of Betahistine

Absorption: It is very rapidly absorbed after oral administration. Metabolism: Betahistine is rapidly metabolised in the liver to 2-pyridylacetic acid. Excretion: Excreted mainly in urine

Onset of Action for Betahistine

Within 1 hr.

Duration of Action for Betahistine

6-12 hours.

Half Life of Betahistine

3.5 hours

Side Effects of Betahistine

1.Headache
2.Rashes
3.Pruritis
4.Gastrointestinal disturbances
5.Nausea
6.Urticaria
7.Dizziness
8.Insomnia
9.Dyspepsia

Contra-indications of Betahistine

1.Hypersensitivity to Betahistine
2.Pheochromocytoma

Special Precautions while taking Betahistine

1.Asthma
2.Ulcer
3.Patient receiving antihistamines

Pregnancy Related Information

Use with caution.

Old Age Related Information

Use with caution.

Breast Feeding Related Information

Use with caution.

Children Related Information

Contraindicated

Indications for Betahistine

1.Meniere`s syndrome
2.Vertigo

Interactions for Betahistine

Antihistaminics : Betahistine dihydrochloride antagonises the effects of antihistaminics

Typical Dosage for Betahistine

Adult: 8 mg 3 times daily with meals. Dose can be increased if needed to 48 mg / day.
Children: not recommended

Schedule of Betahistine

Storage Requirements for Betahistine

Store at room temperature. Protect from light and moisture.

Effects of Missed Dosage of Betahistine

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Betahistine

Give supportive measures and symptomatic treatment.

Home Delivery for Betahistine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including betahistine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for betahistine and other medicines and health products. Home delivery services for betahistine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take betahistine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for betahistine before they complete the sale. You can get this information while placing the order for betahistine with the pharmacy.

Betahistine is a generic medicine name and there are several brands available for it. Some of the brands for betahistine might be better known than betahistine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have betahistine in stock, you can ask for one of the branded alternatives for betahistine.