Meclizine + Caffeine Pharmacology

Meclizine + Caffeine

About Meclizine + Caffeine
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Mechanism of Action of Meclizine + Caffeine
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Pharmacokinets of Meclizine + Caffeine
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Onset of Action for Meclizine + Caffeine
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Duration of Action for Meclizine + Caffeine
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Half Life of Meclizine + Caffeine
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Side Effects of Meclizine + Caffeine
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Contra-indications of Meclizine + Caffeine
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Special Precautions while taking Meclizine + Caffeine
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Meclizine + Caffeine
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Interactions for Meclizine + Caffeine
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Typical Dosage for Meclizine + Caffeine
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Schedule of Meclizine + Caffeine
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Storage Requirements for Meclizine + Caffeine
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Effects of Missed Dosage of Meclizine + Caffeine
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Effects of Overdose of Meclizine + Caffeine
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Meclizine

About Meclizine
First Generation H1 Antagonist, Piperazine derivative, Antihistamine, antiemetic, antinauseant.
Mechanism of Action of Meclizine
Meclizine produces Antiemetic action by its central action on Chemoreceptor trigger zone (CTZ). It decreases the sensitivity of Labyrinth apparatus which transmit stimuli to the CTZ and stimulates the vomiting center.
Meclizine produces antivertigo action by decreasing the excitability of middle ear labyrinth. It blocks the conduction in the middle ear vestibular path ways.
Meclizine is a potent H1 receptor antihistaminic agent. It has anticholinergic activity also

Pharmacokinets of Meclizine
Absorption: It is well absorbed after oral administration. Distribution: It is very widely distributed in the body. Metabolism: It is metabolised in the liver. Excretion: Drug is excreted in faeces and also in urine.
Onset of Action for Meclizine
1 hour
Duration of Action for Meclizine
8 - 24 hours
Half Life of Meclizine
6 hours
Side Effects of Meclizine
1.Drowsiness
2.Dry mouth
3.Restlessness
4.Urine retention
5.Blurred vision
6.Constipation
7.Abdominal discomfort
Contra-indications of Meclizine
1.Hypersensitivity to Meclizine
Special Precautions while taking Meclizine
1.Glaucoma
2.Asthma
3.Prostate hypertrophy
4.Alcoholics
5.Patient should be cautioned about driving vehicle or operating machines

Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated.
Children Related Information
Use with caution
CHILDREN below12 years: contraindicated
NEONATES: contraindicated
Indications for Meclizine
1.Dizziness
2.Motion sickness
3.Vertigo
Interactions for Meclizine
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Typical Dosage for Meclizine
Adult:
Dizziness: 25 - 100 mg in 3 divided doses
Motion sickness: 25 - 50 mg to be taken 1 hour before beginning the travel and repeat the dose if necessary depending on the duration of journey
Children above 12 years:
Dizziness: 25 - 100 mg in 3 divided doses
Motion sickness: 25 - 50 mg to be taken 1 hour before beginning the travel and repeat the dose if necessary depending on the duration of journey

Schedule of Meclizine
G
Storage Requirements for Meclizine
Store the drug at room temperature in a tightly closed container. Protect from heat and light.
Effects of Missed Dosage of Meclizine
Take the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Meclizine
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage. Hypotension can be treated with vasopressors and seizure with Diazepam or Phenytoin.

Caffeine

About Caffeine
Xanthine alkaloid, Central stimulant and metabolic stimulant.
Mechanism of Action of Caffeine
Because caffeine is both water-soluble and lipid-soluble, it readily crosses the blood?brain barrier .Caffeine stimulates medullary, vagal, vasomotor, and respiratory centers, promoting bradycardia, vasoconstriction, and increased respiratory rate. Xanthines such as caffeine act as antagonists at adenosine-receptors within the plasma membrane of virtually every cell. As adenosine acts as an autocoid, inhibiting the release of neurotransmitters from presynaptic sites but augmenting the actions of norepinephrine or angiotensin, antagonism of adenosine receptors promotes neurotransmitter release. This explains the stimulatory effects of caffeine. Blockade of the adenosine A1 receptor in the heart leads to the accelerated, pronounced "pounding" of the heart upon caffeine intake.
Pharmacokinets of Caffeine
1.Absorption:Readily absorbed after oral or parenteral administration, C max is 5 to 25 mcg/mL; T max is 15 to 120 min.
2.Distribution:Widely distributed,Protein binding Low (25 to 36%).
3.Metabolism:Hepatic cytochrome P450 1A2
4.Elimination: Renal;In young infants, the elimination of caffeine is much slower than that in adults due to immature hepatic and/or renal function.
Onset of Action for Caffeine
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Duration of Action for Caffeine
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Half Life of Caffeine
3 to 7 hours in adults, 65 to 130 hours in neonates
Side Effects of Caffeine
1.Insomnia
2.Nervousness or anxiety
3.Irritability
4.Nausea
5.Headache
Contra-indications of Caffeine
1.Hyper sensitivity
2.Caffeine and sodium benzoate solution in pediatrics.
Special Precautions while taking Caffeine
1.Heart disease
2.Kidney disease
3.Liver disease
4.Stomach problems (e.g., peptic ulcers, necrotizing enterocolitis)
5.Seizures.
Pregnancy Related Information
Use with caution
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
Not recommended uder 12years of age
Indications for Caffeine
1.Orthostatic hypotension
2.Short term treatment of apnea of prematurity in infants
3.Fatigue and drowsiness
4.Analgesia
5.Respiratory depression.
Interactions for Caffeine
1.Aspirin, clozapine, theophylline :Plasma levels of these agents may be elevated by caffeine, increasing their pharmacologic effects and adverse reactions.
2.Cimetidine, disulfiram, fluoroquinolones, mexiletine, oral contraceptives :May increase caffeine levels, enhancing the effects.
3.Lithium :Plasma levels may be reduced by caffeine, decreasing the pharmacologic effect.
4.Phenytoin, smoking :May decrease caffeine levels.
Typical Dosage for Caffeine
1.Fatigue/Drowsiness :Oral:100 to 200 mg every 3 to 4 h as needed.
2.Apnea of Prematurity
Preterm infants Loading dose: (caffeine citrate) IV 20 mg/kg (1?mL/kg) over 30 min once.
Maintenance dose: (caffeine citrate) IV (over 10?min) or PO 5 mg/kg (0.25 mL/kg) every 24?h.

Schedule of Caffeine
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Storage Requirements for Caffeine
Store caffeine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light.

Effects of Missed Dosage of Caffeine
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Effects of Overdose of Caffeine
1.Get immediate medical attention
2.Symptoms of overdose may include agitation; anxiety; confusion; frequent urination; irregular or fast heartbeat; muscle twitching; ringing in the ears; seizures; stomach pain; trouble sleeping.

Home Delivery for Meclizine + Caffeine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including meclizine + caffeine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for meclizine + caffeine and other medicines and health products. Home delivery services for meclizine + caffeine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take meclizine + caffeine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for meclizine + caffeine before they complete the sale. You can get this information while placing the order for meclizine + caffeine with the pharmacy.

Meclizine + Caffeine is a generic medicine name and there are several brands available for it. Some of the brands for meclizine + caffeine might be better known than meclizine + caffeine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have meclizine + caffeine in stock, you can ask for one of the branded alternatives for meclizine + caffeine.