Dobutamine Pharmacology

Dobutamine

About Dobutamine
Adrenergic Agonist Agent, Cardiac stimulant in CHF ,Directly acting inotropic agent.
Mechanism of Action of Dobutamine
Dobutamine exerts its pharmacological action by selectively stimulating beta-1 adrenergic receptors. It is a positive inotropic drug and increases stroke volume and cardiac out put without significant change in heart rate, peripheral resistance and BP. It improves coronary blood flow and myocardial oxygen consumption.
Pharmacokinets of Dobutamine
Absorption: It administered intravenously.
Distribution: Widely distributed throughout the body.
Metabolism: Metabolized in liver by conjugation in to inactive metabolites.
Excretion: Excreted mainly through urine as metabolites. A small portion is excreted through faeces.
Onset of Action for Dobutamine
1 to 2 minutes
Duration of Action for Dobutamine
< 5 minutes
Half Life of Dobutamine
N/A
Side Effects of Dobutamine
1. Hypertension
2. Increased heart rate
3. Premature ventricular contraction
4. Chest pain
5. Palpitation
6. Hypotension
7. Episodes of asthma
8. Hypersensitivity reactions
9. Nausea
10. Vomiting
11. Headache

Contra-indications of Dobutamine
1. Hypersensitivity to the drug
2. Hypertrophic subaortic stenosis

Special Precautions while taking Dobutamine
1. Hypertension
2. Atrial fibrillation
3. Monitor ECG and blood pressure during therapy
4. Hypovolemia should be corrected before therapy using suitable volume expanders
5. Drug may precipitate an exaggerated pressor response
6. Do not mix with sodium bicarbonate
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Dobutamine
1. Acute myocardial infarction
2. Acute heart failure
3. Cardiogenic Shock
4. Septic Shock
5. During cardiac surgery
6. Chronic CHF
Interactions for Dobutamine
Bretylium: Potentiates its action resulting in arrhythmias.
Halogenated hydrocarbon anaesthetics: Risk of serious arrhythmias.
Oxytoxic drugs: May cause persistent hypertension.
TCAs: Use with caution since efficacy of vasopressor enhanced.
Phentolamine & Prazosin: Antagonistic action.
Nitroprusside: Additive effect.
Typical Dosage for Dobutamine
2 to 20mcg/kg/minute as I.V. infusion. Dosage adjustment is based on patient`s response.
Maximum dose: 40mcg/kg/minute.

Schedule of Dobutamine
N/A
Storage Requirements for Dobutamine
Store at room temperature in a range of 15 to 30 degree C. Protect from moisture.
Effects of Missed Dosage of Dobutamine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Dobutamine
Give supportive measures and symptomatic treatment.

Home Delivery for Dobutamine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including dobutamine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for dobutamine and other medicines and health products. Home delivery services for dobutamine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take dobutamine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dobutamine before they complete the sale. You can get this information while placing the order for dobutamine with the pharmacy.

Dobutamine is a generic medicine name and there are several brands available for it. Some of the brands for dobutamine might be better known than dobutamine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dobutamine in stock, you can ask for one of the branded alternatives for dobutamine.