Piracetam Pharmacology

Piracetam

About Piracetam
Pyrrolidone derivative, a cyclic derivative of GABA, Nootropic,in cerebrovascular insults and insufficiency.
Mechanism of Action of Piracetam
Piracetam is a cyclic GABA derivative. It facilitates the movement of information between the brain`s 2 hemispheres via corpus callosum and improves the function of Acetylcholine via muscarinic receptors which are implicated in memory process. Piracetam is also called as Nootropics or cognition enhancer.
Piracetam improves the production of adenosine triphosphate (ATP) which is the energy storage and energy generating molecules within our cells. Piracetam increases the blood flow to the brain and promote cerebral metabolism. It increases brain`s use of glucose and oxygen. It also enhances protein synthesis in the brain.
Piracetam enhances the excitatory neurotransmitter NMDA glutamate receptor which is involved in learning and memory process.
Piracetam modulates calcium and potassium ion channels.
Pharmacokinets of Piracetam
Absorption: It is well absorbed after oral administration.
Excretion: It is excreted mainly through urine.
Onset of Action for Piracetam
30 - 60 minutes
Duration of Action for Piracetam
1 day
Half Life of Piracetam
4 - 5 hours
Side Effects of Piracetam
1. Nausea
2. Epigastric distress
3. Skin rash
4. Hyperkinesias
5. Nervousness
6. Depression
7. Diarrhoea
8. Sleep disturbances
9. Dizziness
10. Excitement
11. Insomnia
12. Somnolence
13. Weight gain
Contra-indications of Piracetam
N/A
Special Precautions while taking Piracetam
1. Hepatic impairment
2. Renal impairment
3. Cardiac impairment
4. Slowly withdraw the drug with caution
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
NEONATES : Contraindicated
Indications for Piracetam
1. Mental retardation and Dyslexia in children
2. Senile dementia and confusional states of old age
3. Cerebrovascular accidents
4. To reduce impairment of consciousness following brain surgery
Interactions for Piracetam
Oral anticoagulants: Increased prothrombin time.
Typical Dosage for Piracetam
Adults: Ischemic stroke: 12gm I.V./20 minutes, followed by 12gm I.V./day for 4 weeks or orally.
Post-stroke complications (aphasia/hemiplegia): 4.8gm/day for 8 weeks.
Age associated problems (memory lapses, vertigo, concentration gap): 2.4-4.8 gm/day for 12 weeks
Learning difficulties: 3 gm/day in 3 divided doses for 1 school year.
Children: 50 mg/kg body weight in 3 separate doses. Once the desired result has been obtained reduce the initial dose by half upto 6-8 weeks.
Schedule of Piracetam
H
Storage Requirements for Piracetam
Store below 25 degree C in tightly closed container moisture. Protect from moisture. Keep out of the reach of children.
Effects of Missed Dosage of Piracetam
Take the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose and take that dose. Do not double the dose. Continue the regular schedule.
Effects of Overdose of Piracetam
Give supportive measures and symptomatic treatment. Drug can be removed from the body by forced diuresis. In renal insufficiency drug can be removed by dialysis.

Home Delivery for Piracetam in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including piracetam.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for piracetam and other medicines and health products. Home delivery services for piracetam may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take piracetam only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for piracetam before they complete the sale. You can get this information while placing the order for piracetam with the pharmacy.

Piracetam is a generic medicine name and there are several brands available for it. Some of the brands for piracetam might be better known than piracetam itself. If the pharmacy that's willing to deliver medicines to your home doesn't have piracetam in stock, you can ask for one of the branded alternatives for piracetam.