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- Pharmacology For Flupenthixol + Melitracen
Flupenthixol + Melitracen Pharmacology
Flupenthixol + Melitracen
About Flupenthixol + MelitracenN/AMechanism of Action of Flupenthixol + MelitracenN/APharmacokinets of Flupenthixol + MelitracenN/AOnset of Action for Flupenthixol + MelitracenN/ADuration of Action for Flupenthixol + MelitracenN/AHalf Life of Flupenthixol + MelitracenN/ASide Effects of Flupenthixol + MelitracenN/AContra-indications of Flupenthixol + MelitracenN/ASpecial Precautions while taking Flupenthixol + MelitracenN/APregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Flupenthixol + Melitracen1.Anxiety
2.Depression
3.Asthenia
Interactions for Flupenthixol + MelitracenN/ATypical Dosage for Flupenthixol + MelitracenAdult: 2 tablet to be taken daily
Maintenance dose: 1 tablet to be taken every morning
Each tablet contains Flupenthixol 0.5 mg + Melitracen 10 mgSchedule of Flupenthixol + MelitracenN/AStorage Requirements for Flupenthixol + MelitracenN/AEffects of Missed Dosage of Flupenthixol + MelitracenN/AEffects of Overdose of Flupenthixol + MelitracenN/AFlupenthixol
About FlupenthixolFirst-Generation Antipsychotic, a thioxanthene derivative, Typical Antipsychotic.Mechanism of Action of FlupenthixolFlupenthixol exerts its antipsychotic action by blocking post synaptic Dopamine receptor in the limbic system. It is a potent antagonist of D1&D2 receptors.
Flupenthixol is an alpha adrenergic receptor blocker and depresses many hypophyseal and hypothalamic hormones. It also blocks Prolactin inhibitory factor (PIF) and results in hyperprolactinemia.
Pharmacokinets of FlupenthixolAbsorption: Flupenthixol is slowly and incompletely absorbed after oral administration. Its bioavailability is only 50 % because it undergoes first pass metabolism. Distribution: It is distributed widely in the body in protein bound form. Metabolism: It is metabolised in the liver to inactive metabolites. Excretion: It is excreted mainly through faeces and small amount through urine.Onset of Action for Flupenthixol2 - 3 weeksDuration of Action for Flupenthixol1 - 3 daysHalf Life of Flupenthixol19 - 39 hoursSide Effects of Flupenthixol1.Psychoses
2.Depression
Contra-indications of Flupenthixol1.Tardive dyskinesia
2.Extrapyramidal reactions
3.Rigidity
4.Tremor
5.Insomnia
6.Restlessness
7.Dry mouth
8.Weight gain
9.Sexual dysfunction
10.Nausea
11.Epigastric distress
12.Galactorrhea
Special Precautions while taking Flupenthixol1.Renal impairment
2.Hepatic impairment
3.Cardiovascular disease
4 Respiratory disorder
5.Epilepsy
6.Bone marrow suppression
7.Prolactin dependent cancer
8.Caution while driving vehicle or operating machines or involve in any hazardous activities
9.Alcoholics
Pregnancy Related InformationContraindicated.Old Age Related InformationUse with cautionBreast Feeding Related InformationContraindicated.Children Related InformationContraindicated
NEONATES: ContraindicatedIndications for Flupenthixol1.Psychoses
2.Depression with or without anxiety.
Interactions for FlupenthixolN/ATypical Dosage for FlupenthixolAdult:
Depression: 0.5 mg 2 times a day if needed dose can be increased to 2 mg / day after 1 week.
Maximum dose: 3 mg / day
Psychoses: 3 mg 2 times daily dose can be gradually increase to 18 mg / day if needed.
DEPOT INJECTION:
Test dose: 20 mg after 1 week 20 - 40mg and repeat it every 2 - 4 week. Adjust according to response.
Maximum dose: 400 mg /week
Schedule of FlupenthixolHStorage Requirements for FlupenthixolStore at 15 - 30 degree C in a tightly closed container. Keep out of the reach of children. Protect from heat and light.Effects of Missed Dosage of FlupenthixolTake the missed dose as soon as noticed. If it is the time to take the next dose then skip the missed dose and take that dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of FlupenthixolGive supportive measures and treatment. Melitracen
About MelitracenA tricyclic antidepressant, Antidepressant.Mechanism of Action of MelitracenMelitracen acts by decreasing reuptake of Norepinephrine and Serotonin at the synapse resulting in high concentration of these neurotransmitters at the post-synaptic end. Thus it produces its antidepressant effect.Pharmacokinets of MelitracenAbsorption: It is well absorbed orally.Onset of Action for MelitracenN/ADuration of Action for MelitracenN/AHalf Life of MelitracenN/ASide Effects of Melitracen1.Weakness
2.Drowsiness
3.Anxiety
4.Insomnia
5.Dry mouth.
6.Difficulty in breathing
7.Headache
8.Weight gain
9.Nausea
10.Upset stomach
11.Decreased appetite
12.Diarrhea
13.Sweating
14.Blurred vision
15.Dizziness.
Contra-indications of Melitracen1.Hypersensitivity to Melitracen
2.Myocardial infarction
3.Narrow angle glaucoma
4.Bipolar disorder
5.Epilepsy
6.Patient on MAOI therapySpecial Precautions while taking MelitracenN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Melitracen1.DepressionInteractions for MelitracenN/ATypical Dosage for MelitracenAdult:1 - 2 tablet to be taken daily.Schedule of MelitracenN/AStorage Requirements for MelitracenStore the medicine in the tightly closed container. Keep out of the reach of children. Store it at room temperature and away from excess heat and moisture.Effects of Missed Dosage of MelitracenTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of MelitracenGive supportive measures and symptomatic treatment.Home Delivery for Flupenthixol + Melitracen in Your City
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Flupenthixol + Melitracen is a generic medicine name and there are several brands available for it. Some of the brands for flupenthixol + melitracen might be better known than flupenthixol + melitracen itself. If the pharmacy that's willing to deliver medicines to your home doesn't have flupenthixol + melitracen in stock, you can ask for one of the branded alternatives for flupenthixol + melitracen.