Niacin Pharmacology

Niacin

About Niacin
Water Soluble Vitamin(B complex-vitamin B3), Miscellaneous Antilipemic,peripheral vasodilator.
Mechanism of Action of Niacin
Niacin refers to Nicotinic acid as well as Nicotinamide which exerts it`s action by influencing metabolic reactions. It is converted in to coenzymes Ncotinamide adenine dinucleotide (NAD) and it`s phosphate Ncotinamide adenine dinucleotide phosphate (NADP) involved in oxidation reduction reactions. These pyridine nucleotides act as hydrogen acceptors in the electron transport chain in tissue respiration, glycolysis, and fat synthesis. Nicotinic acid in high doses has vasodilator effects and also improves lipid profile; reduces serum cholesterol, raises HDL level, lowers VLDL, and LDL levels.
Pharmacokinets of Niacin
Absorption: Well absorbed orally, Distribution: Widely distributed in the body, and also secreted in to breast milk, Modest amounts are stored in liver, Metabolism: Metabolized in to active metabolites in liver, Excretion: Extra drug is excreted through urine.
Onset of Action for Niacin
N/A
Duration of Action for Niacin
N/A
Half Life of Niacin
N/A
Side Effects of Niacin
1.Flushing
2.Activation of peptic ulcer
3.Nausea
4.Vomiting
5.Diarrhoea
6.Headache
7.Rashes
8.Pruritus
9.Hypotension
10.Arrhythmias
11.Hepatic impairment.
Contra-indications of Niacin
1.Hypersensitivity to the drug
2.Hepatic impairment
3.Peptic ulcer
4.Severe hypotension
5.Arterial haemorrhage.
Special Precautions while taking Niacin
1. History of liver disease
2.Gall bladder diseases
3.Gout
4.Coronary artery diseases
5.Diabetes mellitus
6.When use along with Statins reduces the dosage of Statins.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Niacin
1.Pellagra
2.Niacin deficiency
3.Hartnup disease
4.Hyperlipidaemia (only nicotinic acid
5.Peripheral vascular diseases (only nicotinic acid).
Interactions for Niacin
N/A
Typical Dosage for Niacin
Oral:
Pellagra: 200 to 500mg daily in divided doses.
Prophylactically: 20 to 50mg daily.
Dietary supplement: 10 to 20mg daily
Peripheral vascular diseases (only nicotinic acid): 100 to 150mg three to five times daily. Alternatively 1000 to 2000g once daily at bed time.
Hyperlipidaemia (only nicotinic acid): 1.5 to 6g daily in two to four divided doses with or after meals.
Hartnup disease: 50 to 200mg daily in divided doses.
Schedule of Niacin
N/A
Storage Requirements for Niacin
Store at controlled room temperature at a range of 15 to 30 degree C.
Effects of Missed Dosage of Niacin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Niacin
Provide supportive measures and symptomatic treatment.

Home Delivery for Niacin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including niacin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for niacin and other medicines and health products. Home delivery services for niacin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take niacin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for niacin before they complete the sale. You can get this information while placing the order for niacin with the pharmacy.

Niacin is a generic medicine name and there are several brands available for it. Some of the brands for niacin might be better known than niacin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have niacin in stock, you can ask for one of the branded alternatives for niacin.