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- Pharmacology For Atorvastatin + Fenofibrate
Atorvastatin + Fenofibrate Pharmacology
Atorvastatin + Fenofibrate
About Atorvastatin + FenofibrateN/AMechanism of Action of Atorvastatin + FenofibrateN/APharmacokinets of Atorvastatin + FenofibrateN/AOnset of Action for Atorvastatin + FenofibrateN/ADuration of Action for Atorvastatin + FenofibrateN/AHalf Life of Atorvastatin + FenofibrateN/ASide Effects of Atorvastatin + FenofibrateN/AContra-indications of Atorvastatin + FenofibrateN/ASpecial Precautions while taking Atorvastatin + FenofibrateN/APregnancy Related InformationContraindicated; since Atorvastatin and Fenofibrate are contraindicated in Pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationContraindicated; since Atorvastatin and Fenofibrate are contraindicated in breast feeding mother. The combination generic cannot be used in LactationChildren Related InformationN/AIndications for Atorvastatin + Fenofibrate1.Combined hyperlipidemiaInteractions for Atorvastatin + FenofibrateN/ATypical Dosage for Atorvastatin + FenofibrateAdult: 1 tablet / day with mealsSchedule of Atorvastatin + FenofibrateN/AStorage Requirements for Atorvastatin + FenofibrateN/AEffects of Missed Dosage of Atorvastatin + FenofibrateN/AEffects of Overdose of Atorvastatin + FenofibrateN/AAtorvastatin
About AtorvastatinHMG-CoA Reductase Inhibitor, statins, Antilipemic agent.Mechanism of Action of AtorvastatinIt is a more potent statin which competitively inhibits the conversion of 3-hydroxy-3-methyl glutaryl coenzyme A (HMG CoA) to mevalonate. The drug exerts it`s action by specific inhibition of enzyme; 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMG CoA reductase) and reduces cholesterol synthesis up to 50% at therapeutic doses. This results in compensatory increase in low density lipoprotein (LDL) receptor expression in liver which ultimately leads to increased receptor mediated uptake and catabolism of intermediate density lipoprotein(IDL) and low density lipoprotein (LDL). It causes dose dependent lowering of LDL cholesterol and reduces hepatic synthesis of very low density lipoprotein (VLDL) and lowers plasma triglyceride levels. It also increases high density lipoprotein (HDL) levels. It also exerts antioxidant property.Pharmacokinets of AtorvastatinAbsorption: Readily absorbed orally, Distribution: Widely distributed in a highly protein bound form, Metabolism: Metabolized in liver in to active metabolite, Excretion: Excreted mainly through bile.Onset of Action for AtorvastatinN/ADuration of Action for AtorvastatinN/AHalf Life of Atorvastatin18 to 24 hoursSide Effects of Atorvastatin1.Headache
2.Dizziness
3.Insomnia
4.Alopecia
5.Anorexia
6.Abdominal discomfort
7.Heart burn
8.Abdominal pain
9.Nausea
10.Dyspepsia
11.Flatulence
12.Constipation
13.Abnormal liver function tests
14.Rash
15.Pruritus
16.Fatigue
17.Myositis
18.Chest pain
19.Impotence
20.Myopathy
21.Upper respiratory tract infections
Contra-indications of Atorvastatin1.Hypersensitivity to the drug
2.Active liver diseases
3.Persistent elevation of serum transaminase levels
Special Precautions while taking Atorvastatin
1.Monitor hepatic function tests and lipid levels before and periodically during therapy and stop drug if there is marked elevation of creatinine phosphokinase level
2.History of liver diseases
3.Alcoholics
4.In severe adverse effects and fever
Pregnancy Related InformationContraindicatedOld Age Related InformationMay be usedBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
Below 9years: ContraindicatedIndications for Atorvastatin1.Hypercholesterolemia
2.Combined hyperlipidaemia
Interactions for AtorvastatinN/ATypical Dosage for AtorvastatinOral:
Starts with 10mg once daily; Increased if required based on patients response.
Maximum dose: 80mg
Schedule of AtorvastatinHStorage Requirements for AtorvastatinStore at room temperature at a range of 15 to 25 degree C.Effects of Missed Dosage of AtorvastatinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AtorvastatinProvide supportive care and symptomatic treatment.Fenofibrate
About FenofibrateFibric Acid Derivative, PPARa agonist, Antilipemic agent, Antigout.Mechanism of Action of FenofibrateIt is prodrug which has greater LDL (low density lipoprotein) cholesterol lowering potential. It lowers circulating triglyceride levels by activating lipoprotein lipase which is a key enzyme in the degradation of VLDL (very low density lipoprotein) cholesterol. This effect is exerted through paroxisome proliferator-activated receptor alpha (PPARalpha) which enhances lipoprotein lipase synthesis and fatty acid oxidation. It also reduces hepatic triglyceride synthesis. It also reduces VLDL levels and increases HDL (high density lipoprotein) cholesterol. The increase in HDL cholesterol is partly due to transfer of surface lipid components from catabolised VLDL to HDL and also due to increased production of HDL apoproteins by liver.Pharmacokinets of FenofibrateAbsorption: Well absorbed orally, food increases the absorption.
Distribution: Widely distributed in a protein bound form
Metabolism: Metabolized by ester hydrolysis to active metabolite which undergoes glucuronide conjugation in liver.
Excretion: Excreted mainly through urine and a small portion is excreted through faeces.
Onset of Action for FenofibrateN/ADuration of Action for FenofibrateN/AHalf Life of Fenofibrate20 hoursSide Effects of Fenofibrate1. Myalgia
2. Arthralgia
3. Hepatitis
4. Rashes
5. Headache
6. Dizziness
7. Arrhythmia
8. Photosensitivity
9. Fatigue
10. Asthenia
11. Paresthesia
12. Cough
13. Rhinitis
14. Sinusitis
15. Vaginitis
16. Allergic reactions
17. Alveolitis
18. Dyspepsia
19. Impotence
20. Myasthenia
Contra-indications of Fenofibrate1. Hypersensitivity to the drug
2. Severe hepatic impairment
3. Severe renal impairment
4. Gall bladder disease
Special Precautions while taking Fenofibrate1. Renal impairment; dosage adjustment is required
2. Hepatic impairment
3. Monitor lipid profile blood count and hepatic function before and periodically during therapy
4. If response is inadequate after 3 months therapy.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Fenofibrate1. Hyper lipidaemia (Type IIa, IIb, III, IV, and V) unresponsive to diet alone.Interactions for FenofibrateN/ATypical Dosage for FenofibrateOral: 200mg once daily with food. Adjust the dosage based on patient`s response.Schedule of FenofibrateHStorage Requirements for FenofibrateStore at controlled room temperature at a range of 15 to 25 degree C. Protect from light and humidity.Effects of Missed Dosage of FenofibrateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of FenofibrateDrug is removed from the body by induced emesis and gastric lavage. Treatment is supportive and symptomatic.Home Delivery for Atorvastatin + Fenofibrate in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for atorvastatin + fenofibrate and other medicines and health products. Home delivery services for atorvastatin + fenofibrate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take atorvastatin + fenofibrate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for atorvastatin + fenofibrate before they complete the sale. You can get this information while placing the order for atorvastatin + fenofibrate with the pharmacy.
Atorvastatin + Fenofibrate is a generic medicine name and there are several brands available for it. Some of the brands for atorvastatin + fenofibrate might be better known than atorvastatin + fenofibrate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have atorvastatin + fenofibrate in stock, you can ask for one of the branded alternatives for atorvastatin + fenofibrate.