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- Pharmacology For Aspirin (Low Dose) + Calcium + Citric acid
Aspirin (Low Dose) + Calcium + Citric acid Pharmacology
Aspirin (Low Dose) + Calcium + Citric acid
About Aspirin (Low Dose) + Calcium + Citric acidN/AMechanism of Action of Aspirin (Low Dose) + Calcium + Citric acidN/APharmacokinets of Aspirin (Low Dose) + Calcium + Citric acidN/AOnset of Action for Aspirin (Low Dose) + Calcium + Citric acidN/ADuration of Action for Aspirin (Low Dose) + Calcium + Citric acidN/AHalf Life of Aspirin (Low Dose) + Calcium + Citric acidN/ASide Effects of Aspirin (Low Dose) + Calcium + Citric acidN/AContra-indications of Aspirin (Low Dose) + Calcium + Citric acidN/ASpecial Precautions while taking Aspirin (Low Dose) + Calcium + Citric acidN/APregnancy Related InformationContraindicated; since Aspirin (low dose) is contraindicated in pregnancy. So the combination generic cannot be used in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationContraindicated; since Aspirin (low dose) is contraindicated in lactation.Children Related InformationN/AIndications for Aspirin (Low Dose) + Calcium + Citric acid1. Myocardial infarctionInteractions for Aspirin (Low Dose) + Calcium + Citric acidN/ATypical Dosage for Aspirin (Low Dose) + Calcium + Citric acid1 - 3 tablets / daySchedule of Aspirin (Low Dose) + Calcium + Citric acidN/AStorage Requirements for Aspirin (Low Dose) + Calcium + Citric acidN/AEffects of Missed Dosage of Aspirin (Low Dose) + Calcium + Citric acidN/AEffects of Overdose of Aspirin (Low Dose) + Calcium + Citric acidN/AAspirin (Low Dose)
About Aspirin (Low Dose)Salicylate, Anti platelet.Mechanism of Action of Aspirin (Low Dose)The drug exerts it`s antithrombotic action by interfering with platelet aggregation. It irreversibly inactivating and inhibiting the enzymes cyclooxygenase and thromboxane-synthetase. At lower doses it selectively suppresses the release of thromboxane-A2 till fresh platelets are formed. It also inhibits the release of ADP from platelets and their sticking to each other.Pharmacokinets of Aspirin (Low Dose)Absorption: Well absorbed orally, Distribution: Widely distributed in the body in a protein bound form, Metabolism: Metabolized in the liver in to metabolites. Excretion: Excreted through urine as salicylates and it`s metabolites.Onset of Action for Aspirin (Low Dose)N/ADuration of Action for Aspirin (Low Dose)5 to 7daysHalf Life of Aspirin (Low Dose)15 to 20minutesSide Effects of Aspirin (Low Dose)1.Prolonged bleeding time
2.Thrombocytopenia
3.Gastrointestinal disturbances
4.Allergic reactions
5.Rash
6.Urticaria
7.Angioedema
Contra-indications of Aspirin (Low Dose)1.Hypersensitivity to the drug
2.Peptic ulcer
3.Severe renal impairment
4.Severe hepatic impairment
5.G6PD deficiency
6.Haemorrhagic disorders
Special Precautions while taking Aspirin (Low Dose)
1.Hypo prothrobinemia
2.Renal impairment
3.Hepatic impairment
4.In gastrointestinal lesions
5.Vitamin K deficiency
6.Thrombotic thrombocytopenic purpura
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Aspirin (Low Dose)Prophylaxis treatment of increased risks of blood clottingInteractions for Aspirin (Low Dose)Drugs Affecting Aspirin:
Activated charcoal: Decreases absorption of aspirin.
Antacids Urinary alkalizers and Cortiosteroids: Decrease efficacy of aspirin.
Drugs affected by aspirin:
Alcohol: Risk of G.I. ulceration increases; may also prolong bleeding time.
ACE inhibitors: Antihypertensive action decreased.
Oral Anticoagulants : May potentiate effect.
Methotrexate: Effect potentiated.
Tetracycline: Efficacy decreased.
Tricyclic Antidepressants - Effect potentiated.
Nitroglycerin: May result in unexpected hypotension.
Beta-adrenergic Blockers - Antihypertensive effect blunted.
NSAIDs: May decrease serum concentration.
Sulfonylureas and Exogenous Insulin: In high doses may potentiate these drugs.
Valproic Acid: Potentiates effect.
Spironolactone: May inhibit diuretic effect.
Probenecid & Sulfinpyrazone : Antagonise uricosuric effect (In doses > 3gm/day - uricosuric effect)
Lab Tests:
Thyroid Function Tests: Increase in PBI
Serum Uric Acid Levels: Increased by levels less than 10 mg/dl and decreased by levels> 10 mg/dl.
Urine Glucose: False negative by glucose oxidase method. False positive results by reduction method.
Urinary Ketones: Produce reddish colour.Typical Dosage for Aspirin (Low Dose)0ral: 50mg to 160mg/daySchedule of Aspirin (Low Dose)HStorage Requirements for Aspirin (Low Dose)Store at room temperature and protects from moisture.Effects of Missed Dosage of Aspirin (Low Dose)Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Aspirin (Low Dose)Empty stomach by induced emesis and gastric lavage. Reduce absorption by administration of activated charcoal. Give symptomatic and supportive treatment. Monitor and assist respiratory function, fluid and electrolyte balance, and other vital parameters. Administer sodium bicarbonate and enhance alkaline diuresis. Haemodialysis is effective in severe poisoning.Calcium
About CalciumCalcium is necessary for cardiac function, muscle contraction, nervous activity, coagulation of blood and for maintaining structural integrity of cell membranes.
Plasma concentration of calcium is kept in normal range by three endocrine factors which control metabolism of calcium. These are (a) Parathyroid hormone, (b) Calcitonin, (c) Vitamin D. Calcium in plasma is bound to albumin, is complexed with anions (e.g. phosphate) and as diffusible ionic calcium. The physiological effects are exerted by ionic calcium. The predominant source of calcium is dairy products and the daily intake varies from 200 - 2500 mg. Adequate calcium intake is particularly important during periods of bone growth in childhood and adolescence and during pregnancy and lactation.
Patients with advanced renal insufficiency exhibit phosphate retention and some degree of hyperphosphataemia. The retention of phosphate plays a pivotal role in causing secondary hyperparathyroidism associated with osteodystrophy and soft tissue calcification. Calcium acetate, when taken with meals, combines with dietary phosphate to form insoluble calcium phosphate which is excreted in the faeces.
Deficiency signs and symptoms: Osteoporosis, pathological fractures, brittle nails and hair.Mechanism of Action of CalciumCalcium is essential for maintaining the functional integrity of nervous, muscular, and skeletal system. It controls excitability of nerves and muscles and regulates permeability of cell membrane. It also regulates cell adhesion and maintains integrity of cell membrane. Calcium acts as intracellular messenger for hormones, autacoids, and transmitters. It is required for excitation-contraction coupling in all types of muscle and excitation-secretion coupling in exocrine and endocrine glands. It is essential for release of transmitters from nerve endings and other release reactions. It is also essential for impulse generation in heart and determines level of automaticity and
A-V conduction. Calcium is also required for blood-coagulation.
Pharmacokinets of CalciumAbsorption: Actively absorbed from gastrointestinal tract in an ionized form; and vitamin D in it`s active form is required for calcium absorption, Distribution: Distributed mainly in to skeletal tissue (99%) and 1% is distributed equally between the intracellular and extra cellular fluid. CSF levels are about half of the serum calcium levels, Metabolism: Not significantly metabolized in the body, Excretion: Excreted mainly through faeces and a small amount is excreted through urine.Onset of Action for CalciumN/ADuration of Action for CalciumN/AHalf Life of CalciumN/ASide Effects of Calcium1.Constipation
2.Bloating
3.Excess gas
4.Anorexia
5.Nausea
6.Vomiting
7.Abdominal pain
8.Thirst
9.Hypercalcaemia
10.Polyuria
11.Dry mouth
12.Delirium
13.Confusion
Contra-indications of Calcium1.Renal calculi
2.Hypophosphataemia
3.Hypercalcaemia
4.Ventricular fibrillation.
Special Precautions while taking Calcium1.Renal impairment
2.Cardiac diseases
3.Sarcoidosis
4.Cor pulmonale
5.Respiratory acidosis
6.Respiratory failure
7.End stage renal failure
8.Hypoparathyroid patients
9.Digitalized patients
10.Prolonged use of therapeutic amounts.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationMay be usedChildren Related InformationUse with cautionIndications for Calcium1.Hypocalcaemia
2.Calcium and vitamin D deficiency
3.Calcium deficiency during pregnancy and lactation
4.Rickets
5.Prevention of osteoporosis in postmenopausal women
6.Chronic renal failure.
Interactions for CalciumN/ATypical Dosage for CalciumOral: 500mg to 2g daily in two to four divided doses.
Hypocalcaemia:
Adults: 1g daily. Increases to 2g daily if required.
Prevention of osteoporosis: 1 to 1.5g daily.
Children: 45 to 65mg/kg daily.
Neonates: 50 to 150mg/kg and should not exceed 1g.
Schedule of CalciumN/AStorage Requirements for CalciumStore in a well closed container in a cool and dry place. Protect from light.
Effects of Missed Dosage of CalciumTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of CalciumRemove calcium from stomach by induced emesis and gastric lavage. Provide symptomatic treatment and supportive measures.Citric acid
About Citric acidWeak organic carboxylic acid, an alkalinizing agent, expectorant, antioxidant, flavouring agent.Mechanism of Action of Citric acidCitric acid is an organic acid which is used widely in medicine and also as flavouring agent. Citric acid is an alkalinizing agent which is used to make the urine more alkaline (less acidic).It prevents certain kinds of kidney stones. It is used in expectorant preparations to increase bronchial secretion. It also posses antioxidant properties.Pharmacokinets of Citric acidAbsorption: Administered orally, Excretion: Excreted through urine.Onset of Action for Citric acidN/ADuration of Action for Citric acidN/AHalf Life of Citric acidN/ASide Effects of Citric acid1 Polyuria
2.Hypernatremia
3.Metabolic alkalosis
4.Diarrhea
5.Loose bowel movements
6.Allergic reactions (rare)
7.Chest pain (rare)
8.Shortness of breath(rare)
Contra-indications of Citric acid1.Hypersensitivity to the drug
2.Patients on sodium-restricted diets
3.Renal impairment with oliguria, azotemia, or anuria
4.Acute dehydration
5.Heat cramps
6.Severe myocardial damage
7.Hyperkalemia.
Special Precautions while taking Citric acid1.Renal impairment
2.Edema
3.Hypertension
4.Along with other medication
5.Addison`s disease
6.Type 2 diabetes mellitus
7.Urolithiasis
8.Cardiac diseases
9.Toxemia of pregnancy
10.Urinary tract infections
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationMay be usedIndications for Citric acid1.Expectorant
2.Kidney stones
3.Gout
4.Urine and blood alkaliniser
5.Symptomatic treatment of nausea and vomiting
Interactions for Citric acidN/ATypical Dosage for Citric acidOral:
As alkaliniser: Dosage are individualized and varies in different combinations
Schedule of Citric acidN/AStorage Requirements for Citric acidStore in a cool dry area in a tightly closed container. Protect from direct light, heat, and moisture.Effects of Missed Dosage of Citric acidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Citric acidProvide symptomatic treatment and supportive measures.Home Delivery for Aspirin (Low Dose) + Calcium + Citric acid in Your City
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Aspirin (Low Dose) + Calcium + Citric acid is a generic medicine name and there are several brands available for it. Some of the brands for aspirin (low dose) + calcium + citric acid might be better known than aspirin (low dose) + calcium + citric acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have aspirin (low dose) + calcium + citric acid in stock, you can ask for one of the branded alternatives for aspirin (low dose) + calcium + citric acid.