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- Pharmacology For Clopidogrel + Aspirin (Low Dose)
Clopidogrel + Aspirin (Low Dose) Pharmacology
Clopidogrel + Aspirin (Low Dose)
About Clopidogrel + Aspirin (Low Dose)N/AMechanism of Action of Clopidogrel + Aspirin (Low Dose)N/APharmacokinets of Clopidogrel + Aspirin (Low Dose)N/AOnset of Action for Clopidogrel + Aspirin (Low Dose)N/ADuration of Action for Clopidogrel + Aspirin (Low Dose)N/AHalf Life of Clopidogrel + Aspirin (Low Dose)N/ASide Effects of Clopidogrel + Aspirin (Low Dose)N/AContra-indications of Clopidogrel + Aspirin (Low Dose)N/ASpecial Precautions while taking Clopidogrel + Aspirin (Low Dose)N/APregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Clopidogrel + Aspirin (Low Dose)It is a combination of 2 antithrombotics Clopidogrel and Aspirin.
1.Atherosclerosis
2.Peripheral arterial disease
3.Unstable angina
Interactions for Clopidogrel + Aspirin (Low Dose)N/ATypical Dosage for Clopidogrel + Aspirin (Low Dose)Adult: 1 tablet to be taken once daily.Schedule of Clopidogrel + Aspirin (Low Dose)N/AStorage Requirements for Clopidogrel + Aspirin (Low Dose)N/AEffects of Missed Dosage of Clopidogrel + Aspirin (Low Dose)N/AEffects of Overdose of Clopidogrel + Aspirin (Low Dose)N/AClopidogrel
About ClopidogrelThienopyridine class, Platelet Aggregation Inhibitor, Antithrombic, Anti platelet agent.Mechanism of Action of ClopidogrelThe drug exerts it`s antithrombotic action by interfering with platelet aggregation. It alters surface receptors in platelets and inhibits ADP induced platelet-fibrinogen and platelet-platelet binding and prevents platelet aggregation. It blocks G-protein coupled P2YAC type of inhibitory purinergic receptors which mediates adenylyl cyclase inhibition by ADP. It prolongs bleeding time.Pharmacokinets of ClopidogrelAbsorption: About 50% of drug is absorbed orally.Distribution: Widely distributed in the body in a protein bound form.Metabolism: Metabolized in liver. Excretion: About 50% is excreted through urine and 46% is excreted through faeces as metabolites.
Onset of Action for Clopidogrel2hoursDuration of Action for Clopidogrel5daysHalf Life of Clopidogrel8 hoursSide Effects of Clopidogrel1.Diarrhoea
2.Vomiting
3.Nausea
4.Abdominal pain
5.Headache
6.Tinnitus
7.Rash
8.Pruritus
9.Haemorrhage
10.Neutropenia (rare)
11.Thrombocytopenia (are)
Contra-indications of Clopidogrel1. Hypersensitivity to the drug
2. Haemorrhagic disorders
3. Intracranial haemorrhage
4. Gastrointestinal tract ulcer
Special Precautions while taking Clopidogrel1.Haemopoetic disorders
2.Renal impairment
3.Hepatic impairment
4.Trauma
5. Recent surgery
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicated.Children Related InformationContraindicatedIndications for Clopidogrel1. To reduce atherosclerotic events
2. Thrombotic disorders
3. Prevention of stroke
4. Prophylaxis of myocardial infarction
5. Peripheral vascular diseases
6. Coronary artery diseases.
Interactions for ClopidogrelAsprin: Potentiates the effect of aspirin on collagen-induced platelet aggregation.
NSAIDs: Risk of increased occult gastrontestinal blood loss.
Phenytoin, tamoxifen, tolbutamide, warfarin, torsemide, fluvastatin: Since clopidogrel inhibits CYP4502C9 it may interfere with the metabolism of these drugs.Typical Dosage for ClopidogrelOral: 75mg/day as single dose. Schedule of ClopidogrelN/AStorage Requirements for ClopidogrelStore at room temperature at a range of 15 to 30 degree C. Protect from excess heat and moistureEffects of Missed Dosage of ClopidogrelTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ClopidogrelProvide supportive treatment. Platelet transfusion reverses the effects of the drug.Aspirin (Low Dose)
About Aspirin (Low Dose)Salicylate, Anti platelet.Mechanism of Action of Aspirin (Low Dose)The drug exerts it`s antithrombotic action by interfering with platelet aggregation. It irreversibly inactivating and inhibiting the enzymes cyclooxygenase and thromboxane-synthetase. At lower doses it selectively suppresses the release of thromboxane-A2 till fresh platelets are formed. It also inhibits the release of ADP from platelets and their sticking to each other.Pharmacokinets of Aspirin (Low Dose)Absorption: Well absorbed orally, Distribution: Widely distributed in the body in a protein bound form, Metabolism: Metabolized in the liver in to metabolites. Excretion: Excreted through urine as salicylates and it`s metabolites.Onset of Action for Aspirin (Low Dose)N/ADuration of Action for Aspirin (Low Dose)5 to 7daysHalf Life of Aspirin (Low Dose)15 to 20minutesSide Effects of Aspirin (Low Dose)1.Prolonged bleeding time
2.Thrombocytopenia
3.Gastrointestinal disturbances
4.Allergic reactions
5.Rash
6.Urticaria
7.Angioedema
Contra-indications of Aspirin (Low Dose)1.Hypersensitivity to the drug
2.Peptic ulcer
3.Severe renal impairment
4.Severe hepatic impairment
5.G6PD deficiency
6.Haemorrhagic disorders
Special Precautions while taking Aspirin (Low Dose)
1.Hypo prothrobinemia
2.Renal impairment
3.Hepatic impairment
4.In gastrointestinal lesions
5.Vitamin K deficiency
6.Thrombotic thrombocytopenic purpura
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Aspirin (Low Dose)Prophylaxis treatment of increased risks of blood clottingInteractions for Aspirin (Low Dose)Drugs Affecting Aspirin:
Activated charcoal: Decreases absorption of aspirin.
Antacids Urinary alkalizers and Cortiosteroids: Decrease efficacy of aspirin.
Drugs affected by aspirin:
Alcohol: Risk of G.I. ulceration increases; may also prolong bleeding time.
ACE inhibitors: Antihypertensive action decreased.
Oral Anticoagulants : May potentiate effect.
Methotrexate: Effect potentiated.
Tetracycline: Efficacy decreased.
Tricyclic Antidepressants - Effect potentiated.
Nitroglycerin: May result in unexpected hypotension.
Beta-adrenergic Blockers - Antihypertensive effect blunted.
NSAIDs: May decrease serum concentration.
Sulfonylureas and Exogenous Insulin: In high doses may potentiate these drugs.
Valproic Acid: Potentiates effect.
Spironolactone: May inhibit diuretic effect.
Probenecid & Sulfinpyrazone : Antagonise uricosuric effect (In doses > 3gm/day - uricosuric effect)
Lab Tests:
Thyroid Function Tests: Increase in PBI
Serum Uric Acid Levels: Increased by levels less than 10 mg/dl and decreased by levels> 10 mg/dl.
Urine Glucose: False negative by glucose oxidase method. False positive results by reduction method.
Urinary Ketones: Produce reddish colour.Typical Dosage for Aspirin (Low Dose)0ral: 50mg to 160mg/daySchedule of Aspirin (Low Dose)HStorage Requirements for Aspirin (Low Dose)Store at room temperature and protects from moisture.Effects of Missed Dosage of Aspirin (Low Dose)Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Aspirin (Low Dose)Empty stomach by induced emesis and gastric lavage. Reduce absorption by administration of activated charcoal. Give symptomatic and supportive treatment. Monitor and assist respiratory function, fluid and electrolyte balance, and other vital parameters. Administer sodium bicarbonate and enhance alkaline diuresis. Haemodialysis is effective in severe poisoning.Home Delivery for Clopidogrel + Aspirin (Low Dose) in Your City
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Clopidogrel + Aspirin (Low Dose) is a generic medicine name and there are several brands available for it. Some of the brands for clopidogrel + aspirin (low dose) might be better known than clopidogrel + aspirin (low dose) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have clopidogrel + aspirin (low dose) in stock, you can ask for one of the branded alternatives for clopidogrel + aspirin (low dose).