Polygeline Pharmacology

Polygeline

About Polygeline
I.V fluids ,Plasma substitutes, A plasma expander.
Mechanism of Action of Polygeline
Polygeline is a plasma volume substitute. It corrects circulatory insufficiency due to deficient plasma or blood volume.
Pharmacokinets of Polygeline
Absorption: It is absorbed after intravenous infusion.Distribution: Apparent volume of distribution is 8L and is distributed between intravascular and extravascular compartments.Metabolism: Polygeline is broken down in to small peptides and aminoacids by proteolytic enzymes such as trypsin, plasmin or cathepsin.Excretion: Drug is excreted mainly in urine.
Onset of Action for Polygeline
N/A
Duration of Action for Polygeline
N/A
Half Life of Polygeline
5 - 8 hours
Side Effects of Polygeline
1.Urticaria
2.Flushing
3.Wheals
4.Hypotension
5.Irregular pulse rate
6.Nausea
7.Vomiting
8.Dyspnoea
9.Fever
10.Chills
11.Bronchospasm
12.Angioedema


Contra-indications of Polygeline
1. Hypersensitivity to Polygeline

Special Precautions while taking Polygeline
1.Citrated blood should not be mixed with Polygeline
2.Cardiac insufficiency
3.Hypertension
4.Pulmonary edema
5.Cardiogenic shock,
6.Esophageal varices
7.Anuria
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Polygeline
1. Hypovolaemic shock due to Hemorrhage (visible, concealed), Loss of plasma (burns, peritonitis, Pancreatitis, crush injuries), loss of water and electrolytes from persistent vomiting and diarrhea
2.Procedures involving extra corporeal circulation e.g. filling the heart-lung machine
3.Carrier for insulin infusion
4.lsolated organ perfusion

Interactions for Polygeline
In the case of pateints receiving cardiac glycosides, the synergestic effect in polygeline should be taken into account.
Typical Dosage for Polygeline
Polygeline infusion solution 3.5% w/v is availably
Adult: Dosage is determined on the clinical response and on the circulatory parameters such as blood pressure.
In shock prophylaxis: 500 - 1500 ml
Hypovolaemic shock: maximum up to 2000ml
Emergency: volume as required

Schedule of Polygeline
N/A
Storage Requirements for Polygeline
Store below 25 degree C.
Effects of Missed Dosage of Polygeline
Dosage is decided by health care professionals
Effects of Overdose of Polygeline
Give supportive measures and symptomatic treatment.

Home Delivery for Polygeline in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including polygeline.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for polygeline and other medicines and health products. Home delivery services for polygeline may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take polygeline only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for polygeline before they complete the sale. You can get this information while placing the order for polygeline with the pharmacy.

Polygeline is a generic medicine name and there are several brands available for it. Some of the brands for polygeline might be better known than polygeline itself. If the pharmacy that's willing to deliver medicines to your home doesn't have polygeline in stock, you can ask for one of the branded alternatives for polygeline.