S-Atenolol + Hydrochlorothiazide Pharmacology

S-Atenolol + Hydrochlorothiazide

About S-Atenolol + Hydrochlorothiazide
N/A
Mechanism of Action of S-Atenolol + Hydrochlorothiazide
N/A
Pharmacokinets of S-Atenolol + Hydrochlorothiazide
N/A
Onset of Action for S-Atenolol + Hydrochlorothiazide
N/A
Duration of Action for S-Atenolol + Hydrochlorothiazide
N/A
Half Life of S-Atenolol + Hydrochlorothiazide
N/A
Side Effects of S-Atenolol + Hydrochlorothiazide
N/A
Contra-indications of S-Atenolol + Hydrochlorothiazide
N/A
Special Precautions while taking S-Atenolol + Hydrochlorothiazide
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for S-Atenolol + Hydrochlorothiazide
N/A
Interactions for S-Atenolol + Hydrochlorothiazide
N/A
Typical Dosage for S-Atenolol + Hydrochlorothiazide
N/A
Schedule of S-Atenolol + Hydrochlorothiazide
N/A
Storage Requirements for S-Atenolol + Hydrochlorothiazide
N/A
Effects of Missed Dosage of S-Atenolol + Hydrochlorothiazide
N/A
Effects of Overdose of S-Atenolol + Hydrochlorothiazide
N/A

S-Atenolol

About S-Atenolol
Cardioselective Beta(Beta1 )-adrenergic blocking agent, Antihypertensive,anti anginal.
Mechanism of Action of S-Atenolol
S-Atenolol is a cardio selective beta-1 adrenergic antagonist.
It has negative chronotropic effects on exercise induced heart rate. It decreases oxygen consumption; cardiac work and aortic pressure it decreases nor adrenaline and renin releases. It decreases central sympathetic out flow. In sympathetic over activity, it prolongs systole by retarding conduction. It increases oxygen supply and exercise tolerance in angina patients. The drug decreases BP in hypertensive individuals; both systolic and diastolic BP is reduced. It lowers free fatty acid levels.

Pharmacokinets of S-Atenolol
N/A
Onset of Action for S-Atenolol
N/A
Duration of Action for S-Atenolol
N/A
Half Life of S-Atenolol
N/A
Side Effects of S-Atenolol
1.Tiredness
2.Bradycardia
3.Cold extremities
4.Fatigue
5.Heart failure

Contra-indications of S-Atenolol
1.Hypersensitivity to the drug or recemic Atenolol
2.Second or third degree heart block
3.Cardiogenic shock
Special Precautions while taking S-Atenolol
1.Renal impairment
2.The drug should be gradually withdraw with caution
3.Diabetes mellitus

Pregnancy Related Information
Use with caution
Old Age Related Information
N/A
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for S-Atenolol
1.Hypertension
2.Angina
3.Myocardial infarction

Interactions for S-Atenolol
N/A
Typical Dosage for S-Atenolol
Hypertension, Angina, Myocardial infarction:
Starts with 12.5mg once daily and increases to 25mg once daily
Stage-2 hypertension: Starts with 12.5mg once daily and increases to 50mg once daily

Schedule of S-Atenolol
H
Storage Requirements for S-Atenolol
Store at room temperature and protect from heat, moisture, and direct sunlight
Effects of Missed Dosage of S-Atenolol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of S-Atenolol
Give supportive measures and symptomatic treatment.

Hydrochlorothiazide

About Hydrochlorothiazide
Thiazide derivatibve, Diuretic.
Mechanism of Action of Hydrochlorothiazide
It is thiazide diuretic which exerts its action by acting at site-3(central dilating segment of early distal tubule). It binds to Na+Cl- symporter and inhibits Na+Cl- symport at the luminal membrane. It has additional carbonic anhydrase inhibitory actions in proximal tubules. It increases natriuresis, kaliuresis and diuresis. It decreases Ca2+ excretion and increases Mg2+excretion. It also has minor carbonic anhydrase inhibitory action. It also causes direct arteriolar vasodilatation and decreases total peripheral resistance. The antihypertensive actions of the drug may be attributable to depletion of sodium and subsequent reduction in plasma volume and a decrease in peripheral resistance. Decrease in peripheral resistance is due to either the loss of sodium from the arteriolar wall or a direct action on the vascular bed. It is an effective drug in edema associated with congestive heart failure.
Vertigo: Diuretics are used in vertigo in assumption that vertigo is due to endolymphatic hydrops. They reduce labyrinthine fluid pressure

Pharmacokinets of Hydrochlorothiazide
Absorption: It is absorbed after oral administration.
Metabolism: It is not metabolized in the body.
Excretion: Excreted unchanged in urine.

Onset of Action for Hydrochlorothiazide
1 to 3 hours
Duration of Action for Hydrochlorothiazide
12 to 16 hours
Half Life of Hydrochlorothiazide
5 to 15 hours
Side Effects of Hydrochlorothiazide
1. Dizziness
2. Blurred vision
3. Confusion
4. Tingling fingers
5. Dry mouth
6. Nausea
7. Diarrhoea
8. Constipation
9. Vomiting
10. Weakness
11. Hypokalaemia
12. Hyponatraemia
13. Hyperuricaemia
14. Elevated levels of glucose, calcium and lipids
15. Gastro intestinal disturbances
16. Polyuria
17. Electrolyte imbalance
18. Jaundice
19. Rashes
20. Photosensitivity
21. Fever
22. Itching
23. Myalgia
24. Muscle cramps
25. Arthralgia
26. Blood dyscrasias
27. Ototoxicity

Contra-indications of Hydrochlorothiazide
1. Hyper uricaemia
2. Hyper calcaemia
3. Renal impairment
4. Hepatic impairment
5. Anuria
6. Hypersensitivity to the drug
7. Hyper sensitivity to sulfonamides
8. Fluid and electrolyte imbalance

Special Precautions while taking Hydrochlorothiazide
1. Gout
2. Diabetes mellitus
3. Renal impairment
4. Hepatic impairment
5. Monitor and correct Fluid and electrolyte imbalance
6. Hyper parathyroidism
7. Cirrhosis

Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
May be used
Indications for Hydrochlorothiazide
1. Hypertension
2. Oedema associated with heart failure
3. Oedema due to renal and hepatic diseases
4. Diabetes insipidus
5. Idiopathic hypercalciurea.
6. Vertigo
Interactions for Hydrochlorothiazide
Cholestyramine & Colestipol: decrease absorption of hydrochlorothiazide.
Diazoxide: Additive action - may cause hyperglycemia, hyperuricaemia and hypotension.
Digitalis: Diuretics induced hypokalaemia may precipitate digitalis toxicity.
Lithium: Hydrochlorothiazide potentiates therapeutic and toxic effects by increasing its renal excretion.
Frusemide: Synergy leading to profound diuresis and greater than predicted electrolyte loss.
Non-depolarizing muscle relaxants: Diuretics induced hypokalaemia enhances efficacy.
Sulfonylureas: Efficacy decreased due to hydrochlorothiazide induced glucose intolerance.
Chlorpropamide: Hypokalaemia.
Propantheline: Bioavailability of hydrochlorothiazide increased.
Metoclopramide: Bioavailability of hydrochlorothiazide decreased.
NSAIDs: Natriuretic effect of hydrochlorothiazide decreased.
Typical Dosage for Hydrochlorothiazide
Adults:
Hypertension: 25mg once daily or in divided doses. Increased to 50mg if required; depending up on the patient`s response.
Children: 1mg/kg single daily dose.
Oedema:
Adults:
Starts with 25 to 50mg. Increased the dose until desired response is obtained.
Maximum dose: 200mg/day
Maintenance dosage: 25 to 100mg daily or on alternate days.
Children: 1mg/kg single daily dose or 1 to 3mg/kg/day in two divided doses



Schedule of Hydrochlorothiazide
G
Storage Requirements for Hydrochlorothiazide
Store at room temperature in a well closed container and protected from light.
Effects of Missed Dosage of Hydrochlorothiazide
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Continue the regular schedule.Do not double the dose.
Effects of Overdose of Hydrochlorothiazide
Treatment is supportive and symptomatic. Remove drug from the body by induced emesis and gastric lavage. Monitor and assist respiratory, cardiovascular, and renal function as indicated. Monitor and support fluid and electrolyte balance.

Home Delivery for S-Atenolol + Hydrochlorothiazide in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including s-atenolol + hydrochlorothiazide.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for s-atenolol + hydrochlorothiazide and other medicines and health products. Home delivery services for s-atenolol + hydrochlorothiazide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take s-atenolol + hydrochlorothiazide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for s-atenolol + hydrochlorothiazide before they complete the sale. You can get this information while placing the order for s-atenolol + hydrochlorothiazide with the pharmacy.

S-Atenolol + Hydrochlorothiazide is a generic medicine name and there are several brands available for it. Some of the brands for s-atenolol + hydrochlorothiazide might be better known than s-atenolol + hydrochlorothiazide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have s-atenolol + hydrochlorothiazide in stock, you can ask for one of the branded alternatives for s-atenolol + hydrochlorothiazide.