Tinidazole + Diloxanide Furoate + Dimethyl polysiloxane + Homatropine Pharmacology

Tinidazole + Diloxanide Furoate + Dimethyl polysiloxane + Homatropine

About Tinidazole + Diloxanide Furoate + Dimethyl polysiloxane + Homatropine

N/A

Mechanism of Action of Tinidazole + Diloxanide Furoate + Dimethyl polysiloxane + Homatropine

N/A

Pharmacokinets of Tinidazole + Diloxanide Furoate + Dimethyl polysiloxane + Homatropine

N/A

Onset of Action for Tinidazole + Diloxanide Furoate + Dimethyl polysiloxane + Homatropine

N/A

Duration of Action for Tinidazole + Diloxanide Furoate + Dimethyl polysiloxane + Homatropine

N/A

Half Life of Tinidazole + Diloxanide Furoate + Dimethyl polysiloxane + Homatropine

N/A

Side Effects of Tinidazole + Diloxanide Furoate + Dimethyl polysiloxane + Homatropine

N/A

Contra-indications of Tinidazole + Diloxanide Furoate + Dimethyl polysiloxane + Homatropine

N/A

Special Precautions while taking Tinidazole + Diloxanide Furoate + Dimethyl polysiloxane + Homatropine

N/A

Pregnancy Related Information

N/A

Old Age Related Information

N/A

Breast Feeding Related Information

N/A

Children Related Information

N/A

Indications for Tinidazole + Diloxanide Furoate + Dimethyl polysiloxane + Homatropine

N/A

Interactions for Tinidazole + Diloxanide Furoate + Dimethyl polysiloxane + Homatropine

N/A

Typical Dosage for Tinidazole + Diloxanide Furoate + Dimethyl polysiloxane + Homatropine

N/A

Schedule of Tinidazole + Diloxanide Furoate + Dimethyl polysiloxane + Homatropine

N/A

Storage Requirements for Tinidazole + Diloxanide Furoate + Dimethyl polysiloxane + Homatropine

N/A

Effects of Missed Dosage of Tinidazole + Diloxanide Furoate + Dimethyl polysiloxane + Homatropine

N/A

Effects of Overdose of Tinidazole + Diloxanide Furoate + Dimethyl polysiloxane + Homatropine

N/A

Tinidazole

About Tinidazole

Nitroimidazole antibiotic, Antibacterial, antiprotozoal.

Mechanism of Action of Tinidazole

Tinidazole is nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which excerts cytotoxic action by damaging DNA and other critical biomolecules. 3. .DNA helix destabilization &strand breakage has been observed.

Pharmacokinets of Tinidazole

Absorption: Well absorbed orally, Distribution: Widely distributed,
Metabolism: Metabolized in liver by oxidation &glucuronide conjugation, Excretion: Excreted in urine.

Onset of Action for Tinidazole

Within few hours

Duration of Action for Tinidazole

16 hours

Half Life of Tinidazole

12 hours

Side Effects of Tinidazole

1.Anorexia
2.Bitter taste
3.Nausea
4.Vomiting
5.Diarrhoea
6.Fatigue
7.Dry mouth
8.Abdominal distress
9.Headache
10.Dizziness
11.Vertigo
12.Rash
13.Urticaria
14.Angioedema
15.Peripheral neuropathy & CNS effects,

Contra-indications of Tinidazole

1.Hypersensitivity to the drug
2.Blood dyscrasias
3.CNS disorders

Special Precautions while taking Tinidazole

1.Hepatic impairment
2.Alcoholic cirrhosis
3.Obstructive liver diseases
4. Use cautiously along with other hepatotoxic drugs & In visual field changes
5. Avoid alcohol use during therapy

Pregnancy Related Information

Use with caution, but contra indicated in first trimester

Old Age Related Information

N/A

Breast Feeding Related Information

Contraindicated

Children Related Information

N/A

Indications for Tinidazole

1.Amoebiasis
2.Giardiasis
3.Trichomonas vaginitis
4.Anaerobic bacterial infections
5.Prophylactic agent after colorectal surgery
6.H. pylori infections

Interactions for Tinidazole

Alcohol: Disulfiram like reaction.
Ampicillin, Doxycycline and Cotrimoxaole: Synergism with these agents.

Typical Dosage for Tinidazole

Amoebiasis:
Adults: 2gm once daily for 3 days
Children: 30 to 50mg/kg/day or 600mg 12hourly for 5 to 10 days
Trichomoniasis & Giardiasis:
600mg once daily for a week or 2gm single dose
Anaerobic bacterial infections:
2 gm followed by 500mg 12 hourly for 5 days
Prophylaxis after colorectal surgery:
2gm single dose before surgery
H. pylori infections:
0.5gm 12hourly for 7 to14 days in triple combination

Schedule of Tinidazole

Storage Requirements for Tinidazole

Store at room temperature at a range of 15 to 30 degree C. Protect from excess heat and moisture.

Effects of Missed Dosage of Tinidazole

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Tinidazole

Treatment is supportive & symptomatic. Drug is removed by induced emesis, gastric lavage, and administration of activated charcoal &use of cathartics. For controlling seizures diazepam & phenytoin may be used

Diloxanide Furoate

About Diloxanide Furoate

Dichloroacetamide derivative, anti-protozoal, Luminal amebicides.

Mechanism of Action of Diloxanide Furoate

Diloxanide Furoate is a dicloroacetamide derivative which acts as a luminal amoebicide. It exerts its action by directly killing the trophozoites responsible for production of cysts.

Pharmacokinets of Diloxanide Furoate

Absorption: Orally well absorbed.
Metabolism: It is metabolized by glucuronide conjugation.
Excretion: Excreted through urine.

Onset of Action for Diloxanide Furoate

N/A

Duration of Action for Diloxanide Furoate

N/A

Half Life of Diloxanide Furoate

N/A

Side Effects of Diloxanide Furoate

1. Flatulence
2. Nausea
3. Itching
4. Urticaria rashes

Contra-indications of Diloxanide Furoate

N/A

Special Precautions while taking Diloxanide Furoate

1. Hepatic impairment

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

Use with caution
Below 2 years : Contraindicated

Indications for Diloxanide Furoate

1. Mild intestinal Amoebiasis,
2. Asymptomatic cyst passers of Entamoeba histolitica

Interactions for Diloxanide Furoate

No known interaction.

Typical Dosage for Diloxanide Furoate

Adults: 0.5gm 8hourly for 5 to 10days.
Children (above 2years): 20mg/kg/day in divided doses up to 10days.

Schedule of Diloxanide Furoate

Storage Requirements for Diloxanide Furoate

Store in a cool dry place.Protect from heat and light.Keep out of the reach of children.

Effects of Missed Dosage of Diloxanide Furoate

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Diloxanide Furoate

Give supportive measures and symptomatic treatment.

Dimethyl polysiloxane

About Dimethyl polysiloxane

A silicone derivative,Anti-foaming agent, Antiflatulent.

Mechanism of Action of Dimethyl polysiloxane

Dimethyl polysiloxane is a silicone derivative which is used in symptomatic treatment of postprandial and postoperative flatulence and abdominal distension.It acts as defoaming agent and eliminates gases from GI tract.It is used in combination with antacids,antispasmodics and digestants.

Pharmacokinets of Dimethyl polysiloxane

N/A

Onset of Action for Dimethyl polysiloxane

N/A

Duration of Action for Dimethyl polysiloxane

N/A

Half Life of Dimethyl polysiloxane

N/A

Side Effects of Dimethyl polysiloxane

N/A

Contra-indications of Dimethyl polysiloxane

Hypersensitivity to Dimethyl Polysiloxane

Special Precautions while taking Dimethyl polysiloxane

Kidney failure

Pregnancy Related Information

N/A

Old Age Related Information

N/A

Breast Feeding Related Information

N/A

Children Related Information

N/A

Indications for Dimethyl polysiloxane

1. Flatulent dyspepsia
2. Postoperative distension
3. Gastric Distention
4. Functional digestive disorders
5. Stomach pain
6. Burning
7. Nausea and excess gas (dyspepsia)

Interactions for Dimethyl polysiloxane

N/A

Typical Dosage for Dimethyl polysiloxane

40 mg tablet to be taken half an hour before food.

Schedule of Dimethyl polysiloxane

N/A

Storage Requirements for Dimethyl polysiloxane

Stored at room temperature (15-30?C) away from moisture and heat.

Effects of Missed Dosage of Dimethyl polysiloxane

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Dimethyl polysiloxane

Give symptomatic and supportive treatment.

Homatropine

About Homatropine

Ophthalmic Anticholinergic alkaloid (Muscarinic antagonist), Mydriatic, cycloplegic.

Mechanism of Action of Homatropine

Homatropine is a muscarinic receptor blocker. It nonselectively inhibits the muscarinic actions of Acetylcholine. Homatropine blocks the muscarinic receptors in the muscles of the eye which are involved in controlling the pupil size and the shape of the lens. It blocks the cholinergic nerves supplying the smooth muscles of iris and produces Mydriasis. It also causes paralysis of ciliary muscle and produces a tightening of the suspensory ligament and results in flattening of the lens and a consequent increase in focal length. Because of paralysis of muscle cannot constrict the pupils for viewing near object or prevents the eye from accommodating for near vision (Cycloplegia). It has less potent antimuscarinic action and short duration of action as compared to Atropine.
Homatropine is given as eye drops to dilate the pupil and relax the lens so that eye examinations can be carried out thoroughly. It is often used to aid eye examinations in young children.

Pharmacokinets of Homatropine

Absorption: Homatropine is readily absorbed after ophthalmic use.

Onset of Action for Homatropine

Rapid

Duration of Action for Homatropine

1 - 3 days

Half Life of Homatropine

N/A

Side Effects of Homatropine

1.Photophobia
2.Irritation
3.Contact dermatitis
4.Blurring of near vision
5.Mydriasis
6.Palpitation
7.Inflammation of the lining of the eye
8.Pain
9.Lacrimation (hyperemia)

Contra-indications of Homatropine

1.Hypersensitivity to Homatropine and other belladonna alkaloids
2.Narrow angle glaucoma

Special Precautions while taking Homatropine

1.Avoid use of soft contact lens
2.Use caution while driving vehicle or operating machine
3.Raised intraocular pressure
4.Stop the use of medicament if any allergic reactions occur

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Use with caution

Indications for Homatropine

1.Dilating the pupil to aid examination of the eye
2.Cycloplegic for use in uveitis and during refraction

Interactions for Homatropine

N/A

Typical Dosage for Homatropine

Homatropine 2% and 5% eye drop is available.
Eye drop: 1 - 2 drop in each eye.
Cycloplegic refraction:
Instill 1 - 2 drop of 2% solution in the eye and repeat if needed in 5 - 10 minutes
Instill 1 drop of 5% solution in the eye and repeat if needed in 5 - 10 minutes
Uveitis: Instill 1 - 2 drop of 2% or 5% solution in the eye and repeat every 3 - 4 hours
Children:
Uveitis: Instill 1 drop of 2% solution in the eye and every 8 - 12 hours

Schedule of Homatropine

N/A

Storage Requirements for Homatropine

Store in a cool dry place in a tightly closed container. Protect from heat and light. Keep out of the reach of children. Discard the drug 1 month after opening.

Effects of Missed Dosage of Homatropine

Instill the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Homatropine

A topical ocular overdose of an ophthalmic product containing Homatropine may be flushed from the eye with warm tap water.

Home Delivery for Tinidazole + Diloxanide Furoate + Dimethyl polysiloxane + Homatropine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including tinidazole + diloxanide furoate + dimethyl polysiloxane + homatropine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for tinidazole + diloxanide furoate + dimethyl polysiloxane + homatropine and other medicines and health products. Home delivery services for tinidazole + diloxanide furoate + dimethyl polysiloxane + homatropine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take tinidazole + diloxanide furoate + dimethyl polysiloxane + homatropine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for tinidazole + diloxanide furoate + dimethyl polysiloxane + homatropine before they complete the sale. You can get this information while placing the order for tinidazole + diloxanide furoate + dimethyl polysiloxane + homatropine with the pharmacy.

Tinidazole + Diloxanide Furoate + Dimethyl polysiloxane + Homatropine is a generic medicine name and there are several brands available for it. Some of the brands for tinidazole + diloxanide furoate + dimethyl polysiloxane + homatropine might be better known than tinidazole + diloxanide furoate + dimethyl polysiloxane + homatropine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tinidazole + diloxanide furoate + dimethyl polysiloxane + homatropine in stock, you can ask for one of the branded alternatives for tinidazole + diloxanide furoate + dimethyl polysiloxane + homatropine.