Ornidazole Pharmacology

Ornidazole

About Ornidazole
A nitro imidazole derivative, Antiprotozoal antibiotic,Antimicrobial.
Mechanism of Action of Ornidazole
Ornidazole is a nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which excerts cytotoxic action by damaging DNA and other critical biomolecules. 3. DNA helix destabilization &strand breakage has been observed.
Pharmacokinets of Ornidazole
Absorption: Well absorbed orally, Distribution: Widely distributed,
Metabolism: Metabolized in liver by conjugation, Excretion: Excreted in urine and small portion is excreted in bile
Onset of Action for Ornidazole
Within 2 hours
Duration of Action for Ornidazole
14hours
Half Life of Ornidazole
12 to 14 hours
Side Effects of Ornidazole
1.Abdominal pain
2.Vertigo
3.Nausea
4.Vomiting
5.Fatigue
6.Dry mouth
7.Headache
8.Rash
9.Urticaria
10.Abdominal distress
11.Dizziness
12.Vertigo
Contra-indications of Ornidazole
1.Hypersensitivity to the drug or other imidazoles
Special Precautions while taking Ornidazole
1.Vertigo
2.Mental confusion
3.Ataxia
Pregnancy Related Information
Use with caution
First trimester: contra indicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
May be used
Children Related Information
Use with caution
Indications for Ornidazole
1.Amoebiasis
2.Giardiasis
3.Trichomonas vaginitis
4.Anaerobic bacterial infections
5.Bacterial vaginosis
Interactions for Ornidazole
N/A
Typical Dosage for Ornidazole
Amoebiasis:
Adults: 1gm daily in 2 divided doses for 7 to 10 days
Children: 10 to 25mg/kg once daily for 3days
Amoebic dysentery:
Adults: 1.5gm once daily for 3 days
Children: 40mg/kg once daily for 3 days
Trichomoniasis
Adults: 1.5gm single daily dose or 0.5gm 12hourly for 5 days,
Male partner should be concurrently treated.
Children: 25mg/kg as a single dose
Giardiasis:
Adults: 1 to 1.5gm once daily for 2days
Children: 40mg/kg for 2days
Bacterial vaginosis: 1.5gm once or 500mg once daily for 5 to7 days
Schedule of Ornidazole
H
Storage Requirements for Ornidazole
Store at cool dry place. Protect from heat and light. Keep out of the reach of children.
Effects of Missed Dosage of Ornidazole
Take the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Ornidazole
Treatment is supportive & symptomatic. Drug is removed by induced emesis, gastric lavage, and administration of activated charcoal &use of cathartics.

Home Delivery for Ornidazole in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ornidazole.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ornidazole and other medicines and health products. Home delivery services for ornidazole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take ornidazole only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ornidazole before they complete the sale. You can get this information while placing the order for ornidazole with the pharmacy.

Ornidazole is a generic medicine name and there are several brands available for it. Some of the brands for ornidazole might be better known than ornidazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ornidazole in stock, you can ask for one of the branded alternatives for ornidazole.