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- Pharmacology For Rifampicin + Isoniazid + Ethambutol
Rifampicin + Isoniazid + Ethambutol Pharmacology
Rifampicin + Isoniazid + Ethambutol
About Rifampicin + Isoniazid + EthambutolN/AMechanism of Action of Rifampicin + Isoniazid + EthambutolN/APharmacokinets of Rifampicin + Isoniazid + EthambutolN/AOnset of Action for Rifampicin + Isoniazid + EthambutolN/ADuration of Action for Rifampicin + Isoniazid + EthambutolN/AHalf Life of Rifampicin + Isoniazid + EthambutolN/ASide Effects of Rifampicin + Isoniazid + EthambutolN/AContra-indications of Rifampicin + Isoniazid + EthambutolN/ASpecial Precautions while taking Rifampicin + Isoniazid + EthambutolN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Rifampicin + Isoniazid + EthambutolN/AInteractions for Rifampicin + Isoniazid + EthambutolN/ATypical Dosage for Rifampicin + Isoniazid + EthambutolN/ASchedule of Rifampicin + Isoniazid + EthambutolN/AStorage Requirements for Rifampicin + Isoniazid + EthambutolN/AEffects of Missed Dosage of Rifampicin + Isoniazid + EthambutolN/AEffects of Overdose of Rifampicin + Isoniazid + EthambutolN/ARifampicin
About RifampicinRifamycin derivative, Antituberculosis antibiotic.Mechanism of Action of RifampicinRifampicin is primarily bactericidal and has some bacteriostatic properties also. It acts by inhibiting DNA dependent RNA polymerase and thus stopping the expression of bacterial genes.M.tuberculosis requires DNA dependent RNA polymerase enzyme for the synthesis of RNA and protein. Without this enzyme bacteria cannot reproduce and they die.
Pharmacokinets of RifampicinAbsorption: Well absorbed orally, Distribution: Widely distributed, Metabolism: Metabolized in liver in to active desacetyl Rifampicin Excretion: Excreted mainly in bile & some extend in urineOnset of Action for RifampicinN/ADuration of Action for Rifampicin24 hoursHalf Life of Rifampicin2 - 5 hourSide Effects of Rifampicin1. Nausea
2. Vomiting
3. Epigastric distress
4. Anorexia
5. Pseudo membranous colitis
6. Acute renal failure
7. Hepato toxicity
8. Eosinophilia
9. Thrombocytopenia
10. Urticaria
11. Rash
12. Pruritis
13. Purpura
14. Shock
15. Headache
16. Drowsiness
17. Visual disturbance
18. Thrombophlebitis
19. Menstrual problems
Contra-indications of Rifampicin1.Hypersensitivity to the drug
2.Hepatic impairment
3.Jaundice
4.Biliary obstruction
5.Porphyria
6.As I.M. or S.C. injection
Special Precautions while taking RifampicinRenal impairment:
Use with caution
Hepatic impairment:
Use with caution
Other precautions:
1.Use with caution in alcoholics
2.Use with caution in malnourished individuals
3.Stop the drug use in Purpura & Thrombocytopenia
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationAbove 5 years: May be used
Neonates: Contraindicated
Indications for Rifampicin1. Leprosy
2. Tuberculosis
3. Prophylaxis of meningococcal carriers
4. Prophylaxis of H. influenzae
Interactions for RifampicinRifampicin by inducing the hepatic microsomal enzymes may reduce the efficacy of the following drugs: Acetaminophen, oral anticoagulants, barbiturates, benzodiazepines, chloramphenicol, clofibrate. Oral contraceptives, corticosteroids, cyclosporine, digitoxin, disopyramide, beta blockers oestrogens, hydantoins, mexiletine, quinidine, sulfones, sulphonylureas, theophylline, verapamil.
Halothane: Hepatotoxicity and hepatic encephalopathy.
Isoniazid: Higher incidence of hepatotoxicity than with either agent alone.
Ketoconazole: Treatment failure of either ketoconazole or rifampicin.
Food: Interferes with absorption of rifampicin, therefore it should be taken on empty stomach.
Lab tests: Inhibits standard assays for serum folate and vitamin B12 (riboflavin). Transient abnormalities in liver function tests, reduced excretion of contrast media used for visualization of gall bladder.
Typical Dosage for RifampicinAdults: 0.45gm to 0.6gm single dose
Children: 10 to 20 mg/kg/day
Leprosy: 600mg orally once monthly
Pulmonary tuberculosis:
Adults: 600mg/day orally or I.V. as a single dose
Children: 10 to 20 mg/kg/day orally or I.V.as a single dose
Meningococcal infections:
600mg 12 hourly for two days
Children (1 to 2 years): 10 mg/kg
Children (below 1 year): 5mg/kg for two days
Schedule of RifampicinHStorage Requirements for RifampicinStore in a cool dry place.Protect from heat and light.Keep out of the reach of children.Effects of Missed Dosage of RifampicinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of RifampicinTreatment includes Gastric lavage, administration of activated charcoal, forced diuresis & bile drainage etc.Isoniazid
About IsoniazidHydrazine derivative, Antitubercular Agent.Mechanism of Action of IsoniazidIsoniazid is a bactericidal drug. I t inhibits the mycolic acid synthesis which is essential for the cell wall formation. It also inhibits DNA, RNA and protein synthesis and cell metabolism. As the results of these bacterial death occurs.Pharmacokinets of IsoniazidAbsorption: It is rapidly absorbed after oral administration.Distribution: It is very widely distributed in the body.Metabolism: It undergoes metabolism in the liver.Excretion:It is mainly excreted through urine and small amount excreted through bile, breast milk, sputum and saliva.Onset of Action for Isoniazid1 - 2 daysDuration of Action for Isoniazid1 dayHalf Life of Isoniazid1 - 4 hourSide Effects of Isoniazid1. Nausea
2 .Vomiting
3. Gastric upset
4. Peripheral neuritis
5. Optic neuritis
6. Atrophy
7. Paresthesia
8. Allergy
9. Fever
10.Rash
11.Malaise
12.Lymph adenopathy
13.JaundiceContra-indications of Isoniazid1. Hypersensitivity to Isoniazide
2. Drug induced hepatic diseaseSpecial Precautions while taking Isoniazid1.Renal impairment
2.Hepatic impairment
3.Alcoholism
4.EpilepsyPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with caution
Children Related InformationMay be used
NEONATES: may be used
Indications for Isoniazid1.Tuberculosis (pulmonary &extra pulmonary)Interactions for IsoniazidAlcohol: Regular ingestion of alcohol is associated with higher incidence of INH-related hepatitis.
Aluminium Salts: Oral absorption of INH reduced leading to decreased serum levels.
Oral anticoagulants: Efficacy of oral anticoagulants increased.
Benzodiazepines: Activity of benzodiazepines that undergo oxidative metabolism is possibly increased.
Carbamazepine: Isoniazid hepatotoxicity & carbamazepine toxicity may occur from concurrent use.
Cycloserine: Increased cycloserine related CNS side effects, especially dizziness.
Disulfiram: Acute behavioural and co-ordination changes.
Enflurane: High output renal failure may occur.
Halothane: Hepatotoxicity and hepatic encephalopathy.
Hydantoins: Serum hydantoin levels increased leading to enhanced pharmacological and toxic effects.
Ketoconazole: Serum concentrations of ketoconazole decreased possibly leading to resistance to antifungal treatment.
Rifampicin: Higher incidence of hepatotoxicity than with either agent alone.
Food: Interaction with tyramine-containing foods since INH has MAOI activity.
Exaggerated response (headache, palpitation, sweating, hypotension, flushing, itching) to foods containing histamine (tuna, sauerkraut juice, yeast extract).
Typical Dosage for IsoniazidAdult: 200 - 300 mg once daily for 6 months to 24 months depending on the severity of infection
Children:5 - 10 mg / kg body weight / day for 6 months to 24 months depending on the severity of infection.
Schedule of IsoniazidHStorage Requirements for IsoniazidThe drug should be stored at room temperature .Keep away from heat, light and moisture. The vial should be kept at 2 - 8 degree Celsius.Effects of Missed Dosage of IsoniazidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Continue the regular schedule.Do not double the dose.Effects of Overdose of IsoniazidGive supportive measures and treatment. Control seizure by giving Diazepam. Then Pyridoxine is administered followed by gastric lavage. Acidosis can be treated with sodium bicarbonate by parenteral administration. Forced diuresis and dialysis can be done if necessary.Ethambutol
About EthambutolEthylenediamine derivative, Antitubercular Agent(Cell envelope antibiotic).Mechanism of Action of EthambutolEthambutol is a bacteriostatic drug.It inhibits arabinogalactan synthesis and interfere mycolic acid incorporation in to the cell wall.Pharmacokinets of EthambutolAbsorption: About 70 % of the drug is rapidly absorbed after oral administration.Distribution: It is very widely distributed in the body.Metabolism: It undergoes metabolism in the liver.Excretion:It is excreted mainly through urine and also bile and breast milk.Onset of Action for EthambutolN/ADuration of Action for Ethambutol1 dayHalf Life of Ethambutol3 - 4 hourSide Effects of Ethambutol1. Optic neuritis
2. Nausea
3. Vomiting
4. Abdominal pain
5. Gastric upset
6. Headache
7. Loss of colour vision
8. Dizziness
9. Mental confusion
10. Hallucination
11. Peripheral neuritis
12. Anaphylactoid reaction
13. Dermatitis
14. Pruritis
15. Thrombocytopenia
16. MalaiseContra-indications of Ethambutol1. Optic neuritis
2. Hypersensitivity to Ethambutol
3. Children below 13 yearsSpecial Precautions while taking Ethambutol1. Renal impairment
2. Diabetic retinopathy
3. Eye inflammation
4. Gout
5. CataractPregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related Informationcontraindicated in children below 13 year
NEONATES: contraindicated
Indications for EthambutolPulmonary tuberculosis in category 1 & 2 patientsInteractions for EthambutolAluminium salts: Absorption of ethambutol may be delayed or reduced.Typical Dosage for EthambutolAdult: 15 - 25 mg / kg/ body weight/day depending on the condition of the disease state
Children (above 13 year): 15 - 25 mg / kg/ body weight/day depending on the condition of the disease state.
Schedule of EthambutolHStorage Requirements for EthambutolEthambutol should be kept in a tightly closed container at room temperature. Keep away from heat and moisture.Effects of Missed Dosage of EthambutolTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.Effects of Overdose of EthambutolGive supportive measures and treatment. Induce emesis or gastric lavage followed with charcoal administration.Home Delivery for Rifampicin + Isoniazid + Ethambutol in Your City
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Rifampicin + Isoniazid + Ethambutol is a generic medicine name and there are several brands available for it. Some of the brands for rifampicin + isoniazid + ethambutol might be better known than rifampicin + isoniazid + ethambutol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have rifampicin + isoniazid + ethambutol in stock, you can ask for one of the branded alternatives for rifampicin + isoniazid + ethambutol.