Tetracycline Pharmacology
Tetracycline
2.Aggravates renal & hepatic impairment
3.Nausea
4.Vomiting
5.Epigastric distress
6.Super infection
7.Skin rashes
8.Arrhythmia, Cardiac arrest
9.Neutropenia, Thrombocytopenia
10.Elevated liver enzymes
11.Discoloration of teeth & Retardation of bone growth
12.Esophageal ulceration
1.Tetracycline aggravates renal impairment & leads to negative nitrogen balance. So avoid use of drug in renal impairment.
Hepatic impairment:
High dose causes hepato toxicity, so dose adjustments is required & avoid
Other precautions:
1.Avoid use together with milk & milk products, Antacids, Cations, Vitamins, Products which contain divalent or trivalent cations
2.Potentiation of action of anticoagulants; so avoid use together
3.Diabetes mellitus, Hyperthyroidism, & Hypertensions
Neonates: Contraindicated
2. Chlamydia infections
3. Rickettsial infections
4. Cholera
5. Brucellosis
6. Sexually transmitted diseases like syphilis, gonorrhea, Chancroid
7. Urinary tract infections
8. H-pylori infection
9. Acne
10. Lyme disease
11. Malaria
Anticoagulants: Increase the hypothrombinemic effects of anti-coagulants.
Cimetidine: Decreases GI absorption leading to decreased efficacy of tetracyclines.
Digoxin: Increased serum levels leading to digoxin toxicity.
Methoxyflurane: Nephrotoxic effects of both increased.
Oral contraceptives: Breakthrough bleeding, pregnancy due to decreased efficacy.
Penicillins: Efficacy reduced.
Food: Dairy products decrease efficacy of tetracyclines.
Lab tests: Bacterio-suppressive levels of Demeclocycline persist in both urine and blood for several days after cessation of therapy interfering with culture studies.
Children: 15 to 25mg/kg bodyweight. Maximum dose 50mg/kg. Administer 6hourly or 12 hourly as required
Infections of cervix, urethra&rectum caused by Chlamydia trachomatis:2gm daily; orally; in four divided doses for a week.
Gonorrhea: Starts with 1.5gm oral administration & then administer 500mg tablets four times daily for four days
Syphilis: oral administration of 1-2 gm daily in four divided doses for two weeks
Brucellosis: 2gm daily in four divided doses for 28 days (along with streptomycin 1gm for first 21 days)
Ulcer caused by H-pylori infection: 2gm daily in four divided doses for 10 - 14 days.
Lyme disease: 0.25-0.5gm; orally four times daily for 10 days to One month.
Acne: Initial dose-0.5gm to 1gm orally four times daily; maintenance dose 0.12 to 0.5mg daily
Malaria: 1 g daily in 2 - 4 divided doses
Home Delivery for Tetracycline in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including tetracycline.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for tetracycline and other medicines and health products. Home delivery services for tetracycline may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take tetracycline only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for tetracycline before they complete the sale. You can get this information while placing the order for tetracycline with the pharmacy.
Tetracycline is a generic medicine name and there are several brands available for it. Some of the brands for tetracycline might be better known than tetracycline itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tetracycline in stock, you can ask for one of the branded alternatives for tetracycline.