Gemifloxacin Pharmacology

Gemifloxacin

About Gemifloxacin

Fourth-generation Fluoroquinolone(Respiratory) antibacterial, oral broad-spectrum Fluoroquinolone antibiotic.

Mechanism of Action of Gemifloxacin

Gemifloxacin act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Gemifloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.

Pharmacokinets of Gemifloxacin

Absorption: Gemifloxacin is rapidly absorbed after oral administration. Distribution:It is widely distributed in the body mostly in protein bound form. Metabolism: Only a very small amount of drug undergoes metabolism in the liver. Excretion: Drug and its metabolites are excreted mainly in faeces and small amount in urine.

Onset of Action for Gemifloxacin

N/A

Duration of Action for Gemifloxacin

N/A

Half Life of Gemifloxacin

4 - 12 hours

Side Effects of Gemifloxacin

1.Diarrhea
2.Vomiting
3.Nausea
4.Headache
5.Abdominal pain
6.Rash
7.Dizziness
8.Abdominal pain
9.Anorexia
10.Constipation
11.Dermatitis
12.Dry mouth
13.Dyspepsia
14.Fatigue
15.Flatulence
16.Gastritis

Contra-indications of Gemifloxacin

Hypersensitivity to Gemifloxacin and other Fluoroquinolones

Special Precautions while taking Gemifloxacin

1.Hepatic impairment
2.Rash

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Contraindicated

Indications for Gemifloxacin

1.Bronchitis
2.Pneumonia
3.Influenzae

Interactions for Gemifloxacin

N/A

Typical Dosage for Gemifloxacin

Oral:
Adult: 320mg once daily for 5 to 7 days depending on the severity of infection.

Schedule of Gemifloxacin

N/A

Storage Requirements for Gemifloxacin

Store the medicine at 15 - 30 degree Celsius. Protect from heat and moisture. Keep out of the reach of children.

Effects of Missed Dosage of Gemifloxacin

Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose and do not double the dose

Effects of Overdose of Gemifloxacin

Give supportive measures and symptomatic treatment. Drug can be removed by inducing vomiting or by gastric lavage.

Home Delivery for Gemifloxacin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including gemifloxacin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for gemifloxacin and other medicines and health products. Home delivery services for gemifloxacin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take gemifloxacin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for gemifloxacin before they complete the sale. You can get this information while placing the order for gemifloxacin with the pharmacy.

Gemifloxacin is a generic medicine name and there are several brands available for it. Some of the brands for gemifloxacin might be better known than gemifloxacin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have gemifloxacin in stock, you can ask for one of the branded alternatives for gemifloxacin.