Esomeprazole + Itopride Pharmacology

Esomeprazole + Itopride

About Esomeprazole + Itopride
N/A
Mechanism of Action of Esomeprazole + Itopride
N/A
Pharmacokinets of Esomeprazole + Itopride
N/A
Onset of Action for Esomeprazole + Itopride
N/A
Duration of Action for Esomeprazole + Itopride
N/A
Half Life of Esomeprazole + Itopride
N/A
Side Effects of Esomeprazole + Itopride
N/A
Contra-indications of Esomeprazole + Itopride
N/A
Special Precautions while taking Esomeprazole + Itopride
N/A
Pregnancy Related Information
Contraindicated
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated
Children Related Information
N/A
Indications for Esomeprazole + Itopride
Treatment of gastrooesophagel reflux disease without oesophagitis including erosions ulcerations.
Interactions for Esomeprazole + Itopride
N/A
Typical Dosage for Esomeprazole + Itopride
N/A
Schedule of Esomeprazole + Itopride
N/A
Storage Requirements for Esomeprazole + Itopride
N/A
Effects of Missed Dosage of Esomeprazole + Itopride
N/A
Effects of Overdose of Esomeprazole + Itopride
N/A

Esomeprazole

About Esomeprazole
A proton pump inhibitor, Substituted Benzimidazole, Antiulcer, antisecretory drug.
Mechanism of Action of Esomeprazole
Esomeprazole is the S enantiomer of Omeprazole and is a proton pump inhibitor. It is a prodrug. After administration it diffuses in to the parietal cell of the stomach and accumulates in the secretory canaliculi. In the acidic medium Esomeprazole is converted to sulfenamide. This sulfenamide covalently interacts with sulfhydryl (SH) group in the proton pump (H+ K+ATPase) and inhibits the exchange of extracellular K+ for intracellular H+ ion. Esomeprazole irreversibly inhibits proton pumps activity and decreases gastric acid secretion. As compared to Omeprazole, Esomeprazole produces better control of intragastric acidity in Gastroesophageal reflux diseases. It is as effective as Omeprazole in other disease condition.
Pharmacokinets of Esomeprazole
Absorption: Esomeprazole is well absorbed after oral administration. Distribution: It is widely distributed in the body in protein bound form. Metabolism: Esomeprazole is extensively metabolised in the liver. Excretion: It is excreted mainly in the urine and small amount in faeces.
Onset of Action for Esomeprazole
Rapid
Duration of Action for Esomeprazole
Prolonged
Half Life of Esomeprazole
60- 90 minutes
Side Effects of Esomeprazole
1.Diarrhoea
2.Nausea
3.Abdominal pain
4.Constipation
5.Headache
6.Flatulence
7.Dry mouth
Contra-indications of Esomeprazole
1.Gastric ulcer
2.Gastroesophageal reflux disease
3.Oesophagitis
4.NSAID associated ulceration
5.Duodenal ulcer related to H. pylori infection
Special Precautions while taking Esomeprazole
1.Hepatic impairment
2.Monitor gastric malignancy
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Esomeprazole
1.Gastric ulcer
2.Gastroesophageal reflux disease
3.Oesophagitis
4.NSAID associated ulceration
5.Duodenal ulcer related to H. pylori infection
Interactions for Esomeprazole
Esomeprazole may potentially interfere with CYP2Cl9, the major esomeprazole metabolizing enzyme.
Esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (e.g., ketoconazole, iron salts and digoxin). Esomeprazole does not have any clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin or amoxycillin.

Typical Dosage for Esomeprazole
Gastro-oesophageal Reflux Disease (GORD): Healing of erosive oesophagitis: 20mg or 40mg once daily for 4 to 8 weeks.
Maintenance of healing of erosive esophagitis: 20mg once daily.
Symptomatic gastroesophageal reflux disease: 20mg once daily for 4 weeks.
H. pylori eradication to reduce the risk of duodenal ulcer recurrence
Esomeprazole: 40mg, once daily for 10 days along with Amoxycillin and Clarithromycin



Schedule of Esomeprazole
H
Storage Requirements for Esomeprazole
Store at 15 - 30 degree C in a tightly closed container. Protect from light.
Effects of Missed Dosage of Esomeprazole
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Esomeprazole
Give supportive measures and symptomatic treatment.

Itopride

About Itopride
Dopamine(D2) antagonist, a prokinetic benzamide derivative, Motility stimulant.
Mechanism of Action of Itopride
Itopride has three way action. It inhibits the dopamine D2 receptor at the parasympathetic nerve ends.It increases the release of acetycholine and decreases the metabolism of acetylcholine by inhibiting the enzyme acetylcholinesterase (AChE). By maintaining higher acetylcholine levels, itopride increases the oesophageal and gastrointestinal peristalsis, increases the lower oesophageal sphincter pressure, stimulates gastric motility, accelerates gastric emptying and improves gastro-duodenal coordination. Itopride exerts anti-emetic actions because of its dopamine D2 receptor antagonistic action at CTZ.
Pharmacokinets of Itopride
Absorption: it is orally well absorbed after oral administration.Metabolism: Itopride undergoes extensive hepatic metabolism.

Onset of Action for Itopride
N/A
Duration of Action for Itopride
N/A
Half Life of Itopride
5 - 6 hours
Side Effects of Itopride
1.Diarrhoea
2.Abdominal pain
3.Headache
4.Constipation
5.Irritated feeling
6.Giddiness
Contra-indications of Itopride
1.Hypersensitivity to Itopride
2.Gastrointestinal haemorrhage
3.Mechanical obstruction or perforation
Special Precautions while taking Itopride
N/A
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Below12 years: Contraindicated

Indications for Itopride
1.Gastro oesophageal reflux diseases
2.Diabetic Gastroparesis
3.Non ulcer dyspepsia
4.Chronic gastritis

Interactions for Itopride
Cisapride, atropine.
Typical Dosage for Itopride
Adult-Oral: 50 mg 3 times daily taken before each meal
Schedule of Itopride
N/A
Storage Requirements for Itopride
Store the drug below 30 degree C. Protect from heat and light.
Effects of Missed Dosage of Itopride
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Itopride
Give supportive measures and symptomatic treatment.

Home Delivery for Esomeprazole + Itopride in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for esomeprazole + itopride and other medicines and health products. Home delivery services for esomeprazole + itopride may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take esomeprazole + itopride only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for esomeprazole + itopride before they complete the sale. You can get this information while placing the order for esomeprazole + itopride with the pharmacy.

Esomeprazole + Itopride is a generic medicine name and there are several brands available for it. Some of the brands for esomeprazole + itopride might be better known than esomeprazole + itopride itself. If the pharmacy that's willing to deliver medicines to your home doesn't have esomeprazole + itopride in stock, you can ask for one of the branded alternatives for esomeprazole + itopride.