Alpha-Lipoic Acid + Vit B12 + Omega 3 Fatty Acid + Chromium + Selenium Pharmacology

Alpha-Lipoic Acid + Vit B12 + Omega 3 Fatty Acid + Chromium + Selenium

About Alpha-Lipoic Acid + Vit B12 + Omega 3 Fatty Acid + Chromium + Selenium

N/A

Mechanism of Action of Alpha-Lipoic Acid + Vit B12 + Omega 3 Fatty Acid + Chromium + Selenium

N/A

Pharmacokinets of Alpha-Lipoic Acid + Vit B12 + Omega 3 Fatty Acid + Chromium + Selenium

N/A

Onset of Action for Alpha-Lipoic Acid + Vit B12 + Omega 3 Fatty Acid + Chromium + Selenium

N/A

Duration of Action for Alpha-Lipoic Acid + Vit B12 + Omega 3 Fatty Acid + Chromium + Selenium

N/A

Half Life of Alpha-Lipoic Acid + Vit B12 + Omega 3 Fatty Acid + Chromium + Selenium

N/A

Side Effects of Alpha-Lipoic Acid + Vit B12 + Omega 3 Fatty Acid + Chromium + Selenium

N/A

Contra-indications of Alpha-Lipoic Acid + Vit B12 + Omega 3 Fatty Acid + Chromium + Selenium

N/A

Special Precautions while taking Alpha-Lipoic Acid + Vit B12 + Omega 3 Fatty Acid + Chromium + Selenium

N/A

Pregnancy Related Information

Use with caution

Old Age Related Information

N/A

Breast Feeding Related Information

Use with caution

Children Related Information

N/A

Indications for Alpha-Lipoic Acid + Vit B12 + Omega 3 Fatty Acid + Chromium + Selenium

1.Diabetic Neuropathy and other associated problems
2.Cardio Protective
3.Nutritional supplement
4.Antioxidant

Interactions for Alpha-Lipoic Acid + Vit B12 + Omega 3 Fatty Acid + Chromium + Selenium

N/A

Typical Dosage for Alpha-Lipoic Acid + Vit B12 + Omega 3 Fatty Acid + Chromium + Selenium

N/A

Schedule of Alpha-Lipoic Acid + Vit B12 + Omega 3 Fatty Acid + Chromium + Selenium

N/A

Storage Requirements for Alpha-Lipoic Acid + Vit B12 + Omega 3 Fatty Acid + Chromium + Selenium

N/A

Effects of Missed Dosage of Alpha-Lipoic Acid + Vit B12 + Omega 3 Fatty Acid + Chromium + Selenium

N/A

Effects of Overdose of Alpha-Lipoic Acid + Vit B12 + Omega 3 Fatty Acid + Chromium + Selenium

N/A

Alpha-Lipoic acid

About Alpha-Lipoic acid

Naturally occurring dithiol compound , antioxidant, Agent for neuropathies.

Mechanism of Action of Alpha-Lipoic acid

Alpha-lipoic acid and its reduced metabolite, Dihydrolipoic acid (DHLA), form a redox couple and may scavenge a wide range of reactive oxygen species. Alpha-lipoic acid has been found to decrease urinary isoprostanes, O-LDL and plasma protein carbonyls, markers of oxidative stress. Further, alpha-lipoic acid and its redox couple DHLA have been found to have antioxidant activity in aqueous, as well as in lipophilic regions, and in extra cellular and intracellular environments. Alpha-lipoic acid participates in the recycling of other important biologic antioxidants, such as vitamins E and C, Ubiquinone and glutathione.
Both alpha-lipoic acid and DHLA can scavenge hydroxyl radicals, the nitric oxide radical, peroxynitrite, hydrogen peroxide and hypochlorite. Alpha-lipoic acid may scavenge singlet oxygen, and DHLA may scavenge super oxide and peroxyl reactive oxygen species.

Pharmacokinets of Alpha-Lipoic acid

Absorption: Alpha-lipoic acid is absorbed from the small intestine. The natural R-entantiomer is more readily absorbed than the L-entantiomer and is the more active form.
Distribution:It is distributed to the liver via the portal circulation and to various tissues in the body via the systemic circulation. . Alpha-lipoic acid readily crosses the blood-brain barrier. It is found, after its distribution to the various body tissues, intracellularly, intramitochondrialy and extracellularly.Metabolism: Alpha-lipoic acid is metabolized to its reduced form, dihydrolipoic acid (DHLA), by mitochondrial lipoamide dehydrogenase enzyme. DHLA, together with lipoic acid, form a redox couple. It is also metabolized to lipoamide, which functions as the lipoic acid cofactor in the multienzyme complexes that catalyze the oxidative decarboxylations of pyruvate and alpha-ketoglutarate. Alpha-lipoic acid may be metabolized to dithiol octanoic acid, which can undergo catabolism.

Onset of Action for Alpha-Lipoic acid

N/A

Duration of Action for Alpha-Lipoic acid

N/A

Half Life of Alpha-Lipoic acid

N/A

Side Effects of Alpha-Lipoic acid

1.Nausea
2.Vomiting

Contra-indications of Alpha-Lipoic acid

1.Contraindicated during radiotherapy

Special Precautions while taking Alpha-Lipoic acid

Patient with diabetes and problems with glucose intolerance

Pregnancy Related Information

Use with caution

Old Age Related Information

N/A

Breast Feeding Related Information

Use with caution

Children Related Information

N/A

Indications for Alpha-Lipoic acid

1.Diabetic neuropathy
2.It may help prevent the oxidation of LDL cholesterol and may be protective, generally, against oxidative stress and, specifically, against atherosclerosis, ischemia-reperfusion injury and various radiologic and chemical toxins.
3.It may also be useful in some inborn metabolic disorders

Interactions for Alpha-Lipoic acid

N/A

Typical Dosage for Alpha-Lipoic acid

Adult: up to 600 milligrams daily
Diabetic neuropathy: 300 milligrams daily taken in divided doses.

Schedule of Alpha-Lipoic acid

N/A

Storage Requirements for Alpha-Lipoic acid

Store at room temperature away from moisture and heat.Keep out of the reach of children. Keep the medicine from freezing. Do not refrigerate.

Effects of Missed Dosage of Alpha-Lipoic acid

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Continue the regular schedule.Do not double the dose.

Effects of Overdose of Alpha-Lipoic acid

Give supportive measures and symptomatic treatment.

Vit B12

About Vit B12

N/A

Mechanism of Action of Vit B12

Vitamin B12 is an essential constituent for growth, cell reproduction, hematopoiesis, and nucleoprotein and myelin synthesis. Vitamin B12 is converted in to coenzyme B12 in the tissues which is essential for conversion of methyl-malonate to succinate and synthesis of methionine from homocystine. It is also associated with fat and carbohydrate metabolism and protein synthesis. Cells characterized by rapid division such as epithelial cells, bone marrow, and myeloid cells appear to have greatest requirement of Cyanocobalamin.

Pharmacokinets of Vit B12

Absorption: Absorbed irregularly after oral administration and absorption depends on Ca and intrinsic factor. It is also administered subcutaneously and intramuscularly.
Distribution: Distributed in to liver, bone marrow, and other tissues. It crosses the placenta and appears in breast milk.
Metabolism: It is metabolized in liver.
Excretion: In normal dosage it is reabsorbed from bile and a minute portion is excreted through urine but the extra drug is excreted through urine.

Onset of Action for Vit B12

N/A

Duration of Action for Vit B12

N/A

Half Life of Vit B12

N/A

Side Effects of Vit B12

1. Anaphylaxis
2. Anaphylactoid reactions
3. Pain and burning sensation at injection site
4. Itching
5. Urticaria
6. Transient diarrhea
7. Peripheral vascular thrombosis
8. Pulmonary oedema

Contra-indications of Vit B12

1. Hypersensitivity to the drug
2. Leber`s disease

Special Precautions while taking Vit B12

1. Anemic patients with coexisting cardiac, pulmonary and hypertensive diseases.

Pregnancy Related Information

May be used

Old Age Related Information

May be used

Breast Feeding Related Information

May be used

Children Related Information

Use with caution
NEONATES : Use with caution

Indications for Vit B12

1. Vitamin B12 deficiency
2. Pernicious Anaemia
3. Peripheral neuropathy (diabetic, alcoholic, and drug induced)

Interactions for Vit B12

N/A

Typical Dosage for Vit B12

I.M., S.C.:
Pernicious Anaemia: 100mcg daily for 1 week followed by the same dose given on alternate days for 7 doses and then every 3 to 4days for another 3 weeks. This regimen should be followed by 100mcg monthly for life. Concurrently administer folic acid if required.
Vitamin B12 deficiency other than pernicious Anaemia: 30mcg daily for 5 to 10days depending up on the severity of the condition.
Maintenance dosage: 100 to 200mcg once monthly.
Children: 100mcg I.M. or S.C. over the course of 2 or more weeks.
Maintenance dosage: 60mcg monthly I.M. or S.C.
Schilling test flushing dose:
Adults and Children: 1000mcg I.M. in single dose
Recommended RDA (recommended dietary allowance) for Vitamin B12:
Infants up to 6months of age: 0.3mcg.
Children age 6 months to 1 year: 0.5mcg.
Children age 1 to 3: 0.7mcg.
Children age 4 to 6: 1mcg.
Children age 7 to 10: 1.4mcg.
Children age 11 to adult: 2mcg..
Pregnant women: 2.2mcg.
Breast feeding women: 2.6mcg.

Schedule of Vit B12

Storage Requirements for Vit B12

Store at room temperature range of 15 to 30 degree C.in a light resistant well closed container in a dry place.

Effects of Missed Dosage of Vit B12

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Vit B12

Not applicable. Even in large doses Vitamin B12 isn`t usually toxic.

About

N/A

Mechanism of Action of

N/A

Pharmacokinets of

N/A

Onset of Action for

N/A

Duration of Action for

N/A

Half Life of

N/A

Side Effects of

N/A

Contra-indications of

N/A

Special Precautions while taking

N/A

Pregnancy Related Information

N/A

Old Age Related Information

N/A

Breast Feeding Related Information

N/A

Children Related Information

N/A

Indications for

N/A

Interactions for

N/A

Typical Dosage for

N/A

Schedule of

N/A

Storage Requirements for

N/A

Effects of Missed Dosage of

N/A

Effects of Overdose of

N/A

Chromium

About Chromium

Chromium is by far the most pivotal nutrient involved in sugar metabolism. Trivalent chromium is a part of glucose tolerance factor, an essential activator of insulin mediated reactions. Chromium improves insulin binding, insulin receptor number, insulin internalization, beta cell sensitivity and insulin receptor enzymes with overall increases in insulin sensitivity. Thus it helps to maintain normal glucose metabolism and peripheral nerve function. A number of clinical studies have been conducted which show that chromium is an effective therapy for both Type I and Type II diabetes. Except for supplementation, there is no good way to rebuild the body?s stockpile of chromium.
Deficiency symptoms: Impaired glucose tolerance, peripheral neuropathy, ataxia, confusion.
Over dosage symptoms: In normal therapeutic doses side effects have not been reported except occasional insomnia. In the event of over dosage - nausea, vomiting, GI ulcers, renal/hepatic damage, convulsion, coma may occur.

Mechanism of Action of Chromium

Chromium picolinate acts by influencing carbohydrate metabolism. It stimulates Insulin mediated reactions and improves glucose tolerance. Chromium picolinate helps to improve; insulin binding, insulin receptor number, insulin internalization, beta cell sensitivity and insulin receptor enzymes with overall increase in insulin sensitivity. Thus it maintains normal glucose metabolism and peripheral nerve functions. It improves carbohydrate metabolism, increases energy and helps to control diabetes. It also helps to control weight.

Pharmacokinets of Chromium

Absorption: Well absorbed orally, Distribution: Widely distributed in the body in especially in to liver, kidney, bone, and spleen; normal plasma level is 1 to 5mcg/l. Excretion: Excreted mainly through urine.

Onset of Action for Chromium

N/A

Duration of Action for Chromium

N/A

Half Life of Chromium

N/A

Side Effects of Chromium

N/A

Contra-indications of Chromium

1. Hypersensitivity to the drug.

Special Precautions while taking Chromium

1. Prolonged therapy with the drug
2.Hypoglycaemia
3.In patients with Type II diabetes mellitus use of chromium picolinate is only under the direct medical supervision
4.Renal impairment
5.Hepatic impairment

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

N/A

Indications for Chromium

1.Type I diabetes mellitus
2.Type II diabetes mellitus
3.Obesity.

Interactions for Chromium

N/A

Typical Dosage for Chromium

Oral: 200 mcg daily; increases up to 1mg daily if required.

Schedule of Chromium

N/A

Storage Requirements for Chromium

Store in a well closed container at a cool dry place.

Effects of Missed Dosage of Chromium

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Chromium

Give supportive measures and symptomatic treatment.

Selenium

About Selenium

A vital antioxidant, selenium acts with vitamin E to protect the immune system and maintain healthy heart function. It is needed for pancreatic function and tissue elasticity and has been shown to protect against radiation and toxic minerals. High levels of heart disease are associated with selenium-deficient soil in Finland and a tendency to fibrotic heart lesions is associated with selenium deficiency in parts of China. Best sources are butter, Brazil nuts, seafood and grains grown in selenium-rich soil.

Mechanism of Action of Selenium

N/A

Pharmacokinets of Selenium

N/A

Onset of Action for Selenium

N/A

Duration of Action for Selenium

N/A

Half Life of Selenium

N/A

Side Effects of Selenium

N/A

Contra-indications of Selenium

N/A

Special Precautions while taking Selenium

N/A

Pregnancy Related Information

N/A

Old Age Related Information

N/A

Breast Feeding Related Information

N/A

Children Related Information

N/A

Indications for Selenium

N/A

Interactions for Selenium

N/A

Typical Dosage for Selenium

N/A

Schedule of Selenium

N/A

Storage Requirements for Selenium

N/A

Effects of Missed Dosage of Selenium

N/A

Effects of Overdose of Selenium

N/A

Home Delivery for Alpha-Lipoic Acid + Vit B12 + Omega 3 Fatty Acid + Chromium + Selenium in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including alpha-lipoic acid + vit b12 + omega 3 fatty acid + chromium + selenium.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for alpha-lipoic acid + vit b12 + omega 3 fatty acid + chromium + selenium and other medicines and health products. Home delivery services for alpha-lipoic acid + vit b12 + omega 3 fatty acid + chromium + selenium may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take alpha-lipoic acid + vit b12 + omega 3 fatty acid + chromium + selenium only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for alpha-lipoic acid + vit b12 + omega 3 fatty acid + chromium + selenium before they complete the sale. You can get this information while placing the order for alpha-lipoic acid + vit b12 + omega 3 fatty acid + chromium + selenium with the pharmacy.

Alpha-Lipoic Acid + Vit B12 + Omega 3 Fatty Acid + Chromium + Selenium is a generic medicine name and there are several brands available for it. Some of the brands for alpha-lipoic acid + vit b12 + omega 3 fatty acid + chromium + selenium might be better known than alpha-lipoic acid + vit b12 + omega 3 fatty acid + chromium + selenium itself. If the pharmacy that's willing to deliver medicines to your home doesn't have alpha-lipoic acid + vit b12 + omega 3 fatty acid + chromium + selenium in stock, you can ask for one of the branded alternatives for alpha-lipoic acid + vit b12 + omega 3 fatty acid + chromium + selenium.