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- Pharmacology For Mometasone + Terbinafine
Mometasone + Terbinafine Pharmacology
Mometasone + Terbinafine
About Mometasone + TerbinafineN/AMechanism of Action of Mometasone + TerbinafineN/APharmacokinets of Mometasone + TerbinafineN/AOnset of Action for Mometasone + TerbinafineN/ADuration of Action for Mometasone + TerbinafineN/AHalf Life of Mometasone + TerbinafineN/ASide Effects of Mometasone + TerbinafineN/AContra-indications of Mometasone + TerbinafineN/ASpecial Precautions while taking Mometasone + TerbinafineN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Mometasone + TerbinafineInflammatory skin conditions wherefungal infection is also present.
Interactions for Mometasone + TerbinafineN/ATypical Dosage for Mometasone + TerbinafineN/ASchedule of Mometasone + TerbinafineN/AStorage Requirements for Mometasone + TerbinafineN/AEffects of Missed Dosage of Mometasone + TerbinafineN/AEffects of Overdose of Mometasone + TerbinafineN/AMometasone
About MometasoneA glucocorticoid steroid, Anti psoriatic,anti asthma ,anti inflammatory.Mechanism of Action of MometasoneMometasone is a topical medium potency glucocorticoid. The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits Phospholipase A2 and thus decreases the production of Prostaglandins, leukotrienes (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-a, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of MometasoneAbsorption: Mometasone is absorbed through intact skin after topical administration and the amount absorbed is depending on the type of inflammation, vehicle used, area of skin and the epidermal barrier. Absorption is increased in inflammation, occlusion and skin damage.Onset of Action for MometasoneN/ADuration of Action for MometasoneN/AHalf Life of MometasoneN/ASide Effects of Mometasone1.Thinning of epidermis
2.Burning
3.Itching
4.Irritation
5.Atrophy (Dermal changes)
6.Telangiectasia
7.Striae
8.Hypopigmentation
9.Contact dermatitis
10.Perioral dermatitis
11.Cataract, Glaucoma, Corneal ulcers caused by application around eyelids and surrounding skin
12.Dry skin
13.Stinging
14.TinglingContra-indications of Mometasone1.Hypersensitivity to Mometasone and other corticosteroids
2.Acne vulgaris
3.Acne Rosacea
5.Tuberculosis infection of the skin
6.Viral, fungal or bacterial primary infections
7.UlcersSpecial Precautions while taking Mometasone1.Avoid the use of medicament if irritation or hypersensitivity occurs
2.Prolonged use
3.Psoriasis
4.Avoid contact with eyes
5.Avoid occlusive dressing
6.Not used more than 5 days on the face or in the children
7.Withdraw gradually after prolonged use
8.Use caution on areas where the skin creases, such as armpits, knees, and elbows
9.Avoid application on large surface areaPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicated
Indications for Mometasone1.Otitis externa
2 Eczema
3.Dermatoses (secondary infected)
4.Psoriasis
5.Neuro dermatitis
6.Intertrigo
7.Lichen planus
8.Anal and vulval pruritisInteractions for MometasoneN/ATypical Dosage for MometasoneTopical: Mometasone Furoate 0.1 % cream, ointment or lotion is used.
Clean the affected area and wash with warm water and then dry. Apply 2 - 3 times daily for 2 weeks with gentle massage.
Schedule of MometasoneHStorage Requirements for MometasoneStore at room temperature. Protect from heat and light. Keep the container tightly closed. Keep out of the reach of childrenEffects of Missed Dosage of MometasoneApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of MometasoneGive supportive measures and symptomatic treatment.
Terbinafine
About TerbinafineA synthetic allylamine derivative, Antifungal.Mechanism of Action of TerbinafineTerbinafine is a fungicidal drug. It interfere the conversion of Squalene to Ergosterol by inhibiting the enzyme Squalene epoxidase.This results in accumulation of Squalene in the fungal cells and leads to membrane distortion and death of the Fungus.Pharmacokinets of TerbinafineAbsorption: It is well absorbed after oral administration.
Distribution: It is distributed in the body in protein bound form. It is concentrated in nail, skin and sebum.
Metabolism: It is metabolised to inactive metabolite in the liver.
Excretion: It is excreted mainly through urine
Onset of Action for Terbinafine2 weeksDuration of Action for TerbinafineN/AHalf Life of Terbinafine17 hourSide Effects of Terbinafine1. Nausea
2. Vomiting
3. Diarrhoea
4. Gastric upset
5. Taste disturbances
6. Visual disturbances
7. Headache
8. Neutropenia
9. Erythema
10. Itching
11. Urticaria
12. Rash
Contra-indications of Terbinafine1. Hypersensitivity to TerbinafineSpecial Precautions while taking Terbinafine1. Renal Impairment
2. Hepatic dysfunction
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationBelow 12 : ContraindicatedIndications for Terbinafine1. Tinea pedis
2. Tinea corporis
3. Tinea capitis
4. Tinea cruris
5. Onychomycosis
Interactions for TerbinafineCimetidine: Terbinafine clearance is decreased 33%.
Rifampicin: Terbinafine clearance is increased 100%.
Terfenadine: Terbinafine clearance is decreased 16%.
Cyclosprorin: Clearance of cyclospronine increased by 15%.Typical Dosage for TerbinafineAdult & Children above age 12: 250 mg daily
Finger nails: 250 mg /day for 11/2 month
Toe nails: 250 mg /day for 3 month
Schedule of TerbinafineHStorage Requirements for TerbinafineThe drug should be kept at 30 degree C.Keep away from moisture and light.Effects of Missed Dosage of TerbinafineTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose and continue the regular schedule.Effects of Overdose of TerbinafineGive supportive measures and treatment.Home Delivery for Mometasone + Terbinafine in Your City
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Mometasone + Terbinafine is a generic medicine name and there are several brands available for it. Some of the brands for mometasone + terbinafine might be better known than mometasone + terbinafine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mometasone + terbinafine in stock, you can ask for one of the branded alternatives for mometasone + terbinafine.