Diclofenac Potassium + Thiocolchicoside Pharmacology

Diclofenac Potassium + Thiocolchicoside

About Diclofenac Potassium + Thiocolchicoside
N/A
Mechanism of Action of Diclofenac Potassium + Thiocolchicoside
N/A
Pharmacokinets of Diclofenac Potassium + Thiocolchicoside
N/A
Onset of Action for Diclofenac Potassium + Thiocolchicoside
N/A
Duration of Action for Diclofenac Potassium + Thiocolchicoside
N/A
Half Life of Diclofenac Potassium + Thiocolchicoside
N/A
Side Effects of Diclofenac Potassium + Thiocolchicoside
N/A
Contra-indications of Diclofenac Potassium + Thiocolchicoside
N/A
Special Precautions while taking Diclofenac Potassium + Thiocolchicoside
N/A
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Not recommended
Indications for Diclofenac Potassium + Thiocolchicoside
1.Painful spasm of Musculoskelatal & Neuromuscular
2.Acute Low back pain
3.Post-operative, Sciatica and Neck & Shoulder Pain
Interactions for Diclofenac Potassium + Thiocolchicoside
N/A
Typical Dosage for Diclofenac Potassium + Thiocolchicoside
N/A
Schedule of Diclofenac Potassium + Thiocolchicoside
N/A
Storage Requirements for Diclofenac Potassium + Thiocolchicoside
N/A
Effects of Missed Dosage of Diclofenac Potassium + Thiocolchicoside
N/A
Effects of Overdose of Diclofenac Potassium + Thiocolchicoside
N/A

Diclofenac Potassium

About Diclofenac Potassium
NSAID, anti-inflammatory ,antipyretic and analgesic.
Mechanism of Action of Diclofenac Potassium
Diclofenac possess analgesic, anti-inflammatory and antipyretic action. It inhibits the enzyme cyclo-oxygenase and there by inhibits the synthesis of Prostaglandins (((PGs))). It is more potent against cyclo-oxygenase-2 enzyme as compared to other NSAIDs like Indomethacin, Naproxen etc. It reduces intracellular concentrations of free arachidonic acid in leukocyte by altering its release or uptake.
Pharmacokinets of Diclofenac Potassium
Absorption: Diclofenac potassium is rapidly absorbed after oral administration. It undergoes first pass metabolism. Distribution: It is distributed in highly protein bound form. Metabolism: Diclofenac potassium is metabolised in the liver to mainly 4 hydroxy Diclofenac. Excretion: Drug and metabolites are primarily excreted in urine and some amount in the bile.
Onset of Action for Diclofenac Potassium
Analgesic action: with in 60 minutes and Antirheumatic action with in 2 weeks
Duration of Action for Diclofenac Potassium
12hours
Half Life of Diclofenac Potassium
1-2 hours
Side Effects of Diclofenac Potassium
1.Nausea
2.Vomiting
3.Anorexia
4.Diarrhoea
5.Gastrointestinal bleeding
6.Abdominal distress
7.Constipation
8.Flatulence
9.Ulceration of the stomach or intestine
10.Dyspepsia
11.Headache
12.Dizziness
13.Rash
Contra-indications of Diclofenac Potassium
1.Hypersensitivity to Diclofenac and other Non steroidal anti inflammatory drugs(((NSAID)))
2.Peptic ulcer
3.Asthma
Special Precautions while taking Diclofenac Potassium
1.Hepatic impairment
2.Renal impairment
3.Hypertension
4.Blood clotting disorders
5.Gastrointestinal diseases
6.Proctitis
7.Asthma
8.Cautioned against driving, operating or activities requiring concentration
9.Avoid alcohol
10.Heart failure
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
CHILDREN below 14: contraindicated
Indications for Diclofenac Potassium
1.Rheumatoid arthritis
2.Ankylosing spondylitis
3.Acute gout
4.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints
5.Osteoarthritis
6.For the relief of pain and inflammation in dental minor surgery and orthopedic
7.Dysmenorrhoea
8.Migraine
Interactions for Diclofenac Potassium
N/A
Typical Dosage for Diclofenac Potassium
Adult: 100 - 150 mg / day in 2 - 3 divided doses.
For the relief of pain, Migraine, Dysmenorrhoea: 150 mg / day in 3 divided doses.
Osteoarthritis: 50 mg 2 - 3 times daily
Rheumatoid arthritis: 150 - 200 mg / day in 3 - 4 divided doses.
Schedule of Diclofenac Potassium
H
Storage Requirements for Diclofenac Potassium
Store Diclofenac potassium at room temperature in a tightly closed light resistant container.
Effects of Missed Dosage of Diclofenac Potassium
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Diclofenac Potassium
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.

Thiocolchicoside

About Thiocolchicoside
A GABA-A antagonist,semi-synthetic colchicoside(natural compound) derivative, A centrally acting muscle relaxant.
Mechanism of Action of Thiocolchicoside
Thiocolchicide is a GABA-A receptor antagonist, which binds to GABA-A and strychnine sensitive glycine receptors. This results the reduction of spasticity. It also has myorelaxant effects at the supraspinal level, via complex regulatory mechanisms.
Pharmacokinets of Thiocolchicoside
N/A
Onset of Action for Thiocolchicoside
N/A
Duration of Action for Thiocolchicoside
N/A
Half Life of Thiocolchicoside
N/A
Side Effects of Thiocolchicoside
1. Diarrhoea
2. Gastralgia
3. Nausea
4. Vomiting
5. Drowsiness
6. Anaphylactic reaction
Contra-indications of Thiocolchicoside
1. Contraindicated in patients with hypersensitivity to the drug
Special Precautions while taking Thiocolchicoside
1. Use with caution in patients with diarrhea
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Thiocolchicoside
Painful muscle spasm associated with
1. Degenerative vertebral disorders
2. Torticollis
3. Dorsal pain
4. Low back pain
5. Traumatological disorders
6. Neurological disorders
Interactions for Thiocolchicoside
No known interactions with other drugs.
Typical Dosage for Thiocolchicoside
Adult-
Oral- 4mg twice a day for 5 to 7 days.
Intramuscular-
4mg twice a day for 3 to 5 days.
Schedule of Thiocolchicoside
N/A
Storage Requirements for Thiocolchicoside
N/A
Effects of Missed Dosage of Thiocolchicoside
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Thiocolchicoside
Give symptomatic and supportive treatment.

Home Delivery for Diclofenac Potassium + Thiocolchicoside in Your City

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Diclofenac Potassium + Thiocolchicoside is a generic medicine name and there are several brands available for it. Some of the brands for diclofenac potassium + thiocolchicoside might be better known than diclofenac potassium + thiocolchicoside itself. If the pharmacy that's willing to deliver medicines to your home doesn't have diclofenac potassium + thiocolchicoside in stock, you can ask for one of the branded alternatives for diclofenac potassium + thiocolchicoside.