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- Pharmacology For Hydroquinone + Tretinoin
Hydroquinone + Tretinoin Pharmacology
Hydroquinone + Tretinoin
About Hydroquinone + TretinoinN/AMechanism of Action of Hydroquinone + TretinoinN/APharmacokinets of Hydroquinone + TretinoinN/AOnset of Action for Hydroquinone + TretinoinN/ADuration of Action for Hydroquinone + TretinoinN/AHalf Life of Hydroquinone + TretinoinN/ASide Effects of Hydroquinone + Tretinoin1.Aching
2.Blisters in hair follicles
3.Thinning of the skin
4.Burning or itching of the skin
5.Increased redness of the skin
6.Irritation of the skin
Contra-indications of Hydroquinone + TretinoinN/ASpecial Precautions while taking Hydroquinone + TretinoinN/APregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationNot recommendedIndications for Hydroquinone + TretinoinFor treatment of hyperpigmentation,melasma,chloasma,acne vulgaris.Interactions for Hydroquinone + TretinoinN/ATypical Dosage for Hydroquinone + TretinoinN/ASchedule of Hydroquinone + TretinoinN/AStorage Requirements for Hydroquinone + TretinoinN/AEffects of Missed Dosage of Hydroquinone + TretinoinN/AEffects of Overdose of Hydroquinone + TretinoinN/AHydroquinone
About HydroquinoneBenzenediol derivative, Depigmenting Agent.Mechanism of Action of HydroquinoneHydroquinone decreases the formation of melanin in the skin. It inhibits tyrosinase and other melanin forming enzymes and thus decreases the formation and increases the degradation of melanosomes.Pharmacokinets of HydroquinoneAbsorption: Administered topically.Onset of Action for HydroquinoneN/ADuration of Action for HydroquinoneN/AHalf Life of HydroquinoneN/ASide Effects of Hydroquinone1. Skin irritation
2. Allergic reactions
3. Rashes
4. Burning
5. Stinging
6. Itching
7. Redness
8. Irritation
Contra-indications of Hydroquinone1. Hypersensitivity to the drugSpecial Precautions while taking Hydroquinone1. Discontinue the drug if skin irritation occurs
2. Care should be taken to avoid it`s entry to eyes, nose, lips or mouth
3. Avoid exposure to sunlight
4. Use a sunscreen and wear protective clothing when exposure to the sun
5. Do not use hydroquinone topical on burned, dry, chapped, or irritated skin, or on an open wound. It could make these conditions worse
6. Hepatic impairment
7. Renal impairment
8. Along with other topical medication on the same area
Pregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationContraindicatedIndications for Hydroquinone1. Melasma
2. Freckles
3. Hyperpigmention
4. Lentigo
Interactions for HydroquinoneN/ATypical Dosage for Hydroquinone2 to 6% cream or lotion for months as required. Apply evenly on the affected areas two times daily; in the morning and evening. Massage the cream on the skin. Schedule of HydroquinoneN/AStorage Requirements for HydroquinoneStore at room temperature at a range of 15 to 30 degree C. Protect from moisture and heat. Do not freeze and keep out of reach of children.Effects of Missed Dosage of HydroquinoneUse the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of HydroquinoneRinse with water and Provide symptomatic treatment and supportive measures. Tretinoin
About TretinoinRetinoid, vitamin A metabolite, Anti-acne,in hyperpigmentation.Mechanism of Action of TretinoinTretinoin is All Trans retinoic acid (acid form of vitamin A). Tretinoin is a potent comedolytic. It stimulates mitosis and epidermal cell turnover and also promotes lysis of keratocytes. It inhibits the binding of horny cells to each other and prevents the formation of comedones. It acts as a follicular epithelium irritant. Through these actions, the comedo contents are extruded and the formation of the microcomedo, the precursor lesion of acne vulgaris, is reducedPharmacokinets of TretinoinAbsorption: Absorption after topical application is minimal.Onset of Action for TretinoinN/ADuration of Action for TretinoinN/AHalf Life of TretinoinN/ASide Effects of Tretinoin1. Feeling of warmth
2. Stinging
3. Erythema
4. Peeling
5. Blisters
6. Crusting
7. Pigmentation (hypo/hyper)
8. Contact dermatitis
9. Itching
10. Rredness
11. Edema
Contra-indications of Tretinoin1. Hypersensitivity to Tretinoin and other Retinoid
2. Abraded skin
3. Sunburn
Special Precautions while taking Tretinoin1. Eczema
2. Avoid contact with eyes, nose, mucous membrane, open wounds
3. Avoid use of medicated cosmetics and topical preparations containing high level of alcohols, spices or lime
4. Minimize exposure to sunlight and ultraviolet light
5. Avoid concomitant use of keratolytic agents
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Use with caution
Indications for Tretinoin1. Acne
2. Wrinkles
3. Photo ageing of skin
4. Dry scaly surface
Interactions for TretinoinSulfer, Resorcinol, Benzoyl peroxide or Salicylic acid : Concomitant use of topical keratolytic medications may result in significant skin irritation. Use medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect and products with high concentration of alcohol, astringents, spices or lime cautiously because of possible interaction with tretinion.Typical Dosage for TretinoinTopical:
Acne: 0.01-0.1% cream/gel/solution on the affected area 1-2 times daily.
Wrinkling: 0.05% cream is applied once daily at night.
Schedule of TretinoinHStorage Requirements for TretinoinStore at 15 - 25 degree C in a tightly closed container.Effects of Missed Dosage of TretinoinApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of TretinoinGive supportive measures and symptomatic treatment.Home Delivery for Hydroquinone + Tretinoin in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including hydroquinone + tretinoin.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for hydroquinone + tretinoin and other medicines and health products. Home delivery services for hydroquinone + tretinoin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take hydroquinone + tretinoin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for hydroquinone + tretinoin before they complete the sale. You can get this information while placing the order for hydroquinone + tretinoin with the pharmacy.
Hydroquinone + Tretinoin is a generic medicine name and there are several brands available for it. Some of the brands for hydroquinone + tretinoin might be better known than hydroquinone + tretinoin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have hydroquinone + tretinoin in stock, you can ask for one of the branded alternatives for hydroquinone + tretinoin.