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- Pharmacology For S-Amlodipine + Metoprolol
S-Amlodipine + Metoprolol Pharmacology
S-Amlodipine + Metoprolol
About S-Amlodipine + MetoprololN/AMechanism of Action of S-Amlodipine + MetoprololN/APharmacokinets of S-Amlodipine + MetoprololN/AOnset of Action for S-Amlodipine + MetoprololN/ADuration of Action for S-Amlodipine + MetoprololN/AHalf Life of S-Amlodipine + MetoprololN/ASide Effects of S-Amlodipine + MetoprololN/AContra-indications of S-Amlodipine + MetoprololN/ASpecial Precautions while taking S-Amlodipine + MetoprololN/APregnancy Related InformationContraindicated; since Amlodipine and Metoprolol are contraindicated in pregnancy.So the combination generic cannot be used in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationContraindicated; since Amlodipine is contraindicated in lactation.Children Related InformationN/AIndications for S-Amlodipine + MetoprololIt is a combination of calcium channel blocker Amlodipine and Beta blocker Metoprolol.
1.Hypertension
2.Arrhythmias
3.Angina
Interactions for S-Amlodipine + MetoprololN/ATypical Dosage for S-Amlodipine + MetoprololN/ASchedule of S-Amlodipine + MetoprololN/AStorage Requirements for S-Amlodipine + MetoprololN/AEffects of Missed Dosage of S-Amlodipine + MetoprololN/AEffects of Overdose of S-Amlodipine + MetoprololN/AS-Amlodipine
About S-AmlodipineCalcium Channel Blocker (dihydropyridine class), Anti hypertensive,anti angina.Mechanism of Action of S-AmlodipineS-Amlodipine, which is an enantiomer of Amlodipine; is a dihydropyridine Ca2+ channel blocker. It exerts it`s antihypertensive action through blocking the influx of Ca2+ ions through voltage gated L-type Calcium channels to the peripheral vascular smooth muscle cells, Coronary smooth muscle cells and to the myocardial cells and causes dilatation of vascular endothelium, decrease peripheral resistance, & reduce myocardial oxygen demand and improves oxygen supply to myocardial cells. It directly dilates vascular smooth muscle and reduces hypertension.Pharmacokinets of S-AmlodipineN/AOnset of Action for S-AmlodipineN/ADuration of Action for S-AmlodipineN/AHalf Life of S-AmlodipineN/ASide Effects of S-Amlodipine1.Headache
2.Dizziness
3.Nausea
4.Abdominal pain
5.Fatigue
6.Flushing
7.Pruritus
8.Rash
9.Dyspnea
10.Dyspepsia
11.Muscle spasm
Contra-indications of S-Amlodipine1.Hyper sensitivity to the drug or other dihydropyridines
2.Hepatic impairment
Special Precautions while taking S-AmlodipineHepatic impairmentPregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for S-AmlodipineHypertensionInteractions for S-AmlodipineN/ATypical Dosage for S-Amlodipine2.5mg once dailySchedule of S-AmlodipineHStorage Requirements for S-AmlodipineStore at room temperature below 30 degree C. Protect from moisture and light.Effects of Missed Dosage of S-AmlodipineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of S-AmlodipineGive supportive measures and symptomatic treatment.Metoprolol
About MetoprololA selective ?1 blocker, Anti-hypertensive.Mechanism of Action of MetoprololMetoprolol is a cardio selective beta-1 adrenergic antagonist.
It have negative chronotropic and negative inotropic effects on heart. It decreases oxygen consumption; cardiac work and aortic pressure It decreases nor adrenaline and renin releases. It decreases central sympathetic out flow. In sympathetic over activity, it prolongs systole by retarding conduction. It increases oxygen supply and exercise tolerance in angina patients. The drug decreases BP in hypertensive individuals.
Antimigraine action: Metoprolol is useful in migraine due to its beta blockade action. Through beta blockade action it inhibits vasodilation and relieves migraine.
Pharmacokinets of MetoprololAbsorption: well absorbed orally, bioavailabity is increased by administering along with food. Distribution: Widely distributed. Metabolism: Metabolized in liver by hydroxylation. Excretion: Excreted through urine.Onset of Action for Metoprolol15minutesDuration of Action for MetoprololUp to 1 to12 hoursHalf Life of MetoprololN/ASide Effects of Metoprolol1.Heart failure
2.Nightmares
3.Gastrointestinal problems
4.Nausea
5.Tiredness
6.Sinus bradycardia
7.Depression
8.Rash
9.Hypotension
10.Dizziness
11.Fatigue
12.Vomiting
13.Diarrhoea
14.Headache
15.Bronchospasm
Contra-indications of Metoprolol1.Hypersensitivity to the drug
2.Second or third degree heart block
3.Congestive heart failure
4.Cardiogenic shock
5.Bradycardia
6.Bronchial asthma
7.Diabetes mellitus
Special Precautions while taking Metoprolol1.Congestive heart failure
2.Hepatic impairment
3.The drug should be gradually withdraw with caution
4.Respiratory disorders
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicated.Children Related InformationContraindicatedIndications for Metoprolol1.Hypertension
2.Arrhythmias
3.Angina
4.Migraine
5.Prophylaxis of myocardial infarction
6.Thyrotoxicosis
Interactions for MetoprololThioamines: Increased efficacy of metoprolol.
Thyroid hormones: Decreased efficacy of metoprolol.
Benzodiazepines: Increased efficacy of benzodiazepines.
Clonidine: Abrupt withdrawal of clonidine may lead to hypertensive crisis.
Ergot alkaloids: Peripheral ischaemia, possible peripheral gangrene.
Lidocaine: Increased lidocaine level may occur leading to toxicity.
Prazosin: Increased postural hypotension produced by parzosin.
Sulphonylureas: Hypoglycaemic effects may be attenuated.Typical Dosage for MetoprololOral
Adult: 50 to 450mg/day
Hypertension: Starts with 50mg to 100mg/day once daily or in divided doses and gradually increases up to 450mg/day based on patient`s response
Arrhythmias:
Oral: 100mg to 150mg/day in 2 to 3 divided doses
I.V.: Dose range: 10 to 15mg. Starts with 5mg infused within 5minutes. Then repeat the therapy with the same dose at every 5minutes interval based on patient`s response
Maximum dose: 20mg
Angina: 50mg twice daily, gradually increases based on patient`s response at one week intervals
Maximum dose: 0.4gm/day
Migraine: 0.1 to 0.2gm/day in divided doses in 12th hourly to 6th hourly.
Prophylaxis of myocardial infarction: 0.1 to 0.2gm/day in divided doses
Myocardial infarction: 15mg in 3divided doses at 2minutes interval as I.V.bolus administration. Then 200mg orally in four divided doses for 2days.
Schedule of MetoprololHStorage Requirements for MetoprololStore at controlled room temperature between 20 to 25 degree C in a well closed container
Effects of Missed Dosage of MetoprololTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of MetoprololTreatment is supportive and symptomatic. After ingestion empty the stomach by induced emesis or gastric lavage. Administer activated charcoal. Treat Bradycardia with atropine 0.5 to 1mg.If required administer isoproterinol with caution. Treat hypotension with glucagons and vasopressors like epinephrine. Treat cardiac failure with diuretics and cardiac glycosides. Treat bronchospasm with isoproterinol and aminophyllineHome Delivery for S-Amlodipine + Metoprolol in Your City
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S-Amlodipine + Metoprolol is a generic medicine name and there are several brands available for it. Some of the brands for s-amlodipine + metoprolol might be better known than s-amlodipine + metoprolol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have s-amlodipine + metoprolol in stock, you can ask for one of the branded alternatives for s-amlodipine + metoprolol.