Gamma Linolenic Acid + Mecobalalamin + Vitamin C Pharmacology

Gamma Linolenic Acid + Mecobalalamin + Vitamin C

About Gamma Linolenic Acid + Mecobalalamin + Vitamin C
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Mechanism of Action of Gamma Linolenic Acid + Mecobalalamin + Vitamin C
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Pharmacokinets of Gamma Linolenic Acid + Mecobalalamin + Vitamin C
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Onset of Action for Gamma Linolenic Acid + Mecobalalamin + Vitamin C
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Duration of Action for Gamma Linolenic Acid + Mecobalalamin + Vitamin C
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Half Life of Gamma Linolenic Acid + Mecobalalamin + Vitamin C
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Side Effects of Gamma Linolenic Acid + Mecobalalamin + Vitamin C
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Contra-indications of Gamma Linolenic Acid + Mecobalalamin + Vitamin C
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Special Precautions while taking Gamma Linolenic Acid + Mecobalalamin + Vitamin C
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Pregnancy Related Information
Use with caution
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Gamma Linolenic Acid + Mecobalalamin + Vitamin C
1.Diabetic neuropathy
2.General Cardiovascular health
3.Neurological illness

Interactions for Gamma Linolenic Acid + Mecobalalamin + Vitamin C
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Typical Dosage for Gamma Linolenic Acid + Mecobalalamin + Vitamin C
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Schedule of Gamma Linolenic Acid + Mecobalalamin + Vitamin C
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Storage Requirements for Gamma Linolenic Acid + Mecobalalamin + Vitamin C
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Effects of Missed Dosage of Gamma Linolenic Acid + Mecobalalamin + Vitamin C
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Effects of Overdose of Gamma Linolenic Acid + Mecobalalamin + Vitamin C
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Gamma linolenic acid

About Gamma linolenic acid
An essential Fatty acid(omega-6 family), A dietary supplement with antiinflammatory.
Mechanism of Action of Gamma linolenic acid
GLA is metabolized to the 20-carbon polyunsaturated fatty acid DGLA, which is cyclooxygenated to prostaglandin E1 (PGE1). PGE1 elicits biologic activities by binding to surface receptors on smooth muscle cells, increasing intracellular cAMP.
GLA, via conversion to PGE1, exhibits anti-inflammatory, antithrombotic, antiproliferative, and lipid-lowering potential. It also enhances smooth muscle relaxation and vasodilation. In addition, EFAs including GLA are important constituents of membrane phospholipids, including the mitochondrial membrane, where they enhance the integrity and the fluidity of the membrane. Studies have shown that GLA has a role in management of Dry eye, Atopic eczema and cyclical mastalgia (pre-menstrual breast pain).
Pharmacokinets of Gamma linolenic acid
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Onset of Action for Gamma linolenic acid
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Duration of Action for Gamma linolenic acid
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Half Life of Gamma linolenic acid
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Side Effects of Gamma linolenic acid
1.Upset stomach
2.Diarrhea
3.Soft stool
4.Bloating
5.Gas
Contra-indications of Gamma linolenic acid
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Special Precautions while taking Gamma linolenic acid
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Gamma linolenic acid
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Interactions for Gamma linolenic acid
1.Phenothiazines and anticonvulsants due to an increased incidence of seizures.
2.Even though no cases are known of interaction with anticoagulant medications, it may be prudent to closely monitor concomitant usage.
3.Gamma Linolenic acid is shown to reduce tremors from lithium use in manic depressives.
Typical Dosage for Gamma linolenic acid
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Schedule of Gamma linolenic acid
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Storage Requirements for Gamma linolenic acid
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Effects of Missed Dosage of Gamma linolenic acid
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Effects of Overdose of Gamma linolenic acid
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Vitamin C

About Vitamin C
Water soluble vitamin, antioxidant.
Mechanism of Action of Vitamin C
Vitamin C exerts it`s action by influencing the biologic oxidations and reductions used in cellular respirations. It directly stimulates collagen synthesis and maintains intracellular connective tissue. It involves in various metabolic reactions such as 1).Hydroxylation of praline and lysine residues of protocollagen which is essential for formation and stabilization of collagen triple helix, 2).hydroxylation of carnitine, 3).Conversion of folic acid to folinic acid, 4).biosynthesis of adrenal steroids, catecholamines, oxytocin, and ADH, 5).Metabolism of cyclic nucleotides and prostaglandins. Vitamin C is important in resistance to infections.
Pharmacokinets of Vitamin C
Absorption: Well absorbed orally.
Distribution: Widely distributed both extracellularly and intracellularly, It crosses the placenta and also distributed in to the breast milk.
Metabolism: Metabolized in the liver; partly oxidized in to active dehydroascorbic acid and inactive metabolites.
Excretion: Inactive metabolites and extra drug is excreted through urine.
Onset of Action for Vitamin C
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Duration of Action for Vitamin C
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Half Life of Vitamin C
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Side Effects of Vitamin C
1. Discomfort at injection site
2. Acid urine
3. Renal calculi
4. Oxaluria
Contra-indications of Vitamin C
No known contraindications
Special Precautions while taking Vitamin C
1. Renal impairment
2. Ingestion of large doses during pregnancy has resulted in scurvy in neonates
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
May be used
Indications for Vitamin C
1. Scurvy
2. Prophylaxis and treatment of vitamin C deficiency
3. As an antioxidant to maintain natural colour and flavour of food items
4. For acidification of urine
5. Capillary fragility
6. Dental caries

Interactions for Vitamin C
Oral contraceptives and estrogens: Vitamin C increases serum levels of oestrogen resulting in adverse reactions .
Warfarin: The anticoagulant effects of warfarin is reduced.
Lab Tests: Large doses (>500 mg) of vitamin C may cause false negative urine glucose determinations. May result in false negative amine dependent stool occult blood tests.
Typical Dosage for Vitamin C
Oral:
Adults: 50 to 1000mg/day depending up on the requirement.
Pregnancy and lactation: 100 to 150mg/day
Children: 30 to 100mg/day.
Scurvy:
Oral:
Adults: 1000mg twice daily to thrice daily.
Children: 300mg to 1000mg daily.
Sub clinical scurvy:
Oral, S.C., I.M., or I.V.: 100 to 250mg once daily or twice daily depending up on the severity of the condition. Then give a maintenance dosage of 50mg/day.
Children: 100 to 300mg depending up on the severity. Then give a maintenance dose of 35mg/day.

Schedule of Vitamin C
C1 (Oral)
C (Parenteral)
Storage Requirements for Vitamin C
Store in a cool dry area in a well closed container. Protects from moisture, light and direct heat.
Effects of Missed Dosage of Vitamin C
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Vitamin C
Discontinue the therapy and provide symptomatic and supportive measures.

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