Mecobalamin + Benfotiamine + Vitamin B6 + Folic acid Pharmacology

Mecobalamin + Benfotiamine + Vitamin B6 + Folic acid

About Mecobalamin + Benfotiamine + Vitamin B6 + Folic acid
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Mechanism of Action of Mecobalamin + Benfotiamine + Vitamin B6 + Folic acid
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Pharmacokinets of Mecobalamin + Benfotiamine + Vitamin B6 + Folic acid
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Onset of Action for Mecobalamin + Benfotiamine + Vitamin B6 + Folic acid
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Duration of Action for Mecobalamin + Benfotiamine + Vitamin B6 + Folic acid
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Half Life of Mecobalamin + Benfotiamine + Vitamin B6 + Folic acid
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Side Effects of Mecobalamin + Benfotiamine + Vitamin B6 + Folic acid
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Contra-indications of Mecobalamin + Benfotiamine + Vitamin B6 + Folic acid
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Special Precautions while taking Mecobalamin + Benfotiamine + Vitamin B6 + Folic acid
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Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Mecobalamin + Benfotiamine + Vitamin B6 + Folic acid
1.Alcoholic neuropathy
2.Diabetic neuropathy
3.Drug induced neuropathy
4.Peripheral neuropathy
Interactions for Mecobalamin + Benfotiamine + Vitamin B6 + Folic acid
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Typical Dosage for Mecobalamin + Benfotiamine + Vitamin B6 + Folic acid
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Schedule of Mecobalamin + Benfotiamine + Vitamin B6 + Folic acid
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Storage Requirements for Mecobalamin + Benfotiamine + Vitamin B6 + Folic acid
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Effects of Missed Dosage of Mecobalamin + Benfotiamine + Vitamin B6 + Folic acid
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Effects of Overdose of Mecobalamin + Benfotiamine + Vitamin B6 + Folic acid
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Mecobalamin

About Mecobalamin
Water soluble, Form of Vitamin B12
Mechanism of Action of Mecobalamin
Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.
Pharmacokinets of Mecobalamin
Absorption: Absorbed after oral, sublingual, injection
Excretion: Excretion via urine
Onset of Action for Mecobalamin
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Duration of Action for Mecobalamin
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Half Life of Mecobalamin
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Side Effects of Mecobalamin
1.Oral: Anorexia, nausea, vomiting and diarrhea
2.Parenteral: Rash, headache, hot sensation, diaphoresis and pain/induration at IM inj site
Contra-indications of Mecobalamin
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Special Precautions while taking Mecobalamin
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Pregnancy Related Information
May be used
Old Age Related Information
May be used
Breast Feeding Related Information
May be used
Children Related Information
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Indications for Mecobalamin
1.Peripheral neuropathies
2.Megaloblastic anaemia
Interactions for Mecobalamin
1.Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicines
2.Reduced serum concentrations with oral contraceptives
3.Reduced effects in anaemia with parenteral chloramphenicol
Typical Dosage for Mecobalamin
Peripheral neuropathies
Oral: Adult: 1500 mcg/day in 3 divided doses
Parenteral: 500 mcg daily IM/IV 3 times/wk

Megaloblastic anaemia caused by vitamin B12 deficiency
Parenteral: Adult: 500 mcg daily IM/IV 3 times/wk. Maintenance dose: After about 2 mth of therapy, reduce dose to single admin of 500 mcg every 1-3 mth.
Schedule of Mecobalamin
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Storage Requirements for Mecobalamin
Oral: Store at room temperature. Protect from moisture and light.
Parenteral: Store at room temperature. Do not expose to direct light.


Effects of Missed Dosage of Mecobalamin
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Effects of Overdose of Mecobalamin
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Benfotiamine

About Benfotiamine
Synthetic S-acyl derivative of thiamine (vitamine B1), Antioxidant ,anti-AGE(Advanced glycation end product) supplement, Treating Diabetic Complications.
Mechanism of Action of Benfotiamine
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Pharmacokinets of Benfotiamine
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Onset of Action for Benfotiamine
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Duration of Action for Benfotiamine
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Half Life of Benfotiamine
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Side Effects of Benfotiamine
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Contra-indications of Benfotiamine
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Special Precautions while taking Benfotiamine
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Benfotiamine
1.Management of diabetic neuropathy, diabetic nephropathy and diabetic retinopathy
2.Beri Beri
3.Wenicke-korsakoff syndrome
Interactions for Benfotiamine
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Typical Dosage for Benfotiamine
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Schedule of Benfotiamine
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Storage Requirements for Benfotiamine
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Effects of Missed Dosage of Benfotiamine
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Effects of Overdose of Benfotiamine
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About
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Side Effects of
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Contra-indications of
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Special Precautions while taking
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Pregnancy Related Information
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Old Age Related Information
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Children Related Information
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Indications for
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Interactions for
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Typical Dosage for
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Schedule of
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Storage Requirements for
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Effects of Missed Dosage of
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Effects of Overdose of
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Folic Acid

About Folic Acid
Dietary supplement, Folate derivative( B9 ), Water Soluble Vitamin.
Mechanism of Action of Folic Acid
Folic acid reduced by enzymes folate reductase and dihydrofolate reductase and forms dihydrofolic acid tetrahydrofolic acid respectively. Tetrahydrofolic acid acts as a coenzyme which mediates a number of one carbon transfer reactions by carrying a methyl group as an adduct. It involves a number of reactions such as 1).conversion of homocysteine to methionine. 2).synthesis of thymidylate which is an essential constituent of DNA from methylene-tetrahydrofolic acid. 3). Conversion of serine to glycine by tetrahydrofolic acid and forms methylene-tetrahydrofolic acid. 4).to introduce carbon units at position 2 and 8 during de novo purine synthesis requires formyl-tetrahydrofolic acid and methenyl-tetrahydrofolic acid.5).generation and utilization of "formate pool". 6).For mediating formino group transfer in histidine metabolism. Folic acid is required to maintain normal erythropoiesis and nucleoprotein synthesis.
Pharmacokinets of Folic Acid
Absorption: Well absorbed orally
Distribution: Widely distributed in the body and highest concentration is seen in liver. It appears in the CSF and breast milk
Metabolism: Metabolized in to N-methyl tetrahydrofolic acid in liver
Excretion: Extra drug is excreted unchanged in urine. A small portion of folate is lost by a combination of urinary and fecal excretion and oxidative cleavage of molecule.
Onset of Action for Folic Acid
Oral: 20 to 30minutes
I.V.: 5 minutes
I.M.:10 to 20minutes
Duration of Action for Folic Acid
Oral: 3 to 6 hours
I.V.:3 to 6minutes
I.M.:3 to 6hours
Half Life of Folic Acid
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Side Effects of Folic Acid
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Contra-indications of Folic Acid
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Special Precautions while taking Folic Acid
1. In patients with undiagnosed anaemia; because it may mask pernicious anaemia
2. In pernicious anaemia and other megaloblastic where vitamin B12 is deficient
Pregnancy Related Information
May be used
Old Age Related Information
May be used
Breast Feeding Related Information
May be used
Children Related Information
May be used
Indications for Folic Acid
1. Megaloblastic anaemia
2. Folic acid deficiency
3. Anaemias of pregnancy
4. Nutritional anaemia
5. Alcoholism
6. Tropical sprue
7. Non tropical sprue
Interactions for Folic Acid
1. Hypersensitivity reactions with injection form
2. Bronchospasm
Typical Dosage for Folic Acid
Oral: 5mg 1 to 4 times daily; depending up on the severity of deficiency.
Maintenance dosage: Half of the therapeutic dosage.
Children: 2.5 to 5mg 1 to 2 times daily.
Schedule of Folic Acid
C1 (Oral)
C (Parenteral)
Storage Requirements for Folic Acid
Store at controlled room temperature at a range of 15 to 25 degree C in a well closed container. Protect from excess heat, light and moisture.
Effects of Missed Dosage of Folic Acid
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Folic Acid
Relatively non toxic. Provide symptomatic treatment and supportive measures.

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