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- Pharmacology For Levofloxacin + Ambroxol
Levofloxacin + Ambroxol Pharmacology
Levofloxacin + Ambroxol
About Levofloxacin + AmbroxolN/AMechanism of Action of Levofloxacin + AmbroxolN/APharmacokinets of Levofloxacin + AmbroxolN/AOnset of Action for Levofloxacin + AmbroxolN/ADuration of Action for Levofloxacin + AmbroxolN/AHalf Life of Levofloxacin + AmbroxolN/ASide Effects of Levofloxacin + AmbroxolN/AContra-indications of Levofloxacin + AmbroxolN/ASpecial Precautions while taking Levofloxacin + AmbroxolN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Levofloxacin + AmbroxolTo treat severe or life-threatening bacterial infections or bacterial infections which have failed to respond to other antibiotic classes of Respiratory tract.
Interactions for Levofloxacin + AmbroxolN/ATypical Dosage for Levofloxacin + AmbroxolN/ASchedule of Levofloxacin + AmbroxolN/AStorage Requirements for Levofloxacin + AmbroxolN/AEffects of Missed Dosage of Levofloxacin + AmbroxolN/AEffects of Overdose of Levofloxacin + AmbroxolN/ALevofloxacin
About LevofloxacinThird generation fluoroquinolone (or quinolone), A broad spectrum antiinfective.Mechanism of Action of LevofloxacinLevofloxacin is a broad spectrum antibacterial agent. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Levofloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis. Pharmacokinets of LevofloxacinAbsorption: It is rapidly and completely absorbed after oral administration. Distribution: It is distributed widely in the body. Metabolism: It undergoes insignificant metabolism in the liver. Excretion: Drug is excreted mainly through urine.Onset of Action for LevofloxacinN/ADuration of Action for LevofloxacinN/AHalf Life of Levofloxacin6 - 8 hourSide Effects of Levofloxacin1. Nausea
2. Vomiting
3. Diarrhoea
4. Abdominal discomfort
5. Restlessness
6. Dizziness
7. Drowsiness
8. Arthralgia
9. Rash
10. Confusion
11. Insomnia
12. Anorexia
13. Bad taste
14. Headache
15. Photosensitivity.Contra-indications of LevofloxacinHypersensitivity to Levofloxacin and other FluoroquinolonesSpecial Precautions while taking Levofloxacin1.Hepatic impairment
2.Renal impairment
3.Epilepsy
4.Cerebral arteriosclerosis
Caution while driving the vehicle or operating machine or involved in any hazardous activities. Avoid exposure to sun light
Pregnancy Related InformationContraindicated.Old Age Related InformationUse with cautionBreast Feeding Related InformationContraindicated.Children Related InformationContraindicated
Indications for Levofloxacin1.Sinusitis
2.Bronchitis
3.Pneumonia
4.Urinary tract infection
5.Traveler`s diarrhoea
6.Skin and soft tissue infections
7.UrethritisInteractions for LevofloxacinN/ATypical Dosage for LevofloxacinAdults:
Dose is determined on the basis of severity of the infection, type of infecting organism, age, weight and renal function of the patient.
Sinusitis, Bronchitis, Pneumonia, Skin and soft tissue infections: 500 mg daily for 1 - 2 week
Urinary tract infection: 250 mg / day for 10 days
Traveler`s diarrhoea: 500 mg / day along with Loperamide
Urethritis: 500 mg orally once daily for 7 days
Schedule of LevofloxacinHStorage Requirements for LevofloxacinStore at 25 - 30 degree C in a tightly closed container.Effects of Missed Dosage of LevofloxacinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Effects of Overdose of LevofloxacinGive supportive measures and symptomatic treatment. Empty the stomach. Maintain appropriate hydration.Ambroxol
About AmbroxolActive N-desmethyl metabolite of bromhexine,systemically active mucolytic agent, Secretomotoric and expectoration improver.Mechanism of Action of AmbroxolAmbroxol hydrochloride acts as an expectoration improver and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and by breaking network of fibres in tenacious sputum . It induces thin copious bronchial secretion and possesses antioxidant properties.Pharmacokinets of AmbroxolN/AOnset of Action for AmbroxolN/ADuration of Action for AmbroxolN/AHalf Life of AmbroxolN/ASide Effects of Ambroxol1. Rhinorrhoea
2. Lacrimations
3. Allergic reactions
4. Gastric irritation.Contra-indications of AmbroxolHypersensitivity to the Ambroxol hydrochloride or Bromhexine.Special Precautions while taking Ambroxol1.Hepatic impairment
2.Renal impairment
3.Gastric and duodenal ulcer
4.Convulsive disorders
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Ambroxol1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
3. Bronchitis
4. Pharyngitis
5. Laryngitis
6. Rhinitis
7. Sinusitis
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10. Chronic Pneumonia.Interactions for AmbroxolN/ATypical Dosage for AmbroxolOral: 15mg to 30mg three times daily.
Children (6 to 12years): 5ml 2 to 3 times daily
Children (2 to 6years): 2.5ml thrice daily. (5ml liquid contains 30mg Ambroxol hydrochloride)
Children up to 2 years: 7.5mg two times daily
Schedule of AmbroxolHStorage Requirements for AmbroxolStore in a cool dry place and protect from light. Keep out of reach of children.Effects of Missed Dosage of AmbroxolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AmbroxolProvide symptomatic treatment and supportive measures.Home Delivery for Levofloxacin + Ambroxol in Your City
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Levofloxacin + Ambroxol is a generic medicine name and there are several brands available for it. Some of the brands for levofloxacin + ambroxol might be better known than levofloxacin + ambroxol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have levofloxacin + ambroxol in stock, you can ask for one of the branded alternatives for levofloxacin + ambroxol.