Folic Acid + Docosahexenoic Acid + Lycopene + Zinc Pharmacology

Folic Acid + Docosahexenoic Acid + Lycopene + Zinc

About Folic Acid + Docosahexenoic Acid + Lycopene + Zinc
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Mechanism of Action of Folic Acid + Docosahexenoic Acid + Lycopene + Zinc
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Pharmacokinets of Folic Acid + Docosahexenoic Acid + Lycopene + Zinc
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Onset of Action for Folic Acid + Docosahexenoic Acid + Lycopene + Zinc
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Duration of Action for Folic Acid + Docosahexenoic Acid + Lycopene + Zinc
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Half Life of Folic Acid + Docosahexenoic Acid + Lycopene + Zinc
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Side Effects of Folic Acid + Docosahexenoic Acid + Lycopene + Zinc
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Contra-indications of Folic Acid + Docosahexenoic Acid + Lycopene + Zinc
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Special Precautions while taking Folic Acid + Docosahexenoic Acid + Lycopene + Zinc
N/A
Pregnancy Related Information
Use with caution
Old Age Related Information
May be used
Breast Feeding Related Information
May be used
Children Related Information
May be used
Indications for Folic Acid + Docosahexenoic Acid + Lycopene + Zinc
1.Folate-deficient megaloblastic anaemia
2.Prophylaxis of megaloblastic anaemia in pregnancy
3.Prophylaxis of neural tube defect in pregnancy
4.As supplement for women of child-bearing potential

Interactions for Folic Acid + Docosahexenoic Acid + Lycopene + Zinc
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Typical Dosage for Folic Acid + Docosahexenoic Acid + Lycopene + Zinc
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Schedule of Folic Acid + Docosahexenoic Acid + Lycopene + Zinc
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Storage Requirements for Folic Acid + Docosahexenoic Acid + Lycopene + Zinc
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Effects of Missed Dosage of Folic Acid + Docosahexenoic Acid + Lycopene + Zinc
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Effects of Overdose of Folic Acid + Docosahexenoic Acid + Lycopene + Zinc
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Folic Acid

About Folic Acid
Dietary supplement, Folate derivative( B9 ), Water Soluble Vitamin.
Mechanism of Action of Folic Acid
Folic acid reduced by enzymes folate reductase and dihydrofolate reductase and forms dihydrofolic acid tetrahydrofolic acid respectively. Tetrahydrofolic acid acts as a coenzyme which mediates a number of one carbon transfer reactions by carrying a methyl group as an adduct. It involves a number of reactions such as 1).conversion of homocysteine to methionine. 2).synthesis of thymidylate which is an essential constituent of DNA from methylene-tetrahydrofolic acid. 3). Conversion of serine to glycine by tetrahydrofolic acid and forms methylene-tetrahydrofolic acid. 4).to introduce carbon units at position 2 and 8 during de novo purine synthesis requires formyl-tetrahydrofolic acid and methenyl-tetrahydrofolic acid.5).generation and utilization of "formate pool". 6).For mediating formino group transfer in histidine metabolism. Folic acid is required to maintain normal erythropoiesis and nucleoprotein synthesis.
Pharmacokinets of Folic Acid
Absorption: Well absorbed orally
Distribution: Widely distributed in the body and highest concentration is seen in liver. It appears in the CSF and breast milk
Metabolism: Metabolized in to N-methyl tetrahydrofolic acid in liver
Excretion: Extra drug is excreted unchanged in urine. A small portion of folate is lost by a combination of urinary and fecal excretion and oxidative cleavage of molecule.
Onset of Action for Folic Acid
Oral: 20 to 30minutes
I.V.: 5 minutes
I.M.:10 to 20minutes
Duration of Action for Folic Acid
Oral: 3 to 6 hours
I.V.:3 to 6minutes
I.M.:3 to 6hours
Half Life of Folic Acid
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Side Effects of Folic Acid
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Contra-indications of Folic Acid
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Special Precautions while taking Folic Acid
1. In patients with undiagnosed anaemia; because it may mask pernicious anaemia
2. In pernicious anaemia and other megaloblastic where vitamin B12 is deficient
Pregnancy Related Information
May be used
Old Age Related Information
May be used
Breast Feeding Related Information
May be used
Children Related Information
May be used
Indications for Folic Acid
1. Megaloblastic anaemia
2. Folic acid deficiency
3. Anaemias of pregnancy
4. Nutritional anaemia
5. Alcoholism
6. Tropical sprue
7. Non tropical sprue
Interactions for Folic Acid
1. Hypersensitivity reactions with injection form
2. Bronchospasm
Typical Dosage for Folic Acid
Oral: 5mg 1 to 4 times daily; depending up on the severity of deficiency.
Maintenance dosage: Half of the therapeutic dosage.
Children: 2.5 to 5mg 1 to 2 times daily.
Schedule of Folic Acid
C1 (Oral)
C (Parenteral)
Storage Requirements for Folic Acid
Store at controlled room temperature at a range of 15 to 25 degree C in a well closed container. Protect from excess heat, light and moisture.
Effects of Missed Dosage of Folic Acid
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Folic Acid
Relatively non toxic. Provide symptomatic treatment and supportive measures.

Docosahexenoic Acid

About Docosahexenoic Acid
An omega-3 fatty acid(polyunsaturated fatty acids, PUFAs), An essential fatty acid, brain food ,Antiatherosclerotic.
Mechanism of Action of Docosahexenoic Acid
It is found with Eicosapentaenoic acid. Omega-3 fatty acids are of polyunsaturated fatty acids that derives from food. They help to lower triglycerides and cholesterol and increase HDL cholesterol (the Good cholesterol) and thus improves lipid profile. Omega 3 fatty acids may also act as an anticoagulant to prevent blood clotting. They have anti-inflammatory actions and also lower high blood pressure. The incorporation of Omega-3 fatty acids in the membranes of the cells increases the physicochemical stability and functional integrity. It also makes the cells less susceptible to oxidative damage and also decreases the formation of lipid peroxidases. They protect from cardiovascular disorders and may also reduce the risks and symptoms for other disorders including diabetes, dementia, rheumatoid arthritis, asthma, stroke, inflammatory bowel disease, ulcerative colitis, mental decline, and some cancers. They aid in proper functioning of central nervous system.
Hypolipidaemic action: It produces a reduction in plasma triglycerides by reducing bad cholesterol or very low density lipoproteins.
Antiinflammatory action: Omega - 3 fatty acids are long chain poly unsaturated fatty acids.They compete with arachidonic acid for cyclo-oxygenase and lipoxygenase They inhibits inflammatory mediators by inhibiting leukotriene synthesis pathway.
Antithrombotic effect: They promote vasodilatation, a reduction in platelet aggregation, increased bleeding time and decreased platelet counts
Pharmacokinets of Docosahexenoic Acid
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Onset of Action for Docosahexenoic Acid
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Duration of Action for Docosahexenoic Acid
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Half Life of Docosahexenoic Acid
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Side Effects of Docosahexenoic Acid
1.Loose stools
2.Abdominal discomfort
3.Belching
4.Prolong bleeding time slightly
5.Nausea
6.Vomiting
7.Diarrhoea
8.Constipation
Contra-indications of Docosahexenoic Acid
Hypersensitivity to the drug
Special Precautions while taking Docosahexenoic Acid
1.Haemorrhagic disorders
2.Patient on anticoagulants therapy
3.Hepatic impairment
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Infants: Contraindicated
Indications for Docosahexenoic Acid
1.Coronary artery disease
2.Hypertension
3.Atherosclerosis related disorders
4.Obesity
5.Fatty diet
6.Hyperlipidaemia
7.Smoking
8.Diabetes
Interactions for Docosahexenoic Acid
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Typical Dosage for Docosahexenoic Acid
120 - 240 mg / day in single or 2 divided dose with Eicosapentaenoic acid.
Schedule of Docosahexenoic Acid
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Storage Requirements for Docosahexenoic Acid
Store in airtight containers. Protect from light.
Effects of Missed Dosage of Docosahexenoic Acid
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Docosahexenoic Acid
Give supportive measures and symptomatic treatment.

Lycopene

About Lycopene
Carotenoid;Terpenes and terpenoids, Dietary antioxidant.
Mechanism of Action of Lycopene
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Pharmacokinets of Lycopene
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Onset of Action for Lycopene
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Duration of Action for Lycopene
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Half Life of Lycopene
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Side Effects of Lycopene
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Contra-indications of Lycopene
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Special Precautions while taking Lycopene
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Lycopene
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Interactions for Lycopene
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Typical Dosage for Lycopene
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Schedule of Lycopene
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Storage Requirements for Lycopene
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Effects of Missed Dosage of Lycopene
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Effects of Overdose of Lycopene
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Zinc

About Zinc
Trance metal, Dietary mineral, Nutritional supplement,Treatment of zinc deficiency,in wound healing.
Mechanism of Action of Zinc
Zinc acts as a cofactor for more than 70 different enzymes. Zinc dependent enzymes are involved in the metabolism of carbohydrates, lipids, and proteins. Zinc facilitates wound healing, normal growth rates, normal skin hydration and maintains senses of taste and smell. It provides normal growth and tissue repair. It also helps in development of cell mediated immunity.
Pharmacokinets of Zinc
Absorption: Poorly absorbed orally, Distribution: Zinc is distributed mainly in to skeletal muscle, skin, bone, pancreas, kidney, liver, retina, prostate, RBC, and WBC. Excretion: Excreted mainly through intestine; only 2% loss in the urine.
Onset of Action for Zinc
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Duration of Action for Zinc
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Half Life of Zinc
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Side Effects of Zinc
1. Nausea
2. Vomiting
3. Abdominal distress
4. Gastric ulceration
5. Rashes
Contra-indications of Zinc
N/A
Special Precautions while taking Zinc
1.Don`t exceed prescribed dose
2.Renal failure
3.Biliary obstruction

Pregnancy Related Information
Use with caution
Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
N/A
Indications for Zinc
1. Zinc deficiency
2. Acne vulgaris
3. Chronic skin ulcers
4. Adjunct to antimicrobials
5. Delayed wound healing
6. Alopecia
Interactions for Zinc
Fluoroquinolones, Tetracyclines: Decreased GI absorption and serum levels of some fluoroquinolone.
Pencillamine: Reduced absorption of zinc.
Iron: Reduced absorption of iron and vice versa.

Typical Dosage for Zinc
Adults: 25 to 50mg zinc daily or 1 to 2 tablets daily.
Children: 5mg/kg 1 to 3 times daily.
Schedule of Zinc
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Storage Requirements for Zinc
Store at a temperature below 30 degree C
Effects of Missed Dosage of Zinc
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Zinc
Provide symptomatic treatment and supportive measures

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