Cefepime + Tazobactam Pharmacology

Cefepime + Tazobactam

About Cefepime + Tazobactam

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Mechanism of Action of Cefepime + Tazobactam

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Pharmacokinets of Cefepime + Tazobactam

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Onset of Action for Cefepime + Tazobactam

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Duration of Action for Cefepime + Tazobactam

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Half Life of Cefepime + Tazobactam

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Side Effects of Cefepime + Tazobactam

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Contra-indications of Cefepime + Tazobactam

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Special Precautions while taking Cefepime + Tazobactam

N/A

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

Contraindicated

Indications for Cefepime + Tazobactam

1.In the treatment of moderate to severe pneumonia
2.Febrile neutropenic patients empirically
3.Uncomplicated and complicated urinary tract infections
4.Uncomplicated and complicated skin and skin structure infections
5.Complicated intra-abdominal infections.

Interactions for Cefepime + Tazobactam

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Typical Dosage for Cefepime + Tazobactam

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Schedule of Cefepime + Tazobactam

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Storage Requirements for Cefepime + Tazobactam

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Effects of Missed Dosage of Cefepime + Tazobactam

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Effects of Overdose of Cefepime + Tazobactam

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Cefepime

About Cefepime

Fourth Generation cephalosporin antibiotic.

Mechanism of Action of Cefepime

Cefepime is a 3rd generation cephalosporin which exerts its bactericidal action by inhibiting bacterial cell wall synthesis. Cefepime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefipime

Pharmacokinets of Cefepime

Well absorbed after Parenteral administration, Distribution: widely distributed, Metabolism: It is metabolized inside the body Excretion: Excreted mainly through urine

Onset of Action for Cefepime

30 minutes

Duration of Action for Cefepime

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Half Life of Cefepime

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Side Effects of Cefepime

1.Pain after I.M. injection & thrombophlebitis after I.V. injection.
2 Rashes
3.Vaginitis
4.Pruritus
5.Candiasis
6.Nephrotoxicity
7.Pseudo membranous colitis
8.Nausea
9.Vomiting
10.Elevated liver enzymes
11.Headache
12.Dizziness
13.Hypotention
14.Vertigo

Contra-indications of Cefepime

1.Hypersensitivity to cephalosporins or Penicillins
2.Along with other nephrotoxic drugs

Special Precautions while taking Cefepime

1.Renal impairment
2.Pseudo membranous colitis

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution.

Breast Feeding Related Information

Use with caution.

Children Related Information

Contraindicated
Neonates: contraindicated

Indications for Cefepime

1.Pneumonia
2.Resistant hospital acquired infections
3.Septicemia,
4.Empiric therapy in febrile neutropenic patients
5.Urinary tract infections
6.Pyelonephritis
7.Tonsillitis, Pharyngitis etc.
8.Skin & soft tissue infections

Interactions for Cefepime

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Typical Dosage for Cefepime

Adults: 1 to 2 gm I.V. twice daily or thrice daily
Urinary tract infections:500mg to 1gm I.V. or I.M. twice daily for 10 days. In severe cases dose may be increased up to 2gm twice daily for 10 days
Infections in neutropenic patients:6gm/day in 3 divided doses; for 1week
Pneumonia:1 to 2 gm twice daily for 10 days
Intra abdominal infections:2gm twice daily for 10 days

Schedule of Cefepime

Storage Requirements for Cefepime

Store in a temperature range of 2 degree to 25 degree C and protect from light.

Effects of Missed Dosage of Cefepime

Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.

Effects of Overdose of Cefepime

Symptoms of over dosage include neuromuscular disorders and may precipitate seizures. Treatment includes removal of drug from the body by hemodialysis & supportive measures

Tazobactam

About Tazobactam

A Penicillanic acid sulfone beta-lactamase inhibitor, penams, To increase the antibacterial activity of penicillins against ?-lactamase?producing organisms.

Mechanism of Action of Tazobactam

Tazobactam is a Penicillanic acid sulfone beta lactamase inhibitor.Sulbactam has no significant antimicrobial activity, despite sharing the ?-lactam ring that is characteristic of beta-lactam antibiotics. This similarity in chemical structure helps the Tazobactam to act as a competitive inhibitor of beta-lactamase enzyme secreted by certain bacteria that are resistant to beta-lactam antibiotics. This inhibition restores the antibacterial activity of beta-lactam antibiotics against ?-lactamase-secreting resistant bacteria.It is usually given in combination with Piperacillin.

Pharmacokinets of Tazobactam

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Onset of Action for Tazobactam

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Duration of Action for Tazobactam

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Half Life of Tazobactam

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Side Effects of Tazobactam

1.Gastrointestinal disturbances
2.Headache
3.Dizziness
4.Insomnia
5.Rash
6.Pain
7.Hypertension
8.Edema
9.Pruritus
10.Agitation
11.Local reactions

Contra-indications of Tazobactam

Hypersensitivity to Tazobactam

Special Precautions while taking Tazobactam

1.Renal impairment
2.Cystic fibrosis
3.Haematopoiesis
4.Monitor electrolytes
5.Discontinue if bleeding disorders occur

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

Contraindicated

Indications for Tazobactam

1.Skin infections
2.Pneumonia
3.Postpartum endometritis
4.Pelvic inflammatory disease
5.Appendicitis
6.Peritonitis

Interactions for Tazobactam

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Typical Dosage for Tazobactam

IV Infusion over 30 minutes.
Adults: 3 to 4 grams of Piperacillin, in combination with 0.375 to 0.5 grams of Tazobactam, every 6 - 8 hours for 7 - 10 days.

Schedule of Tazobactam

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Storage Requirements for Tazobactam

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Effects of Missed Dosage of Tazobactam

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Effects of Overdose of Tazobactam

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Home Delivery for Cefepime + Tazobactam in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cefepime + tazobactam and other medicines and health products. Home delivery services for cefepime + tazobactam may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take cefepime + tazobactam only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cefepime + tazobactam before they complete the sale. You can get this information while placing the order for cefepime + tazobactam with the pharmacy.

Cefepime + Tazobactam is a generic medicine name and there are several brands available for it. Some of the brands for cefepime + tazobactam might be better known than cefepime + tazobactam itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cefepime + tazobactam in stock, you can ask for one of the branded alternatives for cefepime + tazobactam.