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- Pharmacology For Mecobalamin + L-Carnitine + Folic Acid
Mecobalamin + L-Carnitine + Folic Acid Pharmacology
Mecobalamin + L-Carnitine + Folic Acid
About Mecobalamin + L-Carnitine + Folic AcidN/AMechanism of Action of Mecobalamin + L-Carnitine + Folic AcidN/APharmacokinets of Mecobalamin + L-Carnitine + Folic AcidN/AOnset of Action for Mecobalamin + L-Carnitine + Folic AcidN/ADuration of Action for Mecobalamin + L-Carnitine + Folic AcidN/AHalf Life of Mecobalamin + L-Carnitine + Folic AcidN/ASide Effects of Mecobalamin + L-Carnitine + Folic AcidN/AContra-indications of Mecobalamin + L-Carnitine + Folic AcidN/ASpecial Precautions while taking Mecobalamin + L-Carnitine + Folic AcidN/APregnancy Related InformationUse with cautionOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Mecobalamin + L-Carnitine + Folic AcidN/AInteractions for Mecobalamin + L-Carnitine + Folic AcidN/ATypical Dosage for Mecobalamin + L-Carnitine + Folic AcidN/ASchedule of Mecobalamin + L-Carnitine + Folic AcidN/AStorage Requirements for Mecobalamin + L-Carnitine + Folic AcidN/AEffects of Missed Dosage of Mecobalamin + L-Carnitine + Folic AcidN/AEffects of Overdose of Mecobalamin + L-Carnitine + Folic AcidN/AMecobalamin
About MecobalaminWater soluble, Form of Vitamin B12Mechanism of Action of MecobalaminMecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.Pharmacokinets of MecobalaminAbsorption: Absorbed after oral, sublingual, injection
Excretion: Excretion via urine
Onset of Action for MecobalaminN/ADuration of Action for MecobalaminN/AHalf Life of MecobalaminN/ASide Effects of Mecobalamin1.Oral: Anorexia, nausea, vomiting and diarrhea
2.Parenteral: Rash, headache, hot sensation, diaphoresis and pain/induration at IM inj site
Contra-indications of MecobalaminN/ASpecial Precautions while taking MecobalaminN/APregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationN/AIndications for Mecobalamin1.Peripheral neuropathies
2.Megaloblastic anaemia
Interactions for Mecobalamin1.Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicines
2.Reduced serum concentrations with oral contraceptives
3.Reduced effects in anaemia with parenteral chloramphenicol
Typical Dosage for MecobalaminPeripheral neuropathies
Oral: Adult: 1500 mcg/day in 3 divided doses
Parenteral: 500 mcg daily IM/IV 3 times/wk
Megaloblastic anaemia caused by vitamin B12 deficiency
Parenteral: Adult: 500 mcg daily IM/IV 3 times/wk. Maintenance dose: After about 2 mth of therapy, reduce dose to single admin of 500 mcg every 1-3 mth.Schedule of MecobalaminN/AStorage Requirements for MecobalaminOral: Store at room temperature. Protect from moisture and light.
Parenteral: Store at room temperature. Do not expose to direct light.
Effects of Missed Dosage of MecobalaminN/AEffects of Overdose of MecobalaminN/AL-carnitine
About L-carnitineDietary supplement, Amino acid derivative, Antioxidant.Mechanism of Action of L-carnitineCarnitine is an essential co-factor of fatty acid metabolism in the heart, liver, and skeletal muscle. It is normally synthesised in the liver, brain, and kidneys in sufficient quantities to meet human requirements. It is an antioxidant. It protects neurons from damage caused by super oxide radicals.Pharmacokinets of L-carnitineLevocarnitine is absorbed slowly and incompletely from the small intestine. Distribution: It is distributed mainly in free form. Metabolism: It undergoes minimal metabolism. Excretion: It is excreted mainly in urine and small amount through faeces.Onset of Action for L-carnitineN/ADuration of Action for L-carnitineN/AHalf Life of L-carnitineN/ASide Effects of L-carnitine1.Nausea
2.Vomiting
3.Diarrhoea
4.Abdominal cramps
Contra-indications of L-carnitineN/ASpecial Precautions while taking L-carnitine1.Severe renal impairment
2.Diabetic patients
Pregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for L-carnitine1.As antioxidant
2.Carnitine deficiency
Interactions for L-carnitineN/ATypical Dosage for L-carnitineOral
Adult: 100 - 200 mg/kg daily in 2 to 4 divided doses.
Children: 50 to 100 mg/kg daily in 2 to 4 divided doses
Parenteral (IV)
Adult: 50 to 100 mg/kg daily is given in 3 to 4 divided doses by slow intravenous injection over 2 to 3 minutes.
Schedule of L-carnitineHStorage Requirements for L-carnitineN/AEffects of Missed Dosage of L-carnitineN/AEffects of Overdose of L-carnitineN/AFolic Acid
About Folic AcidDietary supplement, Folate derivative( B9 ), Water Soluble Vitamin.Mechanism of Action of Folic AcidFolic acid reduced by enzymes folate reductase and dihydrofolate reductase and forms dihydrofolic acid tetrahydrofolic acid respectively. Tetrahydrofolic acid acts as a coenzyme which mediates a number of one carbon transfer reactions by carrying a methyl group as an adduct. It involves a number of reactions such as 1).conversion of homocysteine to methionine. 2).synthesis of thymidylate which is an essential constituent of DNA from methylene-tetrahydrofolic acid. 3). Conversion of serine to glycine by tetrahydrofolic acid and forms methylene-tetrahydrofolic acid. 4).to introduce carbon units at position 2 and 8 during de novo purine synthesis requires formyl-tetrahydrofolic acid and methenyl-tetrahydrofolic acid.5).generation and utilization of "formate pool". 6).For mediating formino group transfer in histidine metabolism. Folic acid is required to maintain normal erythropoiesis and nucleoprotein synthesis.Pharmacokinets of Folic AcidAbsorption: Well absorbed orally
Distribution: Widely distributed in the body and highest concentration is seen in liver. It appears in the CSF and breast milk
Metabolism: Metabolized in to N-methyl tetrahydrofolic acid in liver
Excretion: Extra drug is excreted unchanged in urine. A small portion of folate is lost by a combination of urinary and fecal excretion and oxidative cleavage of molecule.
Onset of Action for Folic AcidOral: 20 to 30minutes
I.V.: 5 minutes
I.M.:10 to 20minutes
Duration of Action for Folic AcidOral: 3 to 6 hours
I.V.:3 to 6minutes
I.M.:3 to 6hours
Half Life of Folic AcidN/ASide Effects of Folic AcidN/AContra-indications of Folic AcidN/ASpecial Precautions while taking Folic Acid1. In patients with undiagnosed anaemia; because it may mask pernicious anaemia
2. In pernicious anaemia and other megaloblastic where vitamin B12 is deficient
Pregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationMay be usedIndications for Folic Acid1. Megaloblastic anaemia
2. Folic acid deficiency
3. Anaemias of pregnancy
4. Nutritional anaemia
5. Alcoholism
6. Tropical sprue
7. Non tropical sprue
Interactions for Folic Acid1. Hypersensitivity reactions with injection form
2. Bronchospasm
Typical Dosage for Folic AcidOral: 5mg 1 to 4 times daily; depending up on the severity of deficiency.
Maintenance dosage: Half of the therapeutic dosage.
Children: 2.5 to 5mg 1 to 2 times daily.
Schedule of Folic AcidC1 (Oral)
C (Parenteral)
Storage Requirements for Folic AcidStore at controlled room temperature at a range of 15 to 25 degree C in a well closed container. Protect from excess heat, light and moisture.Effects of Missed Dosage of Folic AcidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Folic AcidRelatively non toxic. Provide symptomatic treatment and supportive measures.Home Delivery for Mecobalamin + L-Carnitine + Folic Acid in Your City
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