Piperacillin Pharmacology

Piperacillin

About Piperacillin
A semisynthetic extended spectrum penicillin(ureidopenicillin), Antiboitic.
Mechanism of Action of Piperacillin
Piperacillin is a semi synthetic antipseudomonal Penicillin. It binds to the Penicillin binding protein in the cell wall of bacteria and inhibits the enzyme transpeptidase which is responsible for the transpeptidation reaction in peptidoglycan synthesis. It also activates the endogenous enzyme which degrades the peptidoglycan.These results in inhibition of protein synthesis and there by cell wall synthesis.Piperacillin is active against both gram positive and gram negative organism.
Pharmacokinets of Piperacillin
Absorption .It is readily absorbed after parenteral administration.
Distribution: It is very widely distributed in the body.
Metabolism: It does not undergo metabolism.
Excretion: It is excreted mainly through urine and small amount excreted through bile and breast milk.
Onset of Action for Piperacillin
Immediate
Duration of Action for Piperacillin
1-2 hours
Half Life of Piperacillin
30 minutes
Side Effects of Piperacillin
1. Nausea
2. Vomiting
3. Diarrhoea
4. Anaphylaxis
5. Rash
6. Urticaria
7. Thrombocytopenia
8. Nephritis
9. Seizure
10. Thrombophlebitis
11. Hypokalemia
Contra-indications of Piperacillin
1. Hypersensitive to Piperacillin and other Penicillins.
Special Precautions while taking Piperacillin
1. Heart failure
2. Uremia
3. Hypokalemia
4. Bleeding tendencies
5. Meningitis
6. Renal impairment
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Piperacillin
1. Urinary tract infections
2. Lower Respiratory tract infections
3. Systemic infections
4. Gynaecological infections
5. Septicaemia
6. Intra-Abdominal Infections
7. Skin and Skin Structure Infections
8. Bone and Joint Infections
Interactions for Piperacillin
Vecuronium: Muscle relaxant action prolonged.
Aminoglycosides: Efficacy of aminoglycosides decreased.
Typical Dosage for Piperacillin
Adult :
Bacterial infections: (IM/IV):200 - 300 mg/kg/day in four divided dose depending on severity of infection
Prophylaxis of surgical infections: 2 g before surgery and 4 g in 2 divided dose after surgery.
Children :
Bacterial infections: 100 - 300 mg/kg/day in 3 - 4 divided dose depending on the severity of infection
Schedule of Piperacillin
H
Storage Requirements for Piperacillin
The vial should be stored in room temperature away from heat and moisture. Keep out of the reach of children
Effects of Missed Dosage of Piperacillin
Take the dose as soon as noticed and if it is the time to the next dose then skip the missed dose.
Effects of Overdose of Piperacillin
Give supportive measures and symptomatic treatment. Haemodialysis can be done , if needed.

Home Delivery for Piperacillin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including piperacillin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for piperacillin and other medicines and health products. Home delivery services for piperacillin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take piperacillin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for piperacillin before they complete the sale. You can get this information while placing the order for piperacillin with the pharmacy.

Piperacillin is a generic medicine name and there are several brands available for it. Some of the brands for piperacillin might be better known than piperacillin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have piperacillin in stock, you can ask for one of the branded alternatives for piperacillin.