Benzyl Nicotinate + Vitamin K + Salicylic Acid Pharmacology

Benzyl Nicotinate + Vitamin K + Salicylic Acid

About Benzyl Nicotinate + Vitamin K + Salicylic Acid
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Mechanism of Action of Benzyl Nicotinate + Vitamin K + Salicylic Acid
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Pharmacokinets of Benzyl Nicotinate + Vitamin K + Salicylic Acid
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Onset of Action for Benzyl Nicotinate + Vitamin K + Salicylic Acid
N/A
Duration of Action for Benzyl Nicotinate + Vitamin K + Salicylic Acid
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Half Life of Benzyl Nicotinate + Vitamin K + Salicylic Acid
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Side Effects of Benzyl Nicotinate + Vitamin K + Salicylic Acid
Local skin manifestations such as rash, pruritus & erythma
Contra-indications of Benzyl Nicotinate + Vitamin K + Salicylic Acid
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Special Precautions while taking Benzyl Nicotinate + Vitamin K + Salicylic Acid
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Pregnancy Related Information
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Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Benzyl Nicotinate + Vitamin K + Salicylic Acid
1.Alopecia Areata
2.Pityrodes (Seborrheic) Senilis & Prematura
3.Symptomatic hair loss after infectious diseases
4.Trichophytia
5.Hair damage caused by chemicals
6.Psoriasis
Interactions for Benzyl Nicotinate + Vitamin K + Salicylic Acid
N/A
Typical Dosage for Benzyl Nicotinate + Vitamin K + Salicylic Acid
Once daily, initially, latter thrice a week
Schedule of Benzyl Nicotinate + Vitamin K + Salicylic Acid
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Storage Requirements for Benzyl Nicotinate + Vitamin K + Salicylic Acid
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Effects of Missed Dosage of Benzyl Nicotinate + Vitamin K + Salicylic Acid
N/A
Effects of Overdose of Benzyl Nicotinate + Vitamin K + Salicylic Acid
N/A

Benzyl nicotinate

About Benzyl nicotinate
Vitamin Nicotinic Acid Benzyl ester, Rubefacient , vasodilator (topical) and miscellaneous antihyperlipidemic agents(systemic).
Mechanism of Action of Benzyl nicotinate
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Pharmacokinets of Benzyl nicotinate
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Onset of Action for Benzyl nicotinate
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Duration of Action for Benzyl nicotinate
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Half Life of Benzyl nicotinate
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Side Effects of Benzyl nicotinate
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Contra-indications of Benzyl nicotinate
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Special Precautions while taking Benzyl nicotinate
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Pregnancy Related Information
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Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Benzyl nicotinate
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Interactions for Benzyl nicotinate
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Typical Dosage for Benzyl nicotinate
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Schedule of Benzyl nicotinate
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Storage Requirements for Benzyl nicotinate
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Effects of Missed Dosage of Benzyl nicotinate
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Effects of Overdose of Benzyl nicotinate
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Vitamin K

About Vitamin K
Fat soluble vitamin, Antihemorrhagic.
Mechanism of Action of Vitamin K
Phytonadione (Vitamin K1) is a synthetic form of vitamin K and is lipid soluble. Vitamin K acts as a cofactor in the synthesis of coagulation proteins; prothrombin, factors VII, IX, and X by liver. Vitamin K dependent changes in the final stage of synthesis of these coagulation proteins is gama-carboxylation of glutamate residues of these zymogen proteins and their descarboxy-forms converted in to active forms; which confers on them the capacity to bind Ca2+ and to get bound to the phospholipid surfaces which are essential properties for participation in the coagulation cascade.
Pharmacokinets of Vitamin K
Absorption: Absorbed orally with the help of bile salts and also administered parenterally.
Distribution: Concentrates in liver in a very short time.
Metabolism: Rapidly metabolized by liver.
Excretion: Excreted through faeces.
Onset of Action for Vitamin K
Oral: 3 to 12hours
I.V., I.M., S.C.: 1 to 2 hours
Duration of Action for Vitamin K
N/A
Half Life of Vitamin K
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Side Effects of Vitamin K
1. Nausea
2. Vomiting
3. Headache
4. Dizziness
5. Convulsive movements
6. Hypotension
7. Arrhythmias
8. Rapid and weak pulse
9. Diaphoresis
10. Flushing
11. Erythema
12. Urticaria
13. Pruritus
14. Rash
15. Bronchospasm
16. Dyspnea
17. Anaphylactic reactions
18. Kernicterus

Contra-indications of Vitamin K
1. Hypersensitivity to the drug
Special Precautions while taking Vitamin K
N/A
Pregnancy Related Information
Contraindicated
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Vitamin K
1. Hypoprothrombinemia due to Vitamin K malabsorption or drug therapy or inadequate bile secretion
2. Hypoprothrombinemia due to Vitamin K malabsorption or drug therapy or excess vitamin A
3. Hypoprothrombinemia due to oral anticoagulants
4. Hypoprothrombinemia due to vitamin K deficiency due to long term parenteral nutrition
5. Hemorrhagic disease in neonates
6. Uterine bleeding
7. Metrorrhagia
8. Post partum bleeding
9. Haemoptysis
10. Epistaxis
11. Haematemesis
12. Obstructive jaundice
Interactions for Vitamin K
Anticoagulants: It may be necessary to increase the anticoagulant dose.
Mineral oil: May decrease Gl absorption of vitamin K.
Typical Dosage for Vitamin K
Hypoprothrombinemia due to Vitamin K malabsorption or drug therapy or inadequate bile secretion: 5 to 10mg/day orally. Adjust the dosage based on patient`s response.
Hypoprothrombinemia due to Vitamin K malabsorption or drug therapy or excess vitamin A: 2 to 25mg orally or parenterally. Increases the dosage up to 50mg if required.
Children: 5 to 10mg
Infants: 2mg
Hypoprothrombinemia due to oral anticoagulants:2.5 to 10mg orally, subcutaneously or intramuscularly. Repeated if required.
For emergency management: 10 to 50mg as slow I.V; rate not more than 1mg/minute. Repeated four times daily or three times daily if required.
Hypoprothrombinemia due to vitamin K deficiency due to long term parenteral nutrition: 5 to 10mg; intramuscularly weekly.
Children: 2 to 5mg
Hemorrhagic disease in neonates: 500mcg to 1000mcg S.C. or I.M. immediately after birth. Repeated in two to three weeks if needed.

Schedule of Vitamin K
N/A
Storage Requirements for Vitamin K
Store at room temperature away from excess heat and moisture. Protect from light.
Effects of Missed Dosage of Vitamin K
N/A
Effects of Overdose of Vitamin K
Treatment is supportive and symptomatic

Salicylic Acid

About Salicylic Acid
A beta hydroxy acid, Keratolytic, Topical Skin Product(Anti Acne).
Mechanism of Action of Salicylic Acid
It is a keratolytic agent. It encourages exfoliation of the skin and opening up of the plugged follicles, which helps re-establish the normal skin- cell replacement cycle. For milder acne, salicylic acid helps unclog pores to resolve and prevent lesions.
Pharmacokinets of Salicylic Acid
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Onset of Action for Salicylic Acid
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Duration of Action for Salicylic Acid
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Half Life of Salicylic Acid
N/A
Side Effects of Salicylic Acid
1.Allergic reaction
2.Hives
3.Difficulty breathing
4.Swelling of your face, lips, tongue, or throat.
Contra-indications of Salicylic Acid
1.Hypersensitivity to Salicylic acid
Special Precautions while taking Salicylic Acid
1.Avoid contact with eyes, mouth, or nose.
2.Like many other topical acne treatments, salicylic acid must be used continuously, even after acne lesions have.
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Salicylic Acid
1.Treats skin irritation and inflammation caused by burns, insect bites, fungal infections, and eczema.
Interactions for Salicylic Acid
N/A
Typical Dosage for Salicylic Acid
Use this medication twice daily
Schedule of Salicylic Acid
N/A
Storage Requirements for Salicylic Acid
Store in a cool dry place. Protect from heat and light. Keep out of the reach of children
Effects of Missed Dosage of Salicylic Acid
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Salicylic Acid
Give supportive measures and symptomatic treatment.

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