Doxofylline + Montelukast Pharmacology

Doxofylline + Montelukast

About Doxofylline + Montelukast
N/A
Mechanism of Action of Doxofylline + Montelukast
N/A
Pharmacokinets of Doxofylline + Montelukast
N/A
Onset of Action for Doxofylline + Montelukast
N/A
Duration of Action for Doxofylline + Montelukast
N/A
Half Life of Doxofylline + Montelukast
N/A
Side Effects of Doxofylline + Montelukast
N/A
Contra-indications of Doxofylline + Montelukast
N/A
Special Precautions while taking Doxofylline + Montelukast
N/A
Pregnancy Related Information
Use with caution
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
<6 mth, Use with caution
Indications for Doxofylline + Montelukast
Asthma
Interactions for Doxofylline + Montelukast
N/A
Typical Dosage for Doxofylline + Montelukast
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Schedule of Doxofylline + Montelukast
N/A
Storage Requirements for Doxofylline + Montelukast
N/A
Effects of Missed Dosage of Doxofylline + Montelukast
N/A
Effects of Overdose of Doxofylline + Montelukast
N/A

Doxofylline

About Doxofylline
A xanthine derivative, Phosphodiesterase inhibitor, Antiasthmatic,antitussive and bronchodilator.
Mechanism of Action of Doxofylline
Similar efficacy to theophylline but with significantly less side effects.
Its mechanism of action is related to the inhibition of phosphodiesterase activities, resulting in bronchodilating effects. Unlike other xanthines, doxofylline lacks any significant affinity for adenosine receptors and does not produce stimulant effects.
Pharmacokinets of Doxofylline
N/A
Onset of Action for Doxofylline
N/A
Duration of Action for Doxofylline
N/A
Half Life of Doxofylline
N/A
Side Effects of Doxofylline
1.Nausea
2.Vomiting
3.Tremor
4.Palpitation.
Contra-indications of Doxofylline
1.Hypersensitivity
2.Myocardial infaraction
3.Doxofilline and other methyxanthine derivatives.
4.Methyxanthines are not recommended for therapy of asthma exacerbations
Special Precautions while taking Doxofylline
Should be used cautiously in patients with active ulcer disease, asthma, bts bleeding disorders, mild renal impairment. Renal toxicity may occurs, caution should be exercised when know renal dysfunction or H/o of renal disease.
Pregnancy Related Information
Use with Caution
Old Age Related Information
N/A
Breast Feeding Related Information
Use with Caution
Children Related Information
N/A
Indications for Doxofylline
Bronchial Asthma and COPD.
Interactions for Doxofylline
Cocomitant administration with other xanthines derivatives, Phenytoin.
Typical Dosage for Doxofylline
Adult:400mg once a day. Single dose, administration in the evening reduces nocturnal, symptoms and helps to keep the patients complaint free during the day.
400mg twice daily is recommended on the basis of the clinical response.

Schedule of Doxofylline
N/A
Storage Requirements for Doxofylline
N/A
Effects of Missed Dosage of Doxofylline
N/A
Effects of Overdose of Doxofylline
N/A

Montelukast

About Montelukast
Leukotriene(CysLT1) Receptor Antagonist, Antiinflammatory,antiasthma.
Mechanism of Action of Montelukast
Montelukast is competitively and selectively antagonizes CysLT1 receptor (leukotrienes receptor) mediated Bronchoconstriction.Montelukast inhibits physiologic actions of LTD 4 at the CysLT1 receptor without any agonist activity.
Pharmacokinets of Montelukast
Absorption: Montelukast is rapidly absorbed after oral administration and its bioavailability is about 60 - 70%.
Distribution: It is minimally distributed to the tissues in protein bound form (99%)
Metabolism: It is extensively metabolised in the liver.
Excretion: Montelukast is excreted in the faeces.

Onset of Action for Montelukast
N/A
Duration of Action for Montelukast
N/A
Half Life of Montelukast
2.75 - 5.5 hours
Side Effects of Montelukast
1.Headache
2.Dizziness
3.Nasal congestion
4.Sore throat
5.Abdominal pain
6.Fatigue
7.Asthenia
8.Cough
9.Influenza
10.Rash
11.Fever
12.Trauma
13.Trauma
14.Dyspepsia
Contra-indications of Montelukast
1.Hypersensitivity to Montelukast
2.Acute asthmatic attacks
Special Precautions while taking Montelukast
N/A
Pregnancy Related Information
Use with caution.
Old Age Related Information
May be used.
Breast Feeding Related Information
Use with caution.
Children Related Information
May be used
CHILDREN below 6 years : contraindicated
NEONATES: contraindicated
Indications for Montelukast
Asthma.
Interactions for Montelukast
Barbiturates & Primidone: Plasma concentration of montelukast is reduced by phenobarbital.
Typical Dosage for Montelukast
Adult: 10 mg / day at bed time
Children (6 - 14 years): 5mg/day at bed time

Schedule of Montelukast
N/A
Storage Requirements for Montelukast
Store at room temperature. Protect from heat and light. Keep out of the reach of children.
Effects of Missed Dosage of Montelukast
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Montelukast
Give supportive measures and symptomatic treatment

Home Delivery for Doxofylline + Montelukast in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for doxofylline + montelukast and other medicines and health products. Home delivery services for doxofylline + montelukast may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take doxofylline + montelukast only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for doxofylline + montelukast before they complete the sale. You can get this information while placing the order for doxofylline + montelukast with the pharmacy.

Doxofylline + Montelukast is a generic medicine name and there are several brands available for it. Some of the brands for doxofylline + montelukast might be better known than doxofylline + montelukast itself. If the pharmacy that's willing to deliver medicines to your home doesn't have doxofylline + montelukast in stock, you can ask for one of the branded alternatives for doxofylline + montelukast.