Lornoxicam Pharmacology

Lornoxicam

About Lornoxicam
Non-steroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic (pain relieving), anti-inflammatory and antipyretic (fever reducing) properties. It is available in oral and parenteral formulations.
Mechanism of Action of Lornoxicam
Like other NSAIDs, lornoxicam inhibits prostaglandin biosynthesis by blocking the enzyme cyclooxygenase. Lornoxicam inhibits both isoforms in the same concentration range, that is, the ratio of COX-1 inhibition to COX-2 inhibition is 1:1. It readily penetrates into the synovial fluid.
Pharmacokinets of Lornoxicam
Absorption:well absorbed oraly,food delays absorption

Distribution: 99% bound to plasma proteins.

Metabolism: Metabolised to its inactive metabolite

Elimination:Approximately 1/2 to 2/3 is eliminated via the liver and 1/3 to 42% via the
kidneys as 5?-hydroxylornoxicam.
Onset of Action for Lornoxicam
N/A
Duration of Action for Lornoxicam
N/A
Half Life of Lornoxicam
3-4 hr.
Side Effects of Lornoxicam
1.Gastrointestinal disorders (nausea and diarrhea)
2.Headache.
3.Severe but seldom side effects include bleeding, bronchospasms and the extremely rare stevens?johnson syndrome
Contra-indications of Lornoxicam
1.Salicylate sensitivity
2.Gastrointestinal bleeding and bleeding disorders
3.Severe impairment of heart, liver or kidney function
Special Precautions while taking Lornoxicam
1.Active infections
2.Asthma
3.Allergic disorders
4.Haemorrhagic disorders
5.Hypertension
6.Impaired renal, hepatic, cardiac function.
7.Lornoxicam should be taken with a meal to minimise gastrointestinal irritation.
Pregnancy Related Information
Cotra indicated
Old Age Related Information
Reduce the dose
Breast Feeding Related Information
Cotra indicated
Children Related Information
Do not use lornoxicam in children under the age of 18
Indications for Lornoxicam
Treatment of various types of pain, especially resulting from inflammatory diseases of the joints, osteoarthritis, surgery, sciatica, and other inflammations.
Interactions for Lornoxicam
1.Vitamin K antagonists like warfarin increases the risk of bleeding.
2.Ciclosporin can lead to reduced kidney function, and to acute renal failure in rare cases.
3.Lornoxicam can also increase the adverse effects of lithium, methotrexate and digoxin and its derivatives.
4.The effect of diuretics, ACE inhibitors and angiotensin II receptor antagonists can be reduced, but this is only relevant in patients with special risks like heart failure.
5.Piroxicam, cimetidine can increase plasma levels
Typical Dosage for Lornoxicam
1.Pain relief:Adult: 8-16 mg daily. Max: 24 mg daily. (Oral)
2.Osteoarthritis:Adult: 12 mg daily in 2-3 divided doses, up to 16 mg daily if needed.(Oral)
3.Rheumatoid arthritis:Adult: 12 mg daily in 2-3 divided doses, up to 16 mg daily if needed.Parenteral
4.Pain relief:Adult: 8 mg once or twice daily by IM/IV inj. Max: 24 mg daily.
Schedule of Lornoxicam
Schedule H
Storage Requirements for Lornoxicam
N/A
Effects of Missed Dosage of Lornoxicam
N/A
Effects of Overdose of Lornoxicam
A small overdose is no cause for concern. In case of intentional large overdose, seek emergency medical attention.

Home Delivery for Lornoxicam in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including lornoxicam.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for lornoxicam and other medicines and health products. Home delivery services for lornoxicam may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take lornoxicam only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for lornoxicam before they complete the sale. You can get this information while placing the order for lornoxicam with the pharmacy.

Lornoxicam is a generic medicine name and there are several brands available for it. Some of the brands for lornoxicam might be better known than lornoxicam itself. If the pharmacy that's willing to deliver medicines to your home doesn't have lornoxicam in stock, you can ask for one of the branded alternatives for lornoxicam.