Latanoprost + Benzalkonium Chloride Pharmacology

Latanoprost + Benzalkonium Chloride

About Latanoprost + Benzalkonium Chloride
Prostaglantin analogues
Mechanism of Action of Latanoprost + Benzalkonium Chloride
Latanoprost is a prostaglandin F2a analogue. Specifically, Latanoprost is a prostanoid selective FP receptor agonist that is believed to reduce the intraocular pressure (IOP) by increasing the outflow of aqueous humor. Studies in animals and man suggest that the main mechanism of action is increased uveoscleral outflow. Elevated IOP represents a major risk factor for glaucomatous field loss. The higher the level of IOP, the greater the likelihood of optic nerve damage and visual field loss.
Pharmacokinets of Latanoprost + Benzalkonium Chloride
Absorption :Latanoprost is well absorbed through the cornea where the isopropyl ester prodrug is hydrolyzed to the acid form. Peak concentration is reached 2 hrs after topical administration.

Metabolism
Primarily hepatic (none except hydrolysis in the eye). Latanoprost is an isopropyl ester prodrug. It is hydrolyzed by esterases in the cornea to latanoprost acid, which is biologically active. The portion of the latanoprost acid that reaches the systemic circulation is metabolized primarily by the liver to 1,2-dinor and 1,2,3,4-tetranor metabolites by fatty acid beta-oxidation.
Onset of Action for Latanoprost + Benzalkonium Chloride
N/A
Duration of Action for Latanoprost + Benzalkonium Chloride
N/A
Half Life of Latanoprost + Benzalkonium Chloride
17 minutes
Side Effects of Latanoprost + Benzalkonium Chloride
1.Eyelash changes (increased length, thickness, pigmentation, and number of
lashes);
2.Eyelid skin darkening
3.Intraocular inflammation (iritis/uveitis)
4.Iris
5.Pigmentation changes;
6.Macular edem
7.Cystoid macular edema
Contra-indications of Latanoprost + Benzalkonium Chloride
Hypersensitivity
Special Precautions while taking Latanoprost + Benzalkonium Chloride
N/A
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Latanoprost + Benzalkonium Chloride
Latanoprost:for the reduction of elevated intraocular pressure in patients with open angle glaucoma and ocular hypertension.



Interactions for Latanoprost + Benzalkonium Chloride
N/A
Typical Dosage for Latanoprost + Benzalkonium Chloride
N/A
Schedule of Latanoprost + Benzalkonium Chloride
N/A
Storage Requirements for Latanoprost + Benzalkonium Chloride
Store at temperature between 20 to 80 C. Protect from light., Once opened the vial
may be stored at room temperature.
Effects of Missed Dosage of Latanoprost + Benzalkonium Chloride
N/A
Effects of Overdose of Latanoprost + Benzalkonium Chloride
N/A

Latanoprost

About Latanoprost
A prostaglandin analogue, Antiglaucoma.
Mechanism of Action of Latanoprost
Latanoprost is a prostaglandin F2-alpha analogue and it is a prostanoid selective FP receptor agonist which reduces the intraocular pressure (IOP) by increasing the outflow of aqueous humor mainly through increasing uveoscleral outflow.
Chemically Latanoprost is an isopropyl ester prodrug and after hydrolyses it forms active acid form.
Pharmacokinets of Latanoprost
Absorption: Latanoprost is absorbed through cornea after ocular administration
Onset of Action for Latanoprost
2 - 4 hour
Duration of Action for Latanoprost
N/A
Half Life of Latanoprost
N/A
Side Effects of Latanoprost
1.Irritation
2.Burning
3.Blurred vision
4.Increased sensitivity of the eyes to light
5.Dry eyes
6.Increased flow of tears
7.Changes in eye, eyelash, or eyelid color
8.Redness of eyes
9.Asthma
10.Eye pain
11.Punctate epithelial keratopathy
Contra-indications of Latanoprost
1.Hypersensitivity to Latanoprost
Special Precautions while taking Latanoprost
1.Avoid use of medicament if any irritation occurs
2.Iritis
3.Uveitis
4.Macular edema
5.Aphakia
6.Closed angle glaucoma
7.Avoid contact lens
8.Renal impairment
9.Hepatic impairment
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Contraindicated

Indications for Latanoprost
1.Open angle glaucoma
Interactions for Latanoprost
N/A
Typical Dosage for Latanoprost
Latanoprost 0.005 % eye drop is used.
Instill 1 drop in the evening to the affected eye.
Schedule of Latanoprost
N/A
Storage Requirements for Latanoprost
Store in a cool dry place in a tightly closed container. Protect fro heat and light. Keep out of the reach of children. Discard the drug 1 month after opening.
Effects of Missed Dosage of Latanoprost
Instill the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Latanoprost
A topical ocular overdose of an ophthalmic product containing Latanoprost may be flushed from the eye with warm tap water.

Benzalkonium Chloride

About Benzalkonium Chloride
A nitrogenous cationic surfactant, Quaternary ammonium compound, Antiseptic,Disinfectant, A vaginal contraceptive spermicidal agent.
Mechanism of Action of Benzalkonium Chloride
The mechanism of bactericidal/microbicidal action is due to disruption of intermolecular interactions. This cause dissociation of cellular membrane bilayers, which compromises cellular permeability controls and induces leakage of cellular contents. Other biomolecular complexes within the bacterial cell can also undergo dissociation. It also inactivates the enzyme produced by different microorganisms. It also has spermicidal action. They work by damaging and killing sperm in the vagina. Therefore, the sperm are not able to travel from the vagina into the uterus and fallopian tubes, where fertilization usually takes place.
Pharmacokinets of Benzalkonium Chloride
N/A
Onset of Action for Benzalkonium Chloride
N/A
Duration of Action for Benzalkonium Chloride
N/A
Half Life of Benzalkonium Chloride
N/A
Side Effects of Benzalkonium Chloride
1. Chills
2. Confusion
3. Dizziness
4. Fever
5. Lightheadedness
6. Muscle aches
7. Sunburn-like skin rash
8. Cloudy or bloody urine
9. Increased frequency of urination
10. Pain in the bladder or lower abdomen
11. Pain on urination; thick
12. White or curd-like vaginal discharge-with use of cervical caps or diaphragms
13. Vaginal dryness
14. Odor
Contra-indications of Benzalkonium Chloride
1. Hypersensitivity to the drug
2. Allergies, irritations, or infections of the genitals
3. Recent abortion
4. Sores on the genitals (sex organs)
5. Irritation of the vagina
Special Precautions while taking Benzalkonium Chloride
Discontinue use if you have abnormal discharge or vaginal burning or itching.
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Benzalkonium Chloride
1. Antisepsis of skin, mucous membranes, and wounds.
2. Preoperative preparation of the skin, surgeons` hand and arm soaks
3. Treatment of wounds
4. Preservation of ophthalmic solutions
5. Irrigations of the eye, body cavities, bladder, urethra
6. Vaginal douching.
7. Contraceptives
Interactions for Benzalkonium Chloride
N/A
Typical Dosage for Benzalkonium Chloride
Vaginal suppositories dosage form (preventing pregnancy):
Adults and teenagers-
For use alone: One suppository inserted into the vagina at least ten minutes but not longer than four hours before each time you have sexual intercourse.
With a diaphragm: After the diaphragm with spermicide has been placed into the vagina, insert one suppository at least ten minutes, but not longer than four hours, before each time you have sexual intercourse. Also, insert another suppository before sexual intercourse if six hours have passed since you inserted the diaphragm
Schedule of Benzalkonium Chloride
N/A
Storage Requirements for Benzalkonium Chloride
Store at controlled room temperature, away from light and excessive heat. Keep out of reach of children.
Effects of Missed Dosage of Benzalkonium Chloride
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Benzalkonium Chloride
N/A

Home Delivery for Latanoprost + Benzalkonium Chloride in Your City

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Latanoprost + Benzalkonium Chloride is a generic medicine name and there are several brands available for it. Some of the brands for latanoprost + benzalkonium chloride might be better known than latanoprost + benzalkonium chloride itself. If the pharmacy that's willing to deliver medicines to your home doesn't have latanoprost + benzalkonium chloride in stock, you can ask for one of the branded alternatives for latanoprost + benzalkonium chloride.