Urea + Calcipotriol Pharmacology

Urea + Calcipotriol

About Urea + Calcipotriol
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Mechanism of Action of Urea + Calcipotriol
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Pharmacokinets of Urea + Calcipotriol
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Onset of Action for Urea + Calcipotriol
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Duration of Action for Urea + Calcipotriol
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Half Life of Urea + Calcipotriol
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Side Effects of Urea + Calcipotriol
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Contra-indications of Urea + Calcipotriol
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Special Precautions while taking Urea + Calcipotriol
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Urea + Calcipotriol
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Interactions for Urea + Calcipotriol
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Typical Dosage for Urea + Calcipotriol
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Schedule of Urea + Calcipotriol
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Storage Requirements for Urea + Calcipotriol
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Effects of Missed Dosage of Urea + Calcipotriol
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Effects of Overdose of Urea + Calcipotriol
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Urea

About Urea
Diamide salt of carbonic acid, Topical dermatological product ,Moisturiser.
Mechanism of Action of Urea
Urea is used in skin preparations as hydrating agent.It is used in scaling conditions and may be ueful in elderly patients.It is occassionally used with corticosteroids to enhance penetration of corticosteroids.
Pharmacokinets of Urea
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Onset of Action for Urea
N/A
Duration of Action for Urea
N/A
Half Life of Urea
N/A
Side Effects of Urea
1.Skin rash
2.Stinging
3.Irritation
Contra-indications of Urea
1.Hypersensitivity to the drug
Special Precautions while taking Urea
Broken, inflamed, or burnt skin
Infection
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Urea
1.As moisturiser
Interactions for Urea
N/A
Typical Dosage for Urea
Apply a thin film to the affected area.
Schedule of Urea
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Storage Requirements for Urea
Store at room temperature between 15 and 30 degrees C .Keep in a well closed container. Keep out of the reach of children.
Effects of Missed Dosage of Urea
Apply the missed dose as soon as noticed. If it is almost time for the next dose, skip the missed dose and continue the regular schedule.
Effects of Overdose of Urea
Give supportive measures and symptomatic treatment.

Calcipotriol

About Calcipotriol
It is a new vitamin D analogue. Non-steroidal Antipsoriatic.
Mechanism of Action of Calcipotriol
Calcipotriol is a vitamin D analogue. It is a non-steroidal anti-psoriatic agent. Since it is a vitamin-D analogue it competes for 1, 25 (OH)2 D3 receptor. Calcipotriol is as potent as 1, 25 Dihydroxy cholecalciferol and regulating cell proliferation and cell differentiation, but much less active than Dihydroxy cholecalciferol in its effect on calcium metabolism. Calcipotriol induces keratinocytes differentiation and suppresses proliferation. Thus it reverses the abnormal keratinocytes changes in psoriasis and also normalizes epidermal growth. . When applied to the skin it works by reducing the production of skin cells. In psoriasis, the scaling and thickening of the skin and the appearance of raised plaques, are the result of excessive skin cell production. Calcipotriol reduces the excessive skin cell production and therefore helps improve the symptoms of psoriasis.
Calcipotriol is used to treat plaque psoriasis: Plaque psoriasis is a skin disorder caused by rapid multiplication of cells in the outer layer of the skin. As new skin cells are produced, old ones are shed. If this process is taking place too quickly, old skin cells build up on the skin surface causing red, scaly patches. Calcipotriol helps to control psoriasis by slowing down the production of new skin cells.
Pharmacokinets of Calcipotriol
Absorption: About 5 - 6 % drug is absorbed after topical application.
Onset of Action for Calcipotriol
N/A
Duration of Action for Calcipotriol
N/A
Half Life of Calcipotriol
N/A
Side Effects of Calcipotriol
1.Local irritation
2.Photosnsitivity
3.Burning
4.Pruritis
5.Atrophy
6.Dermatitis
7.Dryness of the skin
8.Hyperpigmentation
9.Folliculitis
10.Erythema
11.Peeling
12. Rashes
Contra-indications of Calcipotriol
1. Hypersensitivity to Calcipotriol
2.Hypercalcaemia
3.Hypercalciuria
4.Hypervitaminosis D
5.Nephrolithiasis
6.Severe extensive psoriasis

Special Precautions while taking Calcipotriol
1.If irritation occurs discontinue the use of medicaments
2.Avoid use on face and eyes
3.Avoid exposure to sunlight
4.For external use only
5.Excessive prolonged use
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Use with caution.
Children Related Information
Contraindicated
Indications for Calcipotriol
Chronic stable plaque type psoriasis in adults.
Interactions for Calcipotriol
N/A
Typical Dosage for Calcipotriol
Topical: 0.005%w/w Calcipotriol is used.
Apply as thin layer to the affected area with gentle massage 2 times daily
Wash hands before and after application
Schedule of Calcipotriol
H
Storage Requirements for Calcipotriol
Store in a cool dry place away from heat and direct sunlight. Keep out of the reach of children
Effects of Missed Dosage of Calcipotriol
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Calcipotriol
Give supportive measures and symptomatic treatment

Home Delivery for Urea + Calcipotriol in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including urea + calcipotriol.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for urea + calcipotriol and other medicines and health products. Home delivery services for urea + calcipotriol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take urea + calcipotriol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for urea + calcipotriol before they complete the sale. You can get this information while placing the order for urea + calcipotriol with the pharmacy.

Urea + Calcipotriol is a generic medicine name and there are several brands available for it. Some of the brands for urea + calcipotriol might be better known than urea + calcipotriol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have urea + calcipotriol in stock, you can ask for one of the branded alternatives for urea + calcipotriol.